dbPTM

CSW_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CSW_DROME
UniProt AC	P29349
Protein Name	Tyrosine-protein phosphatase corkscrew
Gene Name	csw
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	845
Subcellular Localization	Cytoplasm.
Protein Description	Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw. Dephosphorylates drpr isoform A which is required for the inhibition by drpr isoform A of glial cell engulfment of axonal debris produced following axonal injury. [PubMed: 22426252]
Protein Sequence	MSSRRWFHPTISGIEAEKLLQEQGFDGSFLARLSSSNPGAFTLSVRRGNEVTHIKIQNNGDFFDLYGGEKFATLPELVQYYMENGELKEKNGQAIELKQPLICAEPTTERWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTGMGLSMGVGMGVGNKHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLGGIGLGLGGNMRKSNFYSDSLKQQQQREEQAPAGAGKMQQPAPPLRPRPGILKLLTSPVIFQQNSKTFPKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
419	Phosphorylation	VGLLKRHSNDSSGAV HHHHHHCCCCCCCCE	46.49	12694293
422	Phosphorylation	LKRHSNDSSGAVSIS HHHCCCCCCCCEEHH	34.62	22817900
682	Phosphorylation	IGNDSQRSPLPPAIS CCCCCCCCCCCCCCC	24.13	29892262
791	Phosphorylation	NMRKSNFYSDSLKQQ CCCCCCCCCHHHHHH	18.80	18281928

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CSW_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CSW_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CSW_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DOS_DROME	dos	physical	9582352
DSOR1_DROME	Dsor1	genetic	8381718
DSOR1_DROME	Dsor1	genetic	16399795
JAK_DROME	hop	genetic	16399795
STAR_DROME	S	genetic	11014820
STAR_DROME	S	genetic	16399795
STAR_DROME	S	genetic	18849586
DECA_DROME	dpp	genetic	16399795
MAD_DROME	Mad	genetic	16399795
SOS_DROME	Sos	genetic	11014820
SOS_DROME	Sos	genetic	16399795
SOS_DROME	Sos	genetic	18849586
SUH_DROME	Su(H)	genetic	16399795
SPITZ_DROME	spi	genetic	18849586
DRK_DROME	drk	genetic	11014820
DRK_DROME	drk	genetic	16399795
SMUF1_DROME	lack	genetic	16399795
MGN_DROME	mago	genetic	20946983
EGFR_DROME	Egfr	genetic	11014820
EGFR_DROME	Egfr	genetic	16399795
EGFR_DROME	Egfr	genetic	18849586
SRF_DROME	bs	genetic	16399795
SRF_DROME	bs	genetic	11014820
RHOM_DROME	rho	genetic	16399795
DOS_DROME	dos	genetic	8681384
DOS_DROME	dos	genetic	10601017
DOS_DROME	dos	genetic	11014820
HSP83_DROME	Hsp83	genetic	16399795
SPY_DROME	sty	genetic	16399795
SPY_DROME	sty	genetic	18849586
SPY_DROME	sty	genetic	16481357
VEIN_DROME	vn	genetic	16399795
VEIN_DROME	vn	genetic	18849586
GAP1_DROME	RasGAP1	genetic	16399795
GAP1_DROME	RasGAP1	genetic	18849586
GAP1_DROME	RasGAP1	genetic	11014820
GIL_DROME	aos	genetic	16399795
GIL_DROME	aos	genetic	18849586
RAS1_DROME	Ras85D	genetic	11014820
RAS1_DROME	Ras85D	genetic	16399795
RAS1_DROME	Ras85D	genetic	18849586
DL_DROME	Dl	genetic	16399795
STAT_DROME	Stat92E	genetic	16399795
PNT1_DROME	pnt	genetic	11014820
PNT2_DROME	pnt	genetic	11014820
PNT1_DROME	pnt	genetic	16399795
PNT2_DROME	pnt	genetic	16399795
ESM8_DROME	E(spl)m8-HLH	genetic	16399795
SRC64_DROME	Src64B	genetic	11014820
ANKHM_DROME	mask	genetic	11782402
ERKA_DROME	rl	genetic	11014820
ERKA_DROME	rl	genetic	16399795
ERKA_DROME	rl	genetic	18849586
CH60_DROME	Hsp60	physical	22028469
RL371_DROME	RpL37a	physical	22028469
CAZ_DROME	caz	physical	22028469
IF4A_DROME	eIF-4a	physical	22028469
DOS_DROME	dos	physical	22028469
HSP83_DROME	Hsp83	physical	22028469
Y1505_DROME	CG11505	physical	22028469
KPYK_DROME	PyK	physical	22028469
TCPA_DROME	T-cp1	physical	22028469
ATPB_DROME	ATPsyn-beta	physical	22028469
RL37A_DROME	RpL37A	physical	22028469

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CSW_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419, AND MASSSPECTROMETRY.	18327897 [Abstract]