| UniProt ID | LOZEN_DROME | |
|---|---|---|
| UniProt AC | Q9W349 | |
| Protein Name | Protein lozenge | |
| Gene Name | lz | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 826 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Involved in prepatterning photoreceptor precursors in the developing eye; in the larval eye disk it defines a subset of cells as an equipotential group that is competent to respond to the sevenless developmental signal and another subset that confer proper photoreceptor identity by positively regulating the homeo box gene Bar. Involved in the aop/pnt dynamic in a Ras-dependent manner to regulate pros expression. Promotes apoptosis in the pupal eye by directly activating aos and klu. Also modulates hid- and rpr-mediated cell death. Regulates amos function in olfactory sensilla development.. | |
| Protein Sequence | MHLHLLAAEKTPPSPSPNPTPTPSASPSGHTGAAGESQLDLASQTESQLQLGLPLASGYGLGLGLGLGLGLGLGQELVADHSTTVAPVSVAGPGRLGRSINGSGGSHHHHHLHHHYSPYHHAHPYHPPHPHAPHHHHHHHPPYPYPPAGPHPPAMVTSSSTSPTGNGWSSSTGDFKGITAVATATGGGVGGATQGATASTGATAAEVLAVSSSASVGSSSPTGGASNGTAHSGHSGHTGGHSSSTASNNNNNGASNSNSNNNNAVHQDLLWMERLVQKRQQEHPGELVRTSNPYFLCSALPAHWRSNKTLPMAFKVVALAEVGDGTYVTIRAGNDENCCAELRNFTTQMKNDVAKFNDLRFVGRSGRGKSFTLTITVATSPPQVATYAKAIKVTVDGPREPRSKTSPTGGPHYRALGLGQRPYIDGFPSTKALHELESLRRSAKVAAVTTAAAAAATAASAANAVAAAAAAVAVTPTGGGGGVAAGGVAGGAGAGLVQQLSSNYSSPNSTINSDCQVYKPNAPHIQAAEMMGAGEWTNGSSSSAAAYYHSHAHHPHAHHAHAHLQHQMALPPPPPPPAAAPVSVGVGGNGATMGMGMGVGVGMGMNHYGGGYDSANSLEAGQYAAHLPAVLPEMHGHGFATDPYQTAGYGGGNTGGGSASKSELDYGGSYNQAWSNGYQNYQYGSCLATAQYGPQAAPPPQPPPPPPVVLCPQLYSTVNQNQIHLHLHSSEKLEQYLGTATSADHLTIGSLTGSSRSSIEIGQDQYHQQVHHAQQQQQQQQQQQQVHHPQQQQVESAGEVGGSGAGGVESAREEDVGDLSQVWRPY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|
|---|---|---|---|---|---|---|
Oops, there are no PTM records of LOZEN_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LOZEN_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LOZEN_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LOZEN_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZEST_DROME | z | genetic | 8295076 | |
| POK_DROME | aop | genetic | 12111211 | |
| AMOS_DROME | amos | genetic | 10707973 | |
| BGB_DROME | Bgb | genetic | 11526071 | |
| BGB_DROME | Bgb | genetic | 10393111 | |
| BRO_DROME | Bro | genetic | 10393111 | |
| HSP83_DROME | Hsp83 | genetic | 11526071 | |
| RAS1_DROME | Ras85D | genetic | 12111211 | |
| SRP_DROME | srp | genetic | 14504400 | |
| OSA_DROME | osa | genetic | 11526071 | |
| MMD4_DROME | mod(mdg4) | genetic | 2558282 | |
| SUF_DROME | su(f) | genetic | 1355750 | |
| SUF_DROME | su(f) | genetic | 12690448 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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