PUM_DROME - dbPTM
PUM_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PUM_DROME
UniProt AC P25822
Protein Name Maternal protein pumilio
Gene Name pum
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1533
Subcellular Localization Cytoplasm . It is concentrated in the cortical region of the embryo beneath the nuclei.
Protein Description Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). [PubMed: 1459455]
Protein Sequence MKFLGGNDDRNGRGGVGVGTDAIVGSRGGVSQDAADAAGAAAAAAVGYVFQQRPSPGGVGVGVGGVGGGVPGVGAVGSTLHEAAAAEYAAHFAQKQQQTRWACGDDGHGIDNPDKWKYNPPMNPANAAPGGPPGNGSNGGPGAIGTIGMGSGLGGGGGGGAGGGNNGGSGTNGGLHHQSMAAAAANMAAMQQAAALAKHNHMISQAAAAVAAQQQHQHPHQQHPQQQQQQQQAQNQGHPHHLMGGGNGLGNGNGLGIQHPGQQQQQQQQQQQQQHPGQYNANLLNHAAALGHMSSYAQSGGSMYDHHGGAMHPGMNGGMPKQQPLGPPGAGGPQDYVYMGGQTTVPMGAAMMPPQNQYMNSSAVAAANRNAAITTSTAKKLWEKSDGKGVSSSTPGGPLHPLQIPGIGDPSSVWKDHTWSTQGENILVPPPSRAYAHGGASDTSNSGNAGILSPRDSTCAKVVEYVFSGSPTNKDSSLSGLEPHLRNLKFDDNDKSRDDKEKANSPFDTNGLKKDDQVTNSNGVVNGIDDDKGFNRTPGSRQPSPAEESQPRPPNLLFPPLPFNHMLMDHGQGMGGGLGGVVGSGNGVGGGSGGGGAGGAYAAHQQMAAQMSQLQPPMMNGVGGGMPMAAQSPMLNHQAAGPNHMESPGNLLQQQNFDVQQLFRSQNPGLAAVATNAAAAAAAAAAATSAASAAAAVGAPPVPNGSLQQSQQQQQQQQQQQQQQQMHMAAASQQFLAAQQQAQNAAYAAQQATSYVINPGQEAAPYMGMIAAAQMPYYGVAPWGMYPGNLIPQQGTQPRRPLTPSQQGAENQPYQVIPAFLDHTGSLLMGGPRTGTPMRLVSPAPVLVPPGATRAGPPPPQGPQLYQPQPQTAQQNLYSQQNGSSVGGLALNTSSLTGRRDSFDRSTSAFSPSTMDYTSSGVAAAANAVNSTVAQAAAAAAAAAAARGKWPGAMSGAASGAYGALGAGNASASPLGAPITPPPSAQSCLLGSRAPGAESRQRQQQQQQLAAVGLPATAAAAQAAVAAAANNMFGSNSSIFSNPLAIPGTAAVAAAAAAAAAANSRQVAATAAAAAAVAAAAGGVGGAPQPGRSRLLEDFRNQRYPNLQLRDLANHIVEFSQDQHGSRFIQQKLERATAAEKQMVFSEILAAAYSLMTDVFGNYVIQKFFEFGTPEQKNTLGMQVKGHVLQLALQMYGCRVIQKALESISPEQQQEIVHELDGHVLKCVKDQNGNHVVQKCIECVDPVALQFIINAFKGQVYSLSTHPYGCRVIQRILEHCTAEQTTPILDELHEHTEQLIQDQYGNYVIQHVLEHGKQEDKSILINSVRGKVLVLSQHKFASNVVEKCVTHATRGERTGLIDEVCTFNDNALHVMMKDQYANYVVQKMIDVSEPTQLKKLMTKIRPHMAALRKYTYGKHINAKLEKYYMKITNPITVGTGAGGVPAASSAAAVSSGATSASVTACTSGSSTTTTSTTNSLASPTICSVQENGSAMVVEPSSPDASESSSSVVSGAVNSSLGPIGPPTNGNVVL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
453PhosphorylationSGNAGILSPRDSTCA
CCCCCCCCCCCCCHH		18.9019429919
468PhosphorylationKVVEYVFSGSPTNKD
HHEEHHHCCCCCCCC		28.4619429919
470PhosphorylationVEYVFSGSPTNKDSS
EEHHHCCCCCCCCCC		27.6119429919
472PhosphorylationYVFSGSPTNKDSSLS
HHHCCCCCCCCCCCC		57.5122668510
476PhosphorylationGSPTNKDSSLSGLEP
CCCCCCCCCCCCCCH		34.4819429919
477PhosphorylationSPTNKDSSLSGLEPH
CCCCCCCCCCCCCHH		36.3719429919
505PhosphorylationDDKEKANSPFDTNGL
CHHHHHCCCCCCCCC		31.6321082442
803PhosphorylationTQPRRPLTPSQQGAE
CCCCCCCCHHHCCCC		24.4723607784
805PhosphorylationPRRPLTPSQQGAENQ
CCCCCCHHHCCCCCC		29.8723607784
842PhosphorylationGTPMRLVSPAPVLVP
CCCCEEECCCCEECC		21.6725749252
902PhosphorylationSLTGRRDSFDRSTSA
CCCCCCCCCCCCCCC		27.5119429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PUM_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PUM_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PUM_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DIAP1_DROMEthgenetic
27256879
HID_DROMEWgenetic
27256879
RAS1_DROMERas85Dgenetic
22514614
NANOS_DROMEnosgenetic
1908748
DLG1_DROMEdlg1physical
18463699
ERKA_DROMErlphysical
22514614
CUP_DROMEcupphysical
11274060
SOS_DROMESosphysical
22514614
BRAT_DROMEbratphysical
11274060
BRAT_DROMEbratphysical
17055983
BRAT_DROMEbratphysical
17360772
BRAT_DROMEbratphysical
11336677
CAD_DROMEcadphysical
16537387
DRK_DROMEdrkphysical
22514614
MAM_DROMEmamphysical
18463699
NOL9_DROMECG8414physical
16537387
PABP_DROMEpAbpphysical
24942623
EGFR_DROMEEgfrphysical
22514614
CCNB_DROMECycBphysical
17360772
CCNB_DROMECycBphysical
18463699
CCNB_DROMECycBphysical
27482653
DCE_DROMEGad1physical
18463699
AGO2_DROMEAGO2physical
24942623
HID_DROMEWphysical
27256879
DNJC5_DROMECspphysical
18463699
BCD_DROMEbcdphysical
27482653
HUNB_DROMEhbphysical
10541556
HUNB_DROMEhbphysical
11303521
HUNB_DROMEhbphysical
11336677
HUNB_DROMEhbphysical
15541314
HUNB_DROMEhbphysical
17360772
HUNB_DROMEhbphysical
18463699
HUNB_DROMEhbphysical
19372537
HUNB_DROMEhbphysical
22514614
HUNB_DROMEhbphysical
24286029
HUNB_DROMEhbphysical
27482653
HUNB_DROMEhbphysical
7889568
HUNB_DROMEhbphysical
9404893
HUNB_DROMEhbphysical
9660969
ACES_DROMEAcephysical
18463699
NANOS_DROMEnosphysical
10541556
NANOS_DROMEnosphysical
11274060
NANOS_DROMEnosphysical
17055983
NANOS_DROMEnosphysical
17360772
NANOS_DROMEnosphysical
24286029
NANOS_DROMEnosphysical
11336677
VATL_DROMEVha16-1physical
16537387
PLU_DROMEpluphysical
16537387
IF4E_DROMEeIF-4Ephysical
15541314
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PUM_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453; SER-468; SER-470;SER-477 AND SER-505, AND MASS SPECTROMETRY.

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