| UniProt ID | CYA1_DROME | |
|---|---|---|
| UniProt AC | P32870 | |
| Protein Name | Ca(2+)/calmodulin-responsive adenylate cyclase | |
| Gene Name | rut | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 2248 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein. |
|
| Protein Description | This is a membrane-bound, calmodulin-sensitive adenylyl cyclase. Inactivation of this cyclase leads to a learning and memory defect.. | |
| Protein Sequence | MDHAVKATRGRPLNTLRFENDELECLYQRYTLKLQRFSVLGVVALVFVLCGVMAALSLTFNNAATFHNIFNAIVCGLFAVVLVLLQCSVIKDHHLPTLCYGILLFTASICVVSMPTLGSVFPVDTKEVMAEGVWQIVFVVFLAYAMMPLQIWEAVAFGIALPSVHISLTVYKIFTDALRYLEYNQLIANIVIFIGVNVAGLVVNIMMERAQRRTFLDTRNCIASRLEIQDENEKLERLLLSVLPQHVAMQMKNDILSPVAGQFHRIYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCVSGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSNDVTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSSYLRDHGVDTFFIVPPPHRRKPLMLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGGGGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISGGGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHHQPTNRVNRFLSQAINARSVDCDKSEHVDRLTLRFRQSDMEREYHKDFDLGFTTAMGCSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLAVRLKWIIWDISESFSLRMAITIFTVILIYSVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLPQYVSLSAAFAFLSVSVFLRLPIIFKSLLVLGMGTIYGLFIELSHQNIFECYDNRVNASIPLHLISLARIAIFMIAILVHGRLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLLPAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFDELLKEDRFRGIDKIKTVGSTYMAVVGLIPEYKIQPNDPNSVRRHMTALIEYVKAMRHSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVTQEVVDSLVGSHFEFRCRGTIKVKGKGDMVTYFLCDSGNKSLNGEVRNAMSLPQSLHAPDYYMKVSQFPENRVNTDTYSKKENGHLYAGNGVEEQQLLLQHQHKQHDPLPLPAPPPPVHHHLHQQQQQRLNSKLQKQPIFMANGGLPNIRENGNGHNGEHQQQQQQQQQHQQQQQQQQQHGGFMVATTTPPAAVAVPLQPQHHQLQFQHPHQHPLPSAVSVPVQHQILLHHQLQLQHQPVPSVMLREFNIIENPTSGGRHQQMEQLPPHHGSLDLSGMGMGVGAGVLGSDCFMMPRRDRERTYVPPLNQHGHHPPHHLHSNLNLNQSQHPPSFTSLGYGQCRESEPLLHASSVAPVAKIMPMQHAPKYEPPRYTSPHTMLSQQHQQQQQQQHQHQQPQSQSAQDQQTHPAQDPHPLQRQYAMYSQQPQLPPKPVLRTYMKPLPKLPTDLEESRDMSSTDDLSSRPHSPSMSSSDESYSKTTEGEGEGDEDSPRMVNGGHLHHRNGYHLPAGGLVNPLQWLYPCDIQVDPTSPVVDMAHLHDFELSSTTESQGHHTNSNTTSNTQHKGDSCNSFDFQKAAVGTAAGAAIATKSPFERELQRLLNESSRARCLATATTTAGAISTTDQTASNGSRELSYSLSNGKLSSANGHGVGGSGSGSGSGSGSGSAVGNGSGGSGSSNGNLSGGSGSNSNSGNNNSSHHKTEQQQNMDHEHLAGGKLLGSNSFMIAKHPVGLEAIKEITRNKNPSESSQMQTSDTESCEILHENRNQMHVLAMLEMHTAKELNGSHAHHGQHHQQPQRTHRQRPRSKELQYSHESLDGLDGAVQSQSQQRHQRYHHHHHHQQRQQQQQRYNHVQEQEERDDTEDNLADEEFEDDEVGRDVRQKRLQKSELNHKRSEVATEAGNHHDDEVEEEDDDDDEEEDHRNGGREAAPLTNGSMRGLEANVINDELKYGATHLNHQSMDSNPLESQSEWSDDDCREEATGGAESTGYITDEPGLENISLLNEAGLTDAEGALSDVNSLYNAPDVDDTSVSSRASSRLLSLDSLSGLYDCDLDSKHELAIVNASHKISSKFGQPLSPAQQQHQQQQQQQQQQQQQHHQQQLQQNPQHTQAQSHLAPVQFQSAEELRE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 800 | N-linked_Glycosylation | SDHPCSGNGTTSFQN ECCCCCCCCCCCCCC | 28.48 | - | |
| 807 | N-linked_Glycosylation | NGTTSFQNDSHRKCS CCCCCCCCCCCCCCC | 51.22 | - | |
| 926 | Phosphorylation | EMDVLQESNKRILHN HHHHHHHHHHHHHHH | 34.39 | 25749252 | |
| 1168 | Phosphorylation | GEVRNAMSLPQSLHA HHHHHHHCCCHHHCC | 34.19 | 22668510 | |
| 1608 | Phosphorylation | EGEGDEDSPRMVNGG CCCCCCCCCCEECCC | 16.62 | 25749252 | |
| 1723 | Phosphorylation | QRLLNESSRARCLAT HHHHCHHHHHHHHHH | 24.63 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CYA1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CYA1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CYA1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PDE4B_DROME | dnc | genetic | 23197709 | |
| PDE4E_DROME | dnc | genetic | 23197709 | |
| PDE4C_DROME | dnc | genetic | 23197709 | |
| PDE4A_DROME | dnc | genetic | 23197709 | |
| AMN_DROME | amn | genetic | 9635429 | |
| 60A_DROME | gbb | genetic | 15295025 | |
| RAC1_DROME | Rac1 | genetic | 20178749 | |
| NMDA1_DROME | Nmdar1 | genetic | 20015341 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
