KU70_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KU70_DROME
• UniProt AC: Q23976
• Protein Name: ATP-dependent DNA helicase 2 subunit 1
• Gene Name: Irbp
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 631
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair (By similarity). Sequence-specific DNA-binding protein that has a high affinity for a 31 bp sequence in the Yp1 gene. Site-specific DNA binding to 31 bp P element inverted repeats..
• Protein Sequence: MSTWNPENDVDLLSGSEDEEDVSMKRDYHGREAILFVVDANLQTAGVERLLEALNIIRTAFISGLLVNDKDLIGLIFANTKHSPPPLEASALDNIVMPDNCAVFLPLRQLTKPIVEHYLEFMGGVETQFADVYGLAEPDGRGRFDLMIRLCIEMLEKCGKKLNNAKIAYVTDVREPHPSNSNHFQAALQKASDLEGKEFEFHVIPMVDDFDYEPFYKEFITLSRAIELDAFQVPDAQMLREILSDRKLKQDFLRRCLGHFSFYLGPNLSMSVQYYNYFQRRAYPRKVQILRRDNSVVRTKRVITVQKQKDDGSQDIEHEYQIKVTGGWYTCNVGERDLRISMDQLNRVRNLHKPQMMLLGFKHRSSLPEVSYIKPANFMYPDDQSIIGSKRLFRALWERCLVRDKIAICLFMCKRKSIPRYVALVPVEAPDNGEDKNYRSLLCGDGFKIVYLPEAKHIRHLDLQDWNNTENTADEQKVEFFQKIIKKLRVDYQPNLINDPSLDALQANLLALSLDFSTDTKGLDNLLDTSQQDKRIEKLLPDYEMFAPEAEPHKKRAAKSTTAGASGPKMAKIDDDQLKEFEFVKSLNKDEALTSCTAAQLHFILQHHFDVTMPKSSKKAKLVAKIEELHK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	ENDVDLLSGSEDEED CCCCCCCCCCCCHHH	47.79	19429919
16	Phosphorylation	DVDLLSGSEDEEDVS CCCCCCCCCCHHHHH	38.20	19429919
23	Phosphorylation	SEDEEDVSMKRDYHG CCCHHHHHHCCCCCC	30.79	19429919
313	Phosphorylation	QKQKDDGSQDIEHEY EEECCCCCCCCEEEE	31.51	19429919
341	Phosphorylation	GERDLRISMDQLNRV CCCEEECCHHHHHHH	15.18	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KU70_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KU70_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KU70_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FRY_DROME	fry	physical	15575970
PAN3_DROME	CG11486	physical	15710747
CXXC1_DROME	Cfp1	physical	15710747
ELF1_DROME	grh	physical	15710747
RG190_DROME	RhoGAPp190	physical	15710747
RFC2_DROME	RfC4	physical	22036573
OTP_DROME	otp	physical	25242320

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.