GNAS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GNAS_DROME
• UniProt AC: P20354
• Protein Name: G protein alpha s subunit
• Gene Name: Galphas
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 385
• Protein Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase (By similarity)..
• Protein Sequence: MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-palmitoylation	------MGCFGSPTS ------CCCCCCCCC	18.56	-
3	S-palmitoylation	-----MGCFGSPTSK -----CCCCCCCCCC	3.18	-
16	Phosphorylation	SKQSDVNSEDSKSQK CCCCCCCCCCCHHHH	42.50	27626673
26	Phosphorylation	SKSQKRRSDAISRQL CHHHHHHHHHHHHHH	35.11	22817900
316 (in isoform 2)	Phosphorylation	-	3.61	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GNAS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GNAS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GNAS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATD1_DROME	Vha36-1	physical	14605208
PDE4B_DROME	dnc	genetic	21145008
PDE4E_DROME	dnc	genetic	21145008
PDE4C_DROME	dnc	genetic	21145008
PDE4A_DROME	dnc	genetic	21145008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.