dbPTM

GIL_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GIL_DROME
UniProt AC	Q00805
Protein Name	Protein giant-lens
Gene Name	aos
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	444
Subcellular Localization	Secreted .
Protein Description	Regulates cell determination; development of ommatidia and optic lobe. Is a signaling molecule involved in the process of axon pathfinding in the eye. Part of the Ras pathway regulating programmed cell death in pupal eyes; activated by lozenge (lz). Antagonist for the Egfr receptor (gurken). Inhibits Egfr signaling without interacting directly with the receptor, but instead by sequestering the Egfr-activating ligand spitz (spi)..
Protein Sequence	MPTTLMLLPCMLLLLLTAAAVAVGGTRLPLEVFEITPTTSTADKHKSLQYTVVYDAKDISGAAAATGVASSTVKPATEQLTVVSISSTAAAEKDLAESRRHARQMLQKQQQHRSIIGGKHGDRDVRILYQVGDSEEDLPVCAPNAVCSKIDLYETPWIERQCRCPESNRMPNNVIIHHHSHSSGSVDSLKYRNYYEREKMMQHKRMLLGEFQDKKFESLHMKKLMQKLGAVYEDDLDHLDQSPDYNDALPYAEVQDNEFPRGSAHMRHSGHRGSKEPATTFIGGCPSSLGVEDGHTIADKTRHYKMCQPVHKLPVCTHFRDYTWTLTTAAELNVTEQIVHCRCPRNSVTYLTKREPIGNGSPGYRYLFACSPLTRLRCQRKQPCKLFTVRKRQEFLDEVNINSLCQCPKGHRCPSHHTQSGVIAGESFLEDNIQTYSGYCMAND

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
333	N-linked_Glycosylation	LTTAAELNVTEQIVH EEECEECCCCEEEEE	30.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GIL_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GIL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GIL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KRAF1_DROME	phl	genetic	8812105
FAS2_DROME	Fas2	genetic	19141676
DSOR1_DROME	Dsor1	genetic	8812105
LOZEN_DROME	lz	genetic	15879554
VAV_DROME	Vav	genetic	25813543
EBI_DROME	ebi	genetic	15998720
EBI_DROME	ebi	genetic	22041576
STAR_DROME	S	genetic	8812105
STAR_DROME	S	genetic	10747059
STAR_DROME	S	genetic	8834476
SALM_DROME	salm	genetic	11171397
CWC22_DROME	ncm	genetic	15998720
DIAP2_DROME	Iap2	genetic	10200472
EGFR_DROME	Egfr	genetic	7651519
EGFR_DROME	Egfr	genetic	11944933
EGFR_DROME	Egfr	genetic	14507782
RNO_DROME	rno	genetic	14704181
RHOM_DROME	rho	genetic	8026629
SPY_DROME	sty	genetic	10089881
SPY_DROME	sty	genetic	10226010
SPY_DROME	sty	genetic	10747059
VEIN_DROME	vn	genetic	10588875
DIAP1_DROME	th	genetic	10200472
HPS5_DROME	p	genetic	21746852
RAS1_DROME	Ras85D	genetic	8812105
RAS1_DROME	Ras85D	genetic	10200472
RAS1_DROME	Ras85D	genetic	14507782
DL_DROME	Dl	genetic	11944933
PNT1_DROME	pnt	genetic	14507782
PNT2_DROME	pnt	genetic	14507782
HRD1_DROME	sip3	genetic	21439629
RHDF1_DROME	rho-5	genetic	21439629
ERKA_DROME	rl	genetic	8812105
RL5_DROME	RpL5	genetic	15998720
RL38_DROME	RpL38	genetic	15998720

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GIL_DROME

Related Literatures of Post-Translational Modification