dbPTM

CXXC1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CXXC1_DROME
UniProt AC	Q9W352
Protein Name	CXXC-type zinc finger protein 1
Gene Name	Cfp1
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	663
Subcellular Localization	Nucleus .
Protein Description	Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3. Essential for Set1 association with chromatin and trimethylation of histone H3 at 'Lys-4' at transcription puffs. Additionally, is critical for general chromosomal association of Set1..
Protein Sequence	MTDKRKYKKTVSFTRCTAIIFLTTKEVSKQKEEIRREIAREFDLPERKSKIATILKQEDQAYCICRSSDCSRFMIGCDGCEEWYHGDCIGITEKEAKHIKQYYCRRCKKENPELQTIFRLVATERAAASNAASTSLNAPGVGPSGAAPAAAPVASATTSQQAPPPTTAAAKRKNSSAREPKMGKRCGTCEGCRRPNCNQCDACRVRVGHKPRCIFRTCVVQAATVLKESQATQAGPSRKREKAAPKSRNVQVGPRAASPEIFLNPELQGIRQCYGPNCCSHARPQSKYCSDKCGFNLATKRIFQVLPQRLQEWNLTPSRAAEETRKHLDNIRHKQSLVRFALAELEKRSEELNMVVERAKRSSIDTLGSQDTADMEDEQSMYCITCGHEIHSRTAIKHMEKCFNKYESQASFGSIFKTRMEGNNMFCDFYNPASKTYCKRLRVLCPEHSKDPKVNDTDVCGSPLVNNVFNPTGEFCRAPKKNCFKHYAWEKIRRAEIDLERVRQWLKMDDLMEQERVMRQQLTSRANLLGLMLHSTYNHEVMDELVRKQQEHLVEFEKQRRRLAHQQQIQTQQKQYQEKQKLMLQQQQQQQQQQQQQQQQQQQQQLQQPQQQQQQQQQQQQEQQQLQLKPHHLQQLQLQLLQQQQKKAQIPQKTQIIYLQKKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
258	Phosphorylation	QVGPRAASPEIFLNP CCCCCCCCCCHHCCH		25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CXXC1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CXXC1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CXXC1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMIN_DROME	inv	physical	14605208
KELC_DROME	kel	physical	14605208
TFP11_DROME	sip1	physical	14605208

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CXXC1_DROME

Related Literatures of Post-Translational Modification