POK_DROME - dbPTM
POK_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID POK_DROME
UniProt AC Q01842
Protein Name Ets DNA-binding protein pokkuri
Gene Name aop
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 732
Subcellular Localization Nucleus . In undifferentiated cells during the early stages of eye development.
Protein Description Ets-related protein that functions as a negative regulator of photoreceptor development acting antagonistically to pnt and the proneural signal mediated by RAS. [PubMed: 1505027]
Protein Sequence MSKMKMLPVQLSLNSLNPGIWSDVLWRCPPAPSSQLAELKTQLPPSLPSDPRLWSREDVLVFLRFCVREFDLPKLDFDLFQMNGKALCLLTRADFGHRCPGAGDVLHNVLQMLIIESHMMQWHLPNSPVTPTSRYPLSPHSHPPTPTWPPLNAPPENSPFHSSAHSLAGHHFMAPNSVTLSPPPSVDSQASSPPQAPYQNGGATGAAPGSAGGSAPAAGGATNTSNPTSSSASSTGSNGSQPNIMPMKGISSASSNHSDSEEEYSETSGGVSKMPPAPLSYSTASPPGTPILKDIKPNWTQQLTNSFVNSWSQQQQQQQQQQAAAVAAVAAQAQQHQLQQQQQQQQLPQKLTLDNTAGPVVTPAGGSISAPTTPSYMYKAKREFFPENSEPNTNGRLLWDFLQQLLNDRNQKYSDLIAWKCRDTGVFKIVDPAGLAKLWGIQKNHLSMNYDKMSRALRYYYRVNILRKVQGERHCYQFLRNPTELKNIKNISLLRQSTPANGNGGSPSMPQGSSQAPGSPAGQNWNPQQQSQQQQQSPQRPASRNGPMSLPAVAAVAAAAAAAYGPPPTSPLFMHAINGAFHYLSAAAAGPPPNSPALNTPSAVGGPDKFQFHPLKLENGSGSGSESAGEDLKPTDLSVSSKSTATSNEDCYPLIRNADGLTTIKLIRYNEHQVAASPAGQSPKHDDQQAGASNASSSPRPMDQASEQAQPVPMESDCNGGESEDSFRHMQQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
127PhosphorylationMQWHLPNSPVTPTSR
CCCCCCCCCCCCCCC		20.8611357138
281PhosphorylationMPPAPLSYSTASPPG
CCCCCCCCCCCCCCC		20.0921082442
285PhosphorylationPLSYSTASPPGTPIL
CCCCCCCCCCCCCCC		31.5419429919
289PhosphorylationSTASPPGTPILKDIK
CCCCCCCCCCCCCCC		16.9619429919
537PhosphorylationQSQQQQQSPQRPASR
HHHHHHHCCCCCHHH		20.7522817900
543PhosphorylationQSPQRPASRNGPMSL
HCCCCCHHHCCCCCH		29.0322817900
665AcetylationADGLTTIKLIRYNEH
CCCCEEEEEEEECCC		35.4521791702
677PhosphorylationNEHQVAASPAGQSPK
CCCCEECCCCCCCCC		12.9219429919
682PhosphorylationAASPAGQSPKHDDQQ
ECCCCCCCCCCCCCC		34.6919429919
696PhosphorylationQAGASNASSSPRPMD
CCCCCCCCCCCCCCC		35.2818327897
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
127SPhosphorylationKinaseMAPK-FAMILY-GPS
127SPhosphorylationKinaseMAPK_GROUP-PhosphoELM
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of POK_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of POK_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NOTCH_DROMENgenetic
8575295
LOZEN_DROMElzgenetic
12111211
STAR_DROMESgenetic
10655223
AFF4_DROMElilligenetic
10655223
AFF4_DROMElilligenetic
11171404
EYA_DROMEeyagenetic
10655223
BUN1_DROMEbungenetic
7555710
BUN2_DROMEbungenetic
7555710
SOS_DROMESosgenetic
10655223
SUH_DROMESu(H)genetic
11937027
CADE_DROMEshggenetic
16014514
TAF4_DROMETaf4genetic
10655223
ELL_DROMESu(Tpl)genetic
10655223
PROS_DROMEprosgenetic
8804311
GLAS_DROMEglgenetic
10655223
PNT1_DROMEpntgenetic
10655223
PNT2_DROMEpntgenetic
10655223
PNT1_DROMEpntgenetic
11937027
PNT2_DROMEpntgenetic
11937027
MPIP_DROMEstggenetic
10655223
AXN_DROMEAxngenetic
21869817
PANG1_DROMEpangenetic
21869817
PANG2_DROMEpangenetic
21869817
PANG1_DROMEpangenetic
23444354
PANG2_DROMEpangenetic
23444354
SPEN_DROMEspengenetic
10655223
DRI_DROMEretngenetic
10655223
TTKB_DROMEttkgenetic
8643523
TTKA_DROMEttkgenetic
8643523
TTKB_DROMEttkgenetic
9383057
TTKA_DROMEttkgenetic
9383057
ERKA_DROMErlgenetic
10655223
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of POK_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543; SER-677; SER-682AND SER-696, AND MASS SPECTROMETRY.

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