| UniProt ID | TTKB_DROME | |
|---|---|---|
| UniProt AC | P17789 | |
| Protein Name | Protein tramtrack, beta isoform | |
| Gene Name | ttk | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 643 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Binds to a number of sites in the transcriptional regulatory region of ftz. [PubMed: 2104801 Isoform beta is required to repress inappropriate segmentation gene transcription and repress genes incompatible with development of photoreceptor cell fates] | |
| Protein Sequence | MKMASQRFCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHPIVILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATGSESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKLSGSSNGTGNDYDDFDRENMMNDSSDLGNGKMCNESYSGNDDGSDDNQPNAGHTDDLNESRDSLPSKRSKNSKDHRVVSHHEDNSTSDGNDSDGEGLDTSYMEPQLMLDEYDEPVEFKYNPLTDNSSPTQDHTDGSHLNEQARQQAFLIAAQRKHQVETAAAAAASGIKLNIIGMAAGGAQVKSMVSIPKLTPIGKVNAASTPLVSPAGSFSTATVKPRVQKRPKLGKQNGDVKPAVFSSQEYLDIYNSNDGFKLKAAGLSGSTPNLSAGLGTPSVKTKLNLSSNVGEGEAEGSVRDYCTKEGEHTYRCKVCSRVYTHISNFCRHYVTSHKRNVKVYPCPFCFKEFTRKDNMTAHVKIIHKIENPSTALATVAAANLAGQPLGVSGASTPPPPDLSGQNSNQSLPATSNALSTSSSSSTSSSSGSLGPLTTSAPPAPAAAAQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 123 | Ubiquitination | LTEVNDDKPSPAAAA CEECCCCCCCHHHHH | 50.70 | 18160715 | |
| 201 | Ubiquitination | RKRGRPRKLSGSSNG CCCCCCCCCCCCCCC | 50.08 | 18160715 | |
| 327 | Phosphorylation | YNPLTDNSSPTQDHT CCCCCCCCCCCCCCC | 40.27 | 19429919 | |
| 328 | Phosphorylation | NPLTDNSSPTQDHTD CCCCCCCCCCCCCCC | 37.92 | 22668510 | |
| 330 | Phosphorylation | LTDNSSPTQDHTDGS CCCCCCCCCCCCCCC | 48.88 | 19429919 | |
| 334 | Phosphorylation | SSPTQDHTDGSHLNE CCCCCCCCCCCHHCH | 50.80 | 19429919 | |
| 355 | Ubiquitination | FLIAAQRKHQVETAA HHHHHHHHHHHHHHH | 26.72 | 18160715 | |
| 397 | Ubiquitination | PKLTPIGKVNAASTP CCCCCCCCCCCCCCC | 32.79 | 18160715 | |
| 402 | Phosphorylation | IGKVNAASTPLVSPA CCCCCCCCCCCCCCC | 28.31 | 19429919 | |
| 403 | Phosphorylation | GKVNAASTPLVSPAG CCCCCCCCCCCCCCC | 18.86 | 19429919 | |
| 407 | Phosphorylation | AASTPLVSPAGSFST CCCCCCCCCCCCCCC | 19.40 | 19429919 | |
| 411 | Phosphorylation | PLVSPAGSFSTATVK CCCCCCCCCCCCCCC | 20.38 | 19429919 | |
| 413 | Phosphorylation | VSPAGSFSTATVKPR CCCCCCCCCCCCCCC | 20.87 | 19429919 | |
| 414 | Phosphorylation | SPAGSFSTATVKPRV CCCCCCCCCCCCCCH | 25.08 | 19429919 | |
| 416 | Phosphorylation | AGSFSTATVKPRVQK CCCCCCCCCCCCHHC | 29.20 | 19429919 | |
| 418 | Ubiquitination | SFSTATVKPRVQKRP CCCCCCCCCCHHCCC | 23.81 | 18160715 | |
| 440 | Phosphorylation | DVKPAVFSSQEYLDI CCCCCCCCCCHHHHH | 25.23 | 18327897 | |
| 441 | Phosphorylation | VKPAVFSSQEYLDIY CCCCCCCCCHHHHHC | 18.63 | 18327897 | |
| 457 | Ubiquitination | SNDGFKLKAAGLSGS CCCCEEEEECCCCCC | 36.46 | 18160715 | |
| 462 | Phosphorylation | KLKAAGLSGSTPNLS EEEECCCCCCCCCCC | 29.76 | 23607784 | |
| 464 | Phosphorylation | KAAGLSGSTPNLSAG EECCCCCCCCCCCCC | 37.00 | 23607784 | |
| 465 | Phosphorylation | AAGLSGSTPNLSAGL ECCCCCCCCCCCCCC | 21.52 | 23607784 | |
| 474 | Phosphorylation | NLSAGLGTPSVKTKL CCCCCCCCCCCCEEE | 19.89 | 21082442 | |
| 478 | Ubiquitination | GLGTPSVKTKLNLSS CCCCCCCCEEEECCC | 44.26 | 18160715 | |
| 480 | Ubiquitination | GTPSVKTKLNLSSNV CCCCCCEEEECCCCC | 29.66 | 18160715 | |
| 545 | Ubiquitination | YPCPFCFKEFTRKDN EECCCCCCCCCCCCC | 53.77 | 18160715 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TTKB_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TTKB_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TTKB_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| LOLAL_DROME | lolal | physical | 14605208 | |
| PP4C_DROME | Pp4-19C | physical | 14605208 | |
| STAT_DROME | Stat92E | physical | 14605208 | |
| DEI_DROME | tx | physical | 14605208 | |
| ARRA_DROME | Arr1 | physical | 14605208 | |
| JMJD4_DROME | CG7200 | physical | 14605208 | |
| KU70_DROME | Irbp | physical | 22036573 | |
| RFC1_DROME | Gnf1 | physical | 22036573 | |
| SINA_DROME | sina | physical | 12215542 | |
| PHYL_DROME | phyl | physical | 12215542 | |
| LOZEN_DROME | lz | genetic | 20003234 | |
| AFF4_DROME | lilli | genetic | 11171404 | |
| UBPE_DROME | Ubp64E | genetic | 18160715 | |
| CHDM_DROME | Mi-2 | genetic | 11743021 | |
| CTBP_DROME | CtBP | genetic | 10978285 | |
| MPIP_DROME | stg | genetic | 12447387 | |
| GIANT_DROME | gt | physical | 23935523 | |
| HANG_DROME | hang | physical | 25242320 | |
| PHYL_DROME | phyl | physical | 9267026 | |
| OTP_DROME | otp | physical | 25242320 | |
| DICH_DROME | D | physical | 23935523 | |
| TTKB_DROME | ttk | physical | 23847101 | |
| TTKA_DROME | ttk | physical | 23847101 | |
| TTKB_DROME | ttk | physical | 12204250 | |
| TTKA_DROME | ttk | physical | 12204250 | |
| TTKB_DROME | ttk | physical | 12384587 | |
| TTKA_DROME | ttk | physical | 12384587 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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