HANG_DROME - dbPTM
HANG_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HANG_DROME
UniProt AC Q9VXG1
Protein Name Zinc finger protein hangover
Gene Name hang
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1959
Subcellular Localization Nucleus .
Protein Description Required for normal development of ethanol tolerance. Relies on two distinct molecular pathways: a cellular stress pathway defined by hang, and a parallel pathway requiring octopamine..
Protein Sequence MCDAAAATATTTTTAAVAAAVATTTASVALEATATQPGTTTTTVATASAGTTSPEAAIPTAATATSARNSNSERSARQNCCRLCIAPQTECISIINSYAADKEPLSTKIHNCVGIKVTPQDRLSQQICHACISYLNSWQSFKNRCFSSQAKQRQWLDTNKSKLLNYLDLNSAENGGGGFFDQHLHQQQQHHQHLENELEAEKEKATPTAASTAANILDGIHSLKKRKSLTVYPLPAMPIKDEPIDTDDDYQMKSIDESDDMVDPTMFLERSEHEGDVPLTASDYDYTAQHGVNASSVAASLPPNAVANVAAAGDSKVASCRACSLQFSTRANARRHERNLHPNLFQLSTDSPHNTPITKPTPALAAALEMQRAAAAAATAEANRAAGAAGGNISTQKYRQVVMNAFIKCEGGGYDYDNPEQYRPLLTRDKVEFIEQNDEFLEQYQTMTCRCCNKYFSTYKNFMAHVRKKYPQLPRNLCFNCLKMNDSKALFISHLKKRNCINLFRVLNALRGKTTTVVVPIADDVADDGATGSIPVADAGAGVVAMNSPTVTASGEVVTPGGGSERPEKLRAKELLVNKLYECKLCPKGFRTKHEFRTHVYDKHADVQRKDNNSIQCSFCGLDFADPVDRRRHYNNMDCIVRLRCMTCDAKLETHQRFLDHVYQDHLGGVGGGAVSDNASTTGSGMARSNSMEHSPGKRSLLGALGVGSSAEESRSSSAAPPLTSTPKLAGGNQVGGGGSTSASAAAAAQSSANRDASAPKSQYFSRMPQVCPICGQQYNNYNNVLRHMESKHPNKLPETYKCVRCGLGYPRISYLREHMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGGTLDDEEEEPGSVAKKMRLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANRMTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRMRCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIKQFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLAAGGSTASAPLYWYQCKYCPSNFNTNKKLAIHINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQQQDGQLHSHHTAKRTIFRHKTGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAAAGTSLKIRIPEVACTICGARFTDQEHFSKHIQKHEQELYVDNPLAAMFDDGPADAGQFQVERQNENGEYACDLCAKTFPQVIALKVHRKWHFRGDSKQNPIDGEATQLTNNNHTTNNNNNNSMHLRELHAVGLMPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEVSNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLMNHINNHLKEEVIVPVATKAAIERTAAMESAAADANAAATLSALGEGAETEDQFAEKVEAAGATTTDKLTNPDEEDSDDLDEDSSGDDDDSSGTGDDDDDDDSDDDEDGEGEDEDEEGDGGEGEDEEGVQPPAQLLPQQQHKTDLNLNQDDDDLVEEVISSDDDEDDDGEVESDDDDEDDDDEEDDVEEPEPVGLTVRPLMNGKSKMPPLIVASSDDEDDGVMPIEDIIEEEFDEDADPDPEDAIEEVDEDDLDEGEVEDEPNVVSTASFSESESSTTTTSNSHSHSHSTGERRKKAVDQLNDPGFTCDLCQLCFDSQELLQSHIKSHILNGPKLSTVSAAAAAAAAAATASSKATALLTAAKAKPDSKSAVLANNNNSKTSSKTVAAGATN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
206PhosphorylationEAEKEKATPTAASTA
HHHHHHCCCCHHHHH		32.0419429919
208PhosphorylationEKEKATPTAASTAAN
HHHHCCCCHHHHHHH		30.4219429919
211PhosphorylationKATPTAASTAANILD
HCCCCHHHHHHHHHH		19.0019429919
212PhosphorylationATPTAASTAANILDG
CCCCHHHHHHHHHHH		25.6819429919
222PhosphorylationNILDGIHSLKKRKSL
HHHHHHHHCCCCCCC		39.7119429919
228PhosphorylationHSLKKRKSLTVYPLP
HHCCCCCCCEEEECC		33.0519429919
246PhosphorylationIKDEPIDTDDDYQMK
CCCCCCCCCCCCCCC		41.8919429919
258PhosphorylationQMKSIDESDDMVDPT
CCCCCCCCCCCCCHH		34.8522817900
680PhosphorylationGAVSDNASTTGSGMA
CCCCCCCCCCCCCCC		32.5318327897
689PhosphorylationTGSGMARSNSMEHSP
CCCCCCCCCCCCCCC		24.5825749252
695PhosphorylationRSNSMEHSPGKRSLL
CCCCCCCCCCCCHHH		23.2627626673
700PhosphorylationEHSPGKRSLLGALGV
CCCCCCCHHHHHHCC		31.2829892262
832PhosphorylationGVDKNRHSGGFEYIV
CCCCCCCCCCCEEEE		37.0619060867
890PhosphorylationGSVAKKMRLDDSSNN
CCCCHHEECCCCCCC		34.3322817900
891PhosphorylationSVAKKMRLDDSSNNS
CCCHHEECCCCCCCC		47.2022817900
894PhosphorylationKKMRLDDSSNNSSLV
HHEECCCCCCCCCEE		29.3322817900
895PhosphorylationKMRLDDSSNNSSLVG
HEECCCCCCCCCEEH		29.2422817900
898PhosphorylationLDDSSNNSSLVGVAS
CCCCCCCCCEEHHHC		17.9918327897
899PhosphorylationDDSSNNSSLVGVASQ
CCCCCCCCEEHHHCC		3.4518327897
1265PhosphorylationHTAKRTIFRHKTGDD
HHHCCEEECCCCCCC		39.45-
1269PhosphorylationRTIFRHKTGDDDDEE
CEEECCCCCCCCCCC		70.7119429919
1950PhosphorylationNNNSKTSSKTVAAGA
CCCCCCCCCCCCCCC		27794539
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HANG_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HANG_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HANG_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDE4B_DROMEdncphysical
28076795
PDE4E_DROMEdncphysical
28076795
PDE4C_DROMEdncphysical
28076795
PDE4A_DROMEdncphysical
28076795
G6PD_DROMEZwphysical
28076795
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HANG_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228; THR-246; SER-680;SER-832; SER-890; SER-891; SER-894 AND SER-895, AND MASS SPECTROMETRY.

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