DRK_DROME - dbPTM
DRK_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DRK_DROME
UniProt AC Q08012
Protein Name Protein enhancer of sevenless 2B
Gene Name drk
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 211
Subcellular Localization Membrane
Peripheral membrane protein .
Protein Description Required for proper signaling by sevenless. May act to stimulate the ability of Sos to catalyze Ras1 activation by linking sevenless and Sos in a signaling complex..
Protein Sequence MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGRITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLWVVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDENWWNGEIGNRKGIFPATYVTPYHS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster

Oops, there are no PTM records of DRK_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DRK_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DRK_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DRK_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DORS_DROMEdlphysical
14605208
PFD5_DROMECG7048physical
14605208
SRC64_DROMESrc64Bphysical
14605208
DAB_DROMEDabphysical
9671493
DYN_DROMEshiphysical
10918586
KRAF1_DROMEphlgenetic
19244537
SOS_DROMESosgenetic
25099352
RAS1_DROMERas85Dgenetic
19244537
DIP2_DROMEDIP2physical
22028469
MOODY_DROMEmoodyphysical
22028469
KRAF1_DROMEphlphysical
22028469
C3G_DROMEC3Gphysical
22028469
7LESS_DROMEsevphysical
8462098
AJUBA_DROMEjubphysical
22028469
BSG2_DROMEBsg25Dphysical
22028469
SOS_DROMESosphysical
22028469
SOS_DROMESosphysical
9671493
DORS_DROMEdlphysical
22028469
PKN_DROMEPknphysical
22028469
1433Z_DROME14-3-3zetaphysical
22028469
PR2_DROMEAck-likephysical
22028469
EGFR_DROMEEgfrphysical
22028469
EGFR_DROMEEgfrphysical
7601354
EGFR_DROMEEgfrphysical
7651398
DOS_DROMEdosphysical
22028469
DOS_DROMEdosphysical
12128212
SPY_DROMEstyphysical
22028469
LARK_DROMElarkphysical
22028469
DAB_DROMEDabphysical
22028469
CYFIP_DROMESra-1physical
22028469
1433E_DROME14-3-3epsilonphysical
22028469
RGS_DROMElocophysical
22028469
CAD96_DROMECad96Caphysical
24522188
ATPB_DROMEATPsyn-betaphysical
22028469
CSW_DROMEcswphysical
22028469
DYN_DROMEshiphysical
22028469

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DRK_DROME

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Related Literatures of Post-Translational Modification

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