TFP11_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFP11_DROME
• UniProt AC: Q9Y103
• Protein Name: Septin-interacting protein 1
• Gene Name: sip1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 839
• Subcellular Localization: Nucleus.
• Protein Description: May be involved in pre-mRNA splicing..
• Protein Sequence: MSDNDYERFEITDYDLDNEFNINRPRGRQSRHQQIYGIWADDSEEESGGEGGTKRRGRAARKPKDYTMPVNFVAGGIQQAGKKKKKALQADDEKGSQKEGAEADQGEESDDSAASGRPAFGQNDPGSSNSSSEEERPTLSRKQPSTTFQHRSHIASERNVGAWEQHTRGIGAKLLLQMGYEPGKGLGKDLQGISHPVQAHVRKGRGAIGAYGPETAASIGGKTNKSIKVDEDVREAKEFKDQLNKWRKGSAGGAEPMERQGKRYYYKSVEEVIAKGHTSGHLLSEKLSKKLGNVRVIDMTGPEKRVLSGYHALGQAKITPEETLYDTEATEKGSAPACVFAMPELTHNLQLLVSQCEQQIIAIDNQERECSSQQAALESEHRKLEEIVQLERNHIRTLEESLERVERLIDNPDLSLPQAERLFRELLVDYAAEFHEFGLADLAAGVIAPLLKRELVQWQPLENPTEPLPLIKKWRGMLQQGDAAEQQPRNVFDPYSSLIWAGVMPSFRSSAAAWQPKEHPPMASLLDAWAPLLPSWVLDSVLEQLVLPRLVAGVQEWDPLTDTVPIDSWVLPWHAILGSKLEEAVYPQIRSKLGIALRAWSPHDRSARAMLTPWQKAFPEEEMQEFLQRYIVPKLQATLGELIINPMHQDLELWQQVWEWHELIDPMYMAQLLDRHFFPRWMQVLVVWLNQSPDYAEISRWYTGWKSMLSEPLLREPSVKEHLRRALEIMHRASDTLLQPTVTPTPPPPVPPAPVIMMDLIHPPAQLEFKELVSQQCADLGIIFAPLPGRREMGKQIYRVGKLFCYIDRHVCMVSDGSFSNWKPVSLNHLLERSQTGIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	QSRHQQIYGIWADDS CCCCCEEEEEECCCC	9.75	25749252
43	Phosphorylation	YGIWADDSEEESGGE EEEECCCCCCCCCCC	47.67	19429919
47	Phosphorylation	ADDSEEESGGEGGTK CCCCCCCCCCCCCCC	56.21	19429919
53	Phosphorylation	ESGGEGGTKRRGRAA CCCCCCCCCCCCCCC	32.03	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFP11_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFP11_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFP11_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-47 AND THR-53,AND MASS SPECTROMETRY.
PubMed: 18327897