U520_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U520_DROME
• UniProt AC: Q9VUV9
• Protein Name: Putative U5 small nuclear ribonucleoprotein 200 kDa helicase
• Gene Name: l(3)72Ab
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2142
• Subcellular Localization: Nucleus .
• Protein Description: Putative RNA helicase involved in the second step of RNA splicing..
• Protein Sequence: MADAAARQLQYEYKANSNLVLQADVRLIERPRRDEATGEVCSLVGKLDGTRMGDRYQRTKPEKTEERKVKRQKRDEAQYDFERMKGATLLSEGIDEMVGIVYRPKTQETRQTYEVLLSFIQEALGDQPRDILCGAADEILAVLKNDRLKDRERKKDIDSLLGAVTDERFALLVNLGKKITDFGSDAVNALTAAPNNEEQIDETYGINVQFEESEEESDNDMYGEIRDDDAQDEGEEARIDHTLHAENLANEEAANNVKKERSLHPLDIDAYWLQRCLSKFYKDAMVSQSKAADVLKILKDAADDRDCENQLVLLLGYDCFDFIKQLKLNRQMVLYCTMLASAQTDSERQRIREKMRGNSALAKILRQLDTGKSEDQEEGEARGSKRGKGDAEDGGAAAAGQVAGVRQLLELEEMAFTQGSHFMANKRCQLPDGSYRKQRKGYEEVHVPALKPVPFDANEELQPVDKLPKYVQPVFEGFKTLNRIQSRLYKAALDSDENMLLCAPTGAGKTNVALLTMMREIGKHINEDGTINAQDFKIIYVAPMKSLVQEMVGNFGRRLACYNLTVSELTGDHQLTREQIAATQVIVCTPEKWDIITRKGGERTFVSLVRLVIIDEIHLLHDERGPVLEALVARTIRNIETTQEEVRLVGLSATLPNYQDVATFLRVKPDKGLFYFDNSYRPVSLEQQYIGVTEKKALKRFQVMNEIVYEKTMEHAGRNQVLVFVHSRKETGKTARAVRDMCLEQDTLGSFLKEGSASMEVLRTEAEQVKNTELKELLPYGFAIHHAGMTRVDRTLVEDLFADRHIQVLVSTATLAWGVNLPAHTVIIKGTQVYNPEKGRWVELSALDVLQMLGRAGRPQYDTKGEGILITNHSELQFYLSLLNQQLPIESQFISKLPDMLNAEIVLGTVQHLQDAVNWLGYTYLYIRMLRNPTLYGVSHDAIKADPLLEQHRADLLHTAACCLERSGLIKYDRKTGHFQVTDLGRIASHYYLTHETMLTYNQLLKQTLSEIELFRVFSLSSEFRHISVREEEKLELQKLMERVPIPIKESIEEHSAKVNVLLQAYISQLKLEGFALMSDMVFITQSAARLMRAIFEIVLTRGWAQLADKTLTLCKMIDRRMWQSMTPLRQFKKMPDEIAKKLEKKHFPWGRLYDLEPHELGELIRVPKLGKTIHKFVHQFPKLELSTHIQPITRGTLRVELTITPDFQWDEKVHGQSEGFWVLIEDVDSELILHHEFFLLKQKYSQDEHQLKFFVPVFEPLPPQYFLRIVSDRWIGAETQLPVSFRHLILPEKNMPPTELLDLQPLPISALRQPKFESFYSQRFPQFNPIQTQVFNAVYNSDENVFVGAPTGSGKMTIAEFAIMRLFTTQSDARCVYLVSEEALADLVFADWHSKFGSLDIKVVKLTGETGTDLKLIAKGQLVITTADKWDVLSRRWKQRKNVQLVNLFIVDELQLVGGEEGPVLEIVCSRMRYISSQIEKQIRIVALSASLTDARDVAQWLGCNPNATFNFHPSVRPIPLELHIQGYNVTHNATRIATMSKPVYNAILKYSAHKPVIVFVSSRKQARLTAIDVLTYAASDLQPNRFFHAEEEDIKPFLERMTDKTLKETLAQGVAYLHEGLSASDHRLVEQLFDSGAVQVAVISRDLCWGMSISAHLVIIMDTQFYNGKNHSYEDYPITDVLQMIGRANRPNEDADAKCVLMCQSSKKDFFKKFINEPLPIESHLDHRMHDHFNAEVVTKTIENKQDAVDYLTWTFLYRRLTQNPNYYNLQGVTHRHLSDHLSELVENTLSDLEQSKCISVEDDMDTLPLNLGMIAAYYYINYTTIELFSLSLNSKTKVRGLLEIISSAAEYEDVVVRHHEEQVLRTLSQRLPNKLTGPNETAPKFNDPHIKTNLLLQAHLSRLQLGPELQGDTEQILSKAIRLIQACVDVLSSNGWLSPAVAAMELAQMVTQAMWSKDSYLKQLPHFSPEIVKRCTEKKIETVFDIMELEDEDRTRLLQLSDLQMADVARFCNRYPNIELNYEVVDKDRINSGSTVNVVVQLEREDEVTGPVIAPFFPQKREEGWWVVIGDPKTNSLLSIKRLTLQQKAKVKLDFVAPSPGKHDYTLYYMSDSYLGCDQEYKFSIEVGDFQSESESESD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
242	Phosphorylation	EEARIDHTLHAENLA HHHHHHHHHHHHHHC	19.25	18327897
1352	Phosphorylation	NVFVGAPTGSGKMTI CEEEECCCCCCCHHH	43.37	22817900
1354	Phosphorylation	FVGAPTGSGKMTIAE EEECCCCCCCHHHHH	37.41	22817900
1358	Phosphorylation	PTGSGKMTIAEFAIM CCCCCCHHHHHHHHH	22.11	22817900
2135	Phosphorylation	IEVGDFQSESESESD EEECCCCCCCCCCCC	42.98	19429919
2137	Phosphorylation	VGDFQSESESESD-- ECCCCCCCCCCCC--	52.23	19429919
2139	Phosphorylation	DFQSESESESD---- CCCCCCCCCCC----	52.24	19429919
2141	Phosphorylation	QSESESESD------ CCCCCCCCC------	58.88	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U520_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U520_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U520_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECD_DROME	ecd	physical	24722212

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.