AGO2_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGO2_DROME
• UniProt AC: Q9VUQ5
• Protein Name: Protein argonaute-2
• Gene Name: AGO2 {ECO:0000312|EMBL:AAF49620.2}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1214
• Protein Description: Essential for RNA interference (RNAi); double-stranded RNA induces potent and specific gene silencing. RNAi is mediated by the RNA-induced silencing complex (RISC), a sequence-specific, multicomponent nuclease that destroys or silences messenger RNAs homologous to the silencing trigger..
• Protein Sequence: MGKKDKNKKGGQDSAAAPQPQQQQKQQQQRQQQPQQLQQPQQLQQPQQLQQPQQQQQQQPHQQQQQSSRQQPSTSSGGSRASGFQQGGQQQKSQDAEGWTAQKKQGKQQVQGWTKQGQQGGHQQGRQGQDGGYQQRPPGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHQQGRQGQEGGYQQRPPGQQQGGHEQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPSGQQQGGHQQGRQGQEGGYQQRPPGQQPNQTQSQGQYQSRGPPQQQQAAPLPLPPQPAGSIKRGTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKASCYSVDKLPLNSQNPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSLTTYMNDRIFDKPMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPNNRHELDDGYEALVGLYQAFMLGDRPFLNVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVYRVNGLSRAPASSETFEHDGKKVTIASYFHSRNYPLKFPQLHCLNVGSSIKSILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPTISRFGIRIANDFIVVSTRVLSPPQVEYHSKRFTMVKNGSWRMDGMKFLEPKPKAHKCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVNISLDSDVTYRPFTDDERSLDTIFADLKRSQHDLAIVIIPQFRISYDTIKQKAELQHGILTQCIKQFTVERKCNNQTIGNILLKINSKLNGINHKIKDDPRLPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQYRLQRGALEEIEDMFSITLEHLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCKPKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTRYNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTGTNRFLDLKKEYAKRTIVPEFMKKNPMYFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	Phosphorylation	SSGGSRASGFQQGGQ CCCCHHHCCCCCCCC	38.74	19429919
93	Phosphorylation	QGGQQQKSQDAEGWT CCCCCCCCCCCCCCH	29.02	19429919
133	Phosphorylation	RQGQDGGYQQRPPGQ CCCCCCCCCCCCCCC	13.65	18281928
156	Phosphorylation	RQGQEGGYQQRPPGQ CCCCCCCCCCCCCCC	16.60	18281928
179	Phosphorylation	RQGQEGGYQQRPSGQ CCCCCCCCCCCCCCC	16.60	18281928
184	Phosphorylation	GGYQQRPSGQQQGGH CCCCCCCCCCCCCCC	51.96	25749252
202	Phosphorylation	RQGQEGGYQQRPPGQ CCCCCCCCCCCCCCC	16.60	18281928
225	Phosphorylation	RQGQEGGYQQRPSGQ CCCCCCCCCCCCCCC	16.60	18281928
230	Phosphorylation	GGYQQRPSGQQQGGH CCCCCCCCCCCCCCC	51.96	25749252
248	Phosphorylation	RQGQEGGYQQRPPGQ CCCCCCCCCCCCCCC	16.60	18281928
271	Phosphorylation	RQGQEGGYQQRPPGQ CCCCCCCCCCCCCCC	16.60	18281928
294	Phosphorylation	RQGQEGGYQQRPSGQ CCCCCCCCCCCCCCC	16.60	18281928
299	Phosphorylation	GGYQQRPSGQQQGGH CCCCCCCCCCCCCCC	51.96	25749252
317	Phosphorylation	RQGQEGGYQQRPSGQ CCCCCCCCCCCCCCC	16.60	18281928
322	Phosphorylation	GGYQQRPSGQQQGGH CCCCCCCCCCCCCCC	51.96	25749252
340	Phosphorylation	RQGQEGGYQQRPSGQ CCCCCCCCCCCCCCC	16.60	18281928
345	Phosphorylation	GGYQQRPSGQQQGGH CCCCCCCCCCCCCCC	51.96	25749252
404	Phosphorylation	LPPQPAGSIKRGTIG CCCCCCCCCCCCCCC	27.35	21082442
409	Phosphorylation	AGSIKRGTIGKPGQV CCCCCCCCCCCCCCE	30.50	18511481

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGO2_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGO2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGO2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FMR1_DROME	Fmr1	physical	15231716
AGO2_DROME	AGO2	physical	12368261
DCR1_DROME	Dcr-1	physical	12368261
FMR1_DROME	Fmr1	physical	12368261
PPK28_DROME	ppk28	physical	23392611
PSA3_DROME	Prosalpha7	physical	28087276
FMR1_DROME	Fmr1	physical	12368260
FMR1_DROME	Fmr1	physical	14508492
PUM_DROME	pum	physical	24942623
ELP1_DROME	Elp1	physical	19805217
CP190_DROME	Cp190	physical	21852534
DCO_DROME	dco	physical	23392611

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.