PDE4B_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDE4B_DROME
• UniProt AC: P12252
• Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase
• Gene Name: dnc
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1070
• Protein Description: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Vital for female fertility. Required for learning/memory..
• Protein Sequence: MSQESNGGPAAGGGAAAAPPPPPQYIITTPSEVDPDEVRSMADLELGSPEKQVQVQSQKFSSTSSTTKVATHSFSMSSSAGTTGQQSKQDSAQQIQQLQQLQQLQQLQQQQQQQQSQRIISSSTRSQSLQSSTIVGEATTITSGAAQILSASAAASLAQQLKAQSSTSIITSSEQRTSTSTSSSSSTRYIASGSSNLAGGNSNSASSASSKTRFQSFLQQPEGAHGFLTAHQKHVRQFVRSTSAHSEAAAGVAGARAEKCIRSASTQIDDASVAGVVESAGNLTDSSATGGSMQLSMSKLGLQQSSSILISKSAETIEMKSSSAGMRTQLTLSGGFLAPPGNRKITILSPIHAPPGLHDMLKRAQGRSPLSPRISFPGSDSDLFGFDVENGQGARSPLEGGSPSAGLVLQNLPQRRESFLYRSDSDFEMSPKSMSRNSSIASERFKEQEASILVDRSHGEDLIVTPFAQILASLRSVRNNLLSLTNVPASNKSRRPNQSSSASRSGNPPGAPLSQGEEAYTRLATDTIEELDWCLDQLETIQTHRSVSDMASLKFKRMLNKELSHFSESSRSGNQISEYICSTFLDKQQEFDLPSLRVEDNPELVAANAAAGQQSAGQYARSRSPRGPPMSQISGVKRPLSHTNSFTGERLPTFGVETPRENELGTLLGELDTWGIQIFSIGEFSVNRPLTCVAYTIFQSRELLTSLMIPPKTFLNFMSTLEDHYVKDNPFHNSLHAADVTQSTNVLLNTPALEGVFTPLEVGGALFAACIHDVDHPGLTNQFLVNSSSELALMYNDESVLENHHLAVAFKLLQNQGCDIFCNMQKKQRQTLRKMVIDIVLSTDMSKHMSLLADLKTMVETKKVAGSGVLLLDNYTDRIQVLENLVHCADLSNPTKPLPLYKRWVALLMEEFFLQGDKERESGMDISPMCDRHNATIEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEENRDYYQSMIPPSPPPSGVDENPQEDRIRFQVTLEESDQENLAELEEGDESGGESTTTGTTGTTAASALSGAGGGGGGGGGMAPRTGGCQNQPQHGGM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	Phosphorylation	MADLELGSPEKQVQV HHHHCCCCHHHHHEE	42.37	19429919
48 (in isoform 4)	Phosphorylation	-	42.37	19429919
48 (in isoform 5)	Phosphorylation	-	42.37	19429919
241 (in isoform 5)	Phosphorylation	-	22.78	19429919
241	Phosphorylation	HVRQFVRSTSAHSEA HHHHHHHHCCCCHHH	22.78	19429919
241 (in isoform 4)	Phosphorylation	-	22.78	19429919
242 (in isoform 5)	Phosphorylation	-	21.26	19429919
242 (in isoform 4)	Phosphorylation	-	21.26	19429919
242	Phosphorylation	VRQFVRSTSAHSEAA HHHHHHHCCCCHHHH	21.26	19429919
243 (in isoform 4)	Phosphorylation	-	25.82	19429919
243 (in isoform 5)	Phosphorylation	-	25.82	19429919
243	Phosphorylation	RQFVRSTSAHSEAAA HHHHHHCCCCHHHHH	25.82	19429919
246 (in isoform 4)	Phosphorylation	-	28.75	19429919
246 (in isoform 5)	Phosphorylation	-	28.75	19429919
246	Phosphorylation	VRSTSAHSEAAAGVA HHHCCCCHHHHHHHH	28.75	19429919
346	Phosphorylation	PPGNRKITILSPIHA CCCCCEEEEEECCCC	20.92	19429919
346 (in isoform 4)	Phosphorylation	-	20.92	19429919
346 (in isoform 5)	Phosphorylation	-	20.92	19429919
349	Phosphorylation	NRKITILSPIHAPPG CCEEEEEECCCCCCC	20.25	19429919
349 (in isoform 5)	Phosphorylation	-	20.25	19429919
349 (in isoform 4)	Phosphorylation	-	20.25	19429919
368 (in isoform 4)	Phosphorylation	-	36.70	19429919
368 (in isoform 5)	Phosphorylation	-	36.70	19429919
368	Phosphorylation	LKRAQGRSPLSPRIS HHHHCCCCCCCCCEE	36.70	19429919
371 (in isoform 4)	Phosphorylation	-	18.60	19429919
371 (in isoform 5)	Phosphorylation	-	18.60	19429919
371	Phosphorylation	AQGRSPLSPRISFPG HCCCCCCCCCEECCC	18.60	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDE4B_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDE4B_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDE4B_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CYA1_DROME	rut	genetic	23197709
CYA1_DROME	rut	genetic	1371316
AMN_DROME	amn	genetic	7754370
FMR1_DROME	Fmr1	genetic	25568131
GNAS_DROME	Galphas	genetic	15063169
GPRK2_DROME	Gprk2	genetic	11319866

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.