E75BB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E75BB_DROME
• UniProt AC: P13055
• Protein Name: Ecdysone-induced protein 75B, isoform B
• Gene Name: Eip75B
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1412
• Subcellular Localization: Nucleus .
• Protein Description: Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone..
• Protein Sequence: MEAVQAAAAATSSGGSSGSVPGSGSGSASKLIKTEPIDFEMLHLEENERQQDIEREPSSSNSNSNSNSLTPQRYTHVQVQTVPPRQPTGLTTPGGTQKVILTPRVEYVQQRATSSTGGGMKHVYSQQQGTAASRSAPPETTALLTTTSGTPQIIITRTLPSNQHLSRRHSASPSALHHYQQQQPQRQQSPPPLHHQQQQQQQHVRVIRDGRLYDEATVVVAARRHSVSPPPLHHHSRSAPVSPVIARRGGAAAYMDQQYQQRQTPPLAPPPPPPPPPPPPPPPQQQQQQYISTGVPPPTAAARKFVVSTSTRHVNVIASNHFQQQQQQHQAQQHQQQHQQHQQHQQHVIASVSSSSSSSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGNSVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLEFDGTTVLCRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDCPSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLTQDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANARFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQYIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTESADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLSGGCPLRNRANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGHAMCQQQQQHPQLHHHLTAGAARYRKLDSPTDSGIESGNEKNECKAVSSGGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVSPVRSPQPSTSSHLKRQIVEDMPVLKRVLQAPPLYDTNSLMDEAYKPHKKFRALRHREFETAEADASSSTSGSNSLSAGSPRQSPVPNSVATPPPSAASAAAGNPAQSQLHMHLTRSSPKASMASSHSVLAKSLMAEPRMTPEQMKRSDIIQNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQRWGSSSVITTTCQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQYFQSPHSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSKLHALVAAANAVQRYPTLSADVTVTASNGGPPSAAASPAPSSSPPASVGSPNPGLSAAVHKVMLEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
238	Phosphorylation	PLHHHSRSAPVSPVI CCCCCCCCCCCCCHH	39.68	27626673
242	Phosphorylation	HSRSAPVSPVIARRG CCCCCCCCCHHHHCC	16.64	27626673
986	Phosphorylation	ARYRKLDSPTDSGIE HHHHCCCCCCCCCCC	39.89	19429919
988	Phosphorylation	YRKLDSPTDSGIESG HHCCCCCCCCCCCCC	46.91	19429919
1011	Phosphorylation	VSSGGSSSCSSPRSS ECCCCCCCCCCCCCC	21.51	29892262
1013	Phosphorylation	SGGSSSCSSPRSSVD CCCCCCCCCCCCCHH	45.37	27626673
1014	Phosphorylation	GGSSSCSSPRSSVDD CCCCCCCCCCCCHHH	28.76	21082442
1340	Phosphorylation	PLNLSKKSPTPPPSK CCCCCCCCCCCCHHH	37.43	22817900
1342	Phosphorylation	NLSKKSPTPPPSKLH CCCCCCCCCCHHHHH	56.36	22817900
1346	Phosphorylation	KSPTPPPSKLHALVA CCCCCCHHHHHHHHH	54.33	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E75BB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E75BB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E75BB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHEB_DROME	Rheb	genetic	26771490

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.