RHEB_DROME - dbPTM
RHEB_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHEB_DROME
UniProt AC Q9VND8
Protein Name GTP-binding protein Rheb homolog
Gene Name Rheb
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 182
Subcellular Localization Endomembrane system
Lipid-anchor
Cytoplasmic side . Golgi apparatus membrane
Lipid-anchor
Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane
Lipid-anchor
Cytoplasmic side .
Protein Description Binds GTP and exhibits intrinsic GTPase activity (By similarity). Activates the protein kinase activity of TORC1, and thereby plays a role in the regulation of apoptosis. [PubMed: 22493059 Stimulates the phosphorylation of S6K through activation of TORC1 signaling]
Protein Sequence MPTKERHIAMMGYRSVGKSSLCIQFVEGQFVDSYDPTIENTFTKIERVKSQDYIVKLIDTAGQDEYSIFPVQYSMDYHGYVLVYSITSQKSFEVVKIIYEKLLDVMGKKYVPVVLVGNKIDLHQERTVSTEEGKKLAESWRAAFLETSAKQNESVGDIFHQLLILIENENGNPQEKSGCLVS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
50PhosphorylationTKIERVKSQDYIVKL
EEEEECCCCCEEEEE
25.9819429919
179FarnesylationNPQEKSGCLVS----
CCCCCCCCCCC----
4.35-
179MethylationNPQEKSGCLVS----
CCCCCCCCCCC----
4.35-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHEB_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHEB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHEB_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TFDP_DROMEDpgenetic
15084262
SIN1_DROMESin1genetic
22319582
SESN_DROMESesngenetic
20203043
UNK_DROMEunkgenetic
25210733
TOR_DROMETorgenetic
12766775
TOR_DROMETorgenetic
22319582
RL36_DROMERpL36physical
27626673
LSG1_DROMENs3physical
27626673
ACTN_DROMEActnphysical
27626673
ACT1_DROMEAct5Cphysical
27626673
SQH_DROMEsqhphysical
27626673
RL7A_DROMERpL7Aphysical
27626673
RL17_DROMERpL17physical
27626673
RS6_DROMERpS6physical
27626673
HSP7C_DROMEHsc70-3physical
27626673
NONA_DROMEnonAphysical
27626673
IF2A_DROMEeIF-2alphaphysical
27626673
RS5A_DROMERpS5aphysical
27626673
CAPZB_DROMEcpbphysical
27626673
EIF3I_DROMETrip1physical
27626673
IF4A_DROMEeIF-4aphysical
27626673
Y3096_DROMECG13096physical
27626673
RL13_DROMERpL13physical
27626673
RL9_DROMERpL9physical
27626673
NOC2L_DROMECG9246physical
27626673
TERA_DROMETER94physical
27626673
ISWI_DROMEIswiphysical
27626673
EIF3M_DROMETango7physical
27626673
RS23_DROMERpS23physical
27626673
HSP7E_DROMEHsc70-5physical
27626673
ACT3_DROMEAct57Bphysical
27626673
CAPZA_DROMEcpaphysical
27626673
RTF1_DROMERtf1physical
27626673
FBRL_DROMEFibphysical
27626673
MYSN_DROMEzipphysical
27626673
RL18_DROMERpL18physical
27626673
RL14_DROMERpL14physical
27626673
R10AB_DROMERpL10Abphysical
27626673
EIF3L_DROMECG5642physical
27626673
AGO2_DROMEAGO2physical
27626673
EIF3A_DROMEeIF3-S10physical
27626673
DDX17_DROMERm62physical
27626673
TCTP_DROMETctpphysical
27151460
SQD_DROMEsqdphysical
27626673
IF2G_DROMEeIF-2gammaphysical
27626673
1433E_DROME14-3-3epsilonphysical
27626673
TCPA_DROMET-cp1physical
27626673
RS7_DROMERpS7physical
27626673
ATPB_DROMEATPsyn-betaphysical
27626673
RL10_DROMERpL10physical
27626673
RL8_DROMERpL8physical
27626673
NSUN2_DROMENsun2physical
27626673
ANKHM_DROMEmaskphysical
27626673

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHEB_DROME

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Related Literatures of Post-Translational Modification

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