SRP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRP_DROME
• UniProt AC: P52172
• Protein Name: Box A-binding factor
• Gene Name: srp
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1264
• Subcellular Localization: Nucleus.
• Protein Description: May function as a transcriptional activator protein and may play a key role in the organogenesis of the fat body. Binds a sequence element (5'-[TA]GATAA-3') found in the larval promoters of all known alcohol dehydrogenase (ADH) genes. Acts as a homeotic gene downstream of the terminal gap gene HKB to promote morphogenesis and differentiation of anterior and posterior midgut..
• Protein Sequence: MTKTTKPKEKAAAGGAVIGSGSGLGSVTKAGGGSLLSNAADSKIRTAKSNNNKRQAGRAATALAATTTASALAATTTAGATGSNAAANETEIAIETENGEAATPTAAATAAAANLSSLESARSQALTSVVSETARQAVTTANASATSTSTVTAATEIATATASDTAATSEAAIDDDPSAINTNNNNNNSKAQNDASESVKTKVISYHQSEDQQQQQQQQAQIYEQQQQFLSQQLISHHQQEQHQQAQQQQHQQVVQEQHQASWLAYDLTSGSAAAAAAAAAAASHPHLFGQFSYPPSHHTPTQLYEHYPSTDPIMRNNFAFYSVYTGGGGGVGVGMTSHEHLAAAAAAAAAVAQGTTPNIDEVIQDTLKDECFEDGHSTDYHVLTSVSDMHTLKDSSPYALTHEQLHQQQHHHQQQLHHHQQQQQQLYHQQQQQQQQQQHHHHHNNSTSSAGGDSPSSSHALSTLQSFTQLTSATQRDSLSPENDAYFAAAQLGSSLQNSSVYAGSLLTQTANGIQYGMQSPNQTQAHLQQQHHQQQQQQHQQHQQQQLQQQQQQHHHNQHQHHNSSSSSPGPAGLHHSSSSAATAAAVAAATAAVNGHNSSLEDGYGSPRSSHSGGGGGGTLPAFQRIAYPNSGSVERYAPITNYRGQNDTWFDPLSYATSSSGQAQLGVGVGAGVVSNVIRNGRAISAANAAAAAAADGTTGRVDPGTFLSASASLSAMAAESGGDFYKPNSFNVGGGGRSKANTSGAASSYSCPGSNATSAATSAVASGTAATAATTLDEHVSRANSRRLSASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKRKRKPKGTKSEKSKSKSKNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDDMKPQLDLKPYNSYSSQPQQQLPQYQQQQQLLMADQHSSAASSPHSMGSTSLSPSAMSHQHQTHPHQQQQQQLCSGLDMSPNSNYQMSPLNMQQHQQQQSCSMQHSPSTPTSIFNTPSPTHQLHNNNNNNNNSSIFNNNNNNNSSSNENNNKLIQKYLQAQQLSSSSNSGSTSDHQLLAQLLPNSITAAAAAAAAAAAAAIKTEALSLTSQANCSTASAGLMVTSTPTTASSTLSSLSHSNIISLQNPYHQAGMTLCKPTRPSPPYYLTPEEDEQPALIKMEEMDQSQQQQQQQQHQQQQHGEIMLSRSASLDEHYELAAFQRHQQQQQQLQQQTAALLGQHEQHVTNYAMHKFGVDRETVVKME

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
612	Phosphorylation	DGYGSPRSSHSGGGG CCCCCCCCCCCCCCC	35.47	19429919
613	Phosphorylation	GYGSPRSSHSGGGGG CCCCCCCCCCCCCCC	23.97	19429919
615	Phosphorylation	GSPRSSHSGGGGGGT CCCCCCCCCCCCCCC	40.87	19429919
622	Phosphorylation	SGGGGGGTLPAFQRI CCCCCCCCCCCHHEE	32.61	19429919
1159	Phosphorylation	GMTLCKPTRPSPPYY CCCCCCCCCCCCCCC	40.48	19429919
1162	Phosphorylation	LCKPTRPSPPYYLTP CCCCCCCCCCCCCCC	34.90	19429919
1206	Phosphorylation	QHGEIMLSRSASLDE HHHHHHHCCCCCHHH	13.55	22817900
1208	Phosphorylation	GEIMLSRSASLDEHY HHHHHCCCCCHHHHH	20.87	19429919
1210	Phosphorylation	IMLSRSASLDEHYEL HHHCCCCCHHHHHHH	37.28	19429919
1215	Phosphorylation	SASLDEHYELAAFQR CCCHHHHHHHHHHHH	15.58	23607784

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LOZEN_DROME	lz	genetic	14504400
LOZEN_DROME	lz	genetic	14657024
USH_DROME	ush	genetic	8946251
USH_DROME	ush	genetic	14504400
KRUP_DROME	Kr	genetic	22252491
RS29_DROME	RpS29	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1208 AND SER-1210, ANDMASS SPECTROMETRY.
PubMed: 18327897