DOS_DROME - dbPTM
DOS_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOS_DROME
UniProt AC Q9VZZ9
Protein Name Protein daughter of sevenless
Gene Name dos
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 878
Subcellular Localization Cytoplasm . Membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Essential component for signaling from various receptor tyrosine kinases such as Sevenless, TORSO and DER. Required for photoreceptor cell and wing development..
Protein Sequence MDRTFYEGWLIKSPPTKRIWRARWRRRYFTLKQGEIPEQFCLEYYTDHNCRKLKGVIDLDQCEQVDCGLRLENRKQKFQYMFDIKTPKRTYYLAAETEADMRDWVNCICQVCHLHDTKQSNELPLGAVGADENRTQHTSSSGGLSNSTQNTTTTSLHSSAGTTAPQASVPNAGGSAQLRRPAVIEEQPMPSNAGNNNSDSVYVNTEYSNRETMLCDANFDQQELLSAAQQQPPPSPATALYLNHSALIQAQAAAAAAEQLQQQQQQAARLAVSANGVVRKLPEHLVLTQQTLAEAAAQQHSSVQASPALSTASGPYIPISECFSGSPRFLPGVPLPGADLAIPNNPTTPLNNLDPKFYDTPRSHNNIGLNLTNDQSYSPKITNLSLQQLANNNASKQRSDSDSESVFTDDDEWAHPLPLRENVDRSTRPSDSSIENESFVLTYSQRFSKMPEEGGAIVPPAEKSSKLAGAASLPEAGDQGTLDKLAKVLKNKNNLILDFKENEKIPRDLPQLSDTENTSPAIVARRNAHSAFIEESYDIPRSHQQPYYNVNQLLGERPVTSPHNSNPIAASTPNLMAADLGAVAAISAAANPGLMGEAQAVASSPTSARTLPRHCYTNAAPTKMEGNVFRYDFMEQADCPPVNRKLKPKVAGGLPVVEDKPPEEFPAKPPVGVDQLTNKLGAAQLQQPIGPPSVDRKCKPNAYKLGNSATMSPATRRSSGAPLSMVLPHETDVHSPAAANAFFHETRTLPRQQHRHHPNSPGSMSVQHQRTASAAAAMMSLTAAAAPKQQAAAQTEHKLQYFDLDVTNKPPLLNRSSMSVGNLYSQGGNGASGMRFAGVEAGGARAPVPSSVVYRSVDFVKTEAFKRIREERESSGNK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
347PhosphorylationLAIPNNPTTPLNNLD
EECCCCCCCCCCCCC		43.0719429919
348PhosphorylationAIPNNPTTPLNNLDP
ECCCCCCCCCCCCCH		27.3419429919
358PhosphorylationNNLDPKFYDTPRSHN
CCCCHHHCCCCCCCC		25.6518281928
360PhosphorylationLDPKFYDTPRSHNNI
CCHHHCCCCCCCCCC		14.8227626673
376PhosphorylationLNLTNDQSYSPKITN
EECCCCCCCCCCCCH		30.3719429919
377PhosphorylationNLTNDQSYSPKITNL
ECCCCCCCCCCCCHH		24.2919429919
378PhosphorylationLTNDQSYSPKITNLS
CCCCCCCCCCCCHHH		25.6019429919
385PhosphorylationSPKITNLSLQQLANN
CCCCCHHHHHHHHCC		26.6319429919
399PhosphorylationNNASKQRSDSDSESV
CCCCCCCCCCCCCCC		38.6822817900
401PhosphorylationASKQRSDSDSESVFT
CCCCCCCCCCCCCCC		44.2622668510
433PhosphorylationSTRPSDSSIENESFV
CCCCCCCCCCCCEEE		38.6222817900
481PhosphorylationPEAGDQGTLDKLAKV
CCCCCCCHHHHHHHH		26.5919429919
513PhosphorylationPRDLPQLSDTENTSP
CCCCCCCCCCCCCCH		36.9219429919
515PhosphorylationDLPQLSDTENTSPAI
CCCCCCCCCCCCHHH		27.9719429919
518PhosphorylationQLSDTENTSPAIVAR
CCCCCCCCCHHHHHH		29.8329892262
519PhosphorylationLSDTENTSPAIVARR
CCCCCCCCHHHHHHH		24.7419429919
530PhosphorylationVARRNAHSAFIEESY
HHHHCCCHHHHHHCC		23.5919429919
536PhosphorylationHSAFIEESYDIPRSH
CHHHHHHCCCCCHHH		18.4719429919
537PhosphorylationSAFIEESYDIPRSHQ
HHHHHHCCCCCHHHC		22.6019429919
616PhosphorylationRTLPRHCYTNAAPTK
CCCCCCCCCCCCCCC		9.2622817900
617PhosphorylationTLPRHCYTNAAPTKM
CCCCCCCCCCCCCCE		24.6318281928
715PhosphorylationSATMSPATRRSSGAP
CCCCCHHHCCCCCCC		29.9627626673
718PhosphorylationMSPATRRSSGAPLSM
CCHHHCCCCCCCCEE		29.8121082442
719PhosphorylationSPATRRSSGAPLSMV
CHHHCCCCCCCCEEE		36.8421082442
760PhosphorylationQHRHHPNSPGSMSVQ
CCCCCCCCCCCCCHH		34.7822817900
771PhosphorylationMSVQHQRTASAAAAM
CCHHHHHHHHHHHHH		20.5623607784
773PhosphorylationVQHQRTASAAAAMMS
HHHHHHHHHHHHHHH		20.1623607784
801PhosphorylationQTEHKLQYFDLDVTN
HCCHHHHCCCCCCCC		14.9719429919
807PhosphorylationQYFDLDVTNKPPLLN
HCCCCCCCCCCCCCC		36.8722817900
824PhosphorylationSMSVGNLYSQGGNGA
CCCCCCCCCCCCCCC		11.7118281928
851PhosphorylationARAPVPSSVVYRSVD
CCCCCCCCCEEECCC		14.9929892262
854PhosphorylationPVPSSVVYRSVDFVK
CCCCCCEEECCCCHH		8.6025749252
874PhosphorylationRIREERESSGNK---
HHHHHHHHCCCC---		50.1721082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DOS_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOS_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOS_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CHMP5_DROMECG6259physical
22036573
IRS1_DROMEchicophysical
22036573
FLOT2_DROMEFlo2physical
22036573
ACTN_DROMEActnphysical
22028469
RL17_DROMERpL17physical
22028469
ADT_DROMEsesBphysical
22028469
CAZ_DROMEcazphysical
22028469
CAPZB_DROMEcpbphysical
22028469
1433Z_DROME14-3-3zetaphysical
22028469
CAPZA_DROMEcpaphysical
22028469
HSP83_DROMEHsp83physical
22028469
HSP7A_DROMEHsc70-1physical
22028469
U520_DROMEl(3)72Abphysical
22028469
EI3F1_DROMECG9769physical
22028469
FLNA_DROMEcherphysical
22028469
CSW_DROMEcswphysical
22028469
TTF2_DROMEldsphysical
22028469
PP2B3_DROMECanA-14Fphysical
22028469
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOS_DROME

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-399, AND MASSSPECTROMETRY.
"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-481; THR-771 ANDTYR-801, AND MASS SPECTROMETRY.
"Recruitment of the protein tyrosine phosphatase CSW by DOS is anessential step during signaling by the sevenless receptor tyrosinekinase.";
Herbst R., Zhang X., Qin J., Simon M.A.;
EMBO J. 18:6950-6961(1999).
Cited for: PHOSPHORYLATION AT TYR-801 AND TYR-854.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory