PDE4A_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE4A_DROME
• UniProt AC: Q9W4T4
• Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I
• Gene Name: dnc {ECO:0000312|EMBL:AAF45858.3}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1209
• Protein Description: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory..
• Protein Sequence: MMRLARFTQGFSFNKNVAKHRGSGSSNGTGNGSGTGNGQGLGGSCSANGLAATGGVGGGGGSGSGGGGCGSGSGSGSGKRKSKARTKCFGGTVFRCCLPCRGGGSAAPATSPPQTPAQTPDELKVIPEDCNLEKSAEQKRDLLERNNKEDDLLNRTVSGSELDLYGGAGGGTKKHSLADTIDTSVTTPISLKTLINDVDEELDQQLSAADIAAASLASGLVARRAEPETLSDASVSPTAVVQQQQQQQQQLQQPLLQSQPHFVPSSGNILSQVTLYSGSNPSTNPCQSAVQNQGQNSNPNPNQNPNTNPNQNQQRCSCQPQTSPLPHIKEEEESDQANFKHQTSLKEHQPLPPPITIATGYCGSCESVHHSSATSSSAGTVPPGGQQTQEYIAGTSSTPSPRIKLKFRKPHKSCWSRIVLAPIGSAGGSSSATTVIGSNSNETLASSSTTGGTATTTQNSSSVSVAAHHRLTSSSASALATSHPSNSQLLPTSKMQAEQGSIGDLQKYHSRYLKNRRHTLANVRFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
187	Phosphorylation	TIDTSVTTPISLKTL CCCCCCCCCCCHHHH	19.23	27794539
190	Phosphorylation	TSVTTPISLKTLIND CCCCCCCCHHHHHHC	25.64	27794539
535	Phosphorylation	ENGQGARSPLEGGSP ECCCCCCCCCCCCCC	33.05	19429919
541	Phosphorylation	RSPLEGGSPSAGLVL CCCCCCCCCCHHHHC	26.91	29892262
543	Phosphorylation	PLEGGSPSAGLVLQN CCCCCCCCHHHHCCC	36.34	29892262
557	Phosphorylation	NLPQRRESFLYRSDS CCCCHHHHHHHCCCC	20.81	19429919
560	Phosphorylation	QRRESFLYRSDSDFE CHHHHHHHCCCCCCC	13.17	19429919
562	Phosphorylation	RESFLYRSDSDFEMS HHHHHHCCCCCCCCC	28.10	19429919
564	Phosphorylation	SFLYRSDSDFEMSPK HHHHCCCCCCCCCHH	45.50	19429919
569	Phosphorylation	SDSDFEMSPKSMSRN CCCCCCCCHHHHCCC	23.21	19429919
706	Phosphorylation	NKELSHFSESSRSGN HHHHHHHCCCCCCCC	31.01	19429919
708	Phosphorylation	ELSHFSESSRSGNQI HHHHHCCCCCCCCHH	29.83	19429919
709	Phosphorylation	LSHFSESSRSGNQIS HHHHCCCCCCCCHHH	26.81	19429919
780	Phosphorylation	SGVKRPLSHTNSFTG CCCCCCCCCCCCCCC	30.83	19429919
782	Phosphorylation	VKRPLSHTNSFTGER CCCCCCCCCCCCCCC	29.22	19429919
784	Phosphorylation	RPLSHTNSFTGERLP CCCCCCCCCCCCCCC	25.91	19429919
786	Phosphorylation	LSHTNSFTGERLPTF CCCCCCCCCCCCCCC	37.64	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDE4A_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE4A_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE4A_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CYA1_DROME	rut	genetic	23197709
CYA1_DROME	rut	genetic	1371316
AMN_DROME	amn	genetic	7754370
FMR1_DROME	Fmr1	genetic	25568131
GNAS_DROME	Galphas	genetic	15063169
GPRK2_DROME	Gprk2	genetic	11319866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.