| UniProt ID | ELF1_DROME | |
|---|---|---|
| UniProt AC | P13002 | |
| Protein Name | Protein grainyhead | |
| Gene Name | grh | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 1333 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Binds a CNS-specific regulatory element of the Dopa decarboxylase (Ddc) gene. Also interacts with sequences adjacent to other transcription units, including Ultrabithorax (Ubx) and engrailed (en). Activity in vivo may be required only at high levels transiently to activate the expression of Ddc in the CNS.. | |
| Protein Sequence | MSTSTATTSVITSNELSLSGHAHGHGHAHQLHQHTHSRLGVGVGVGILSDASLSPIQQGSGGHSGGGNTNSSPLAPNGVPLLTTMHRSPDSPQPELATMTNVNVLDLHTDNSKLYDKEAVFIYETPKVVMPADGGGGNNSDEGHAIDARIAAQMGNQAQQQQQQQQQTEHQPLAKIEFDENQIIRVVGPNGEQQQIISREIINGEHHILSRNEAGEHILTRIVSDPSKLMPNDNAVATAMYNQAQKMNNDHGQAVYQTSPLPLDASVLHYSGGNDSNVIKTEADIYEDHKKHAAAAAAAAGGGSIIYTTSDPNGVNVKQLPHLTVPQKLDPDLYQADKHIDLIYNDGSKTVIYSTTDQKSLEIYSGGDIGSLVSDGQVVVQAGLPYATTTGAGGQPVYIVADGALPAGVEEHLQSGKLNGQTTPIDVSGLSQNEIQGFLLGSHPSSSATVSTTGVVSTTTISHHQQQQQQQQQQQQQQQQQHQQQQQHPGDIVSAAGVGSTGSIVSSAAQQQQQQQLISIKREPEDLRKDPKNGNIAGAATANGPGSVITQKILHVDAPTASEADRPSTPSSSINSTENTESDSQSVSGSESGSPGARTTATLEMYATTGGTQIYLQTSHPSTASGAGGGAGPAGAAGGGGVSMQAQSPSPGPYITANDYGMYTASRLPPGPPPTSTTTFIAEPSYYREYFAPDGQGGYVPASTRSLYGDVDVSVSQPGGVVTYEGRFAGSVPPPATTTVLTSVHHHQQQQQQQQQHQQQQQQQQHHQQQQHHSQDGKSNGGATPLYAKAITAAGLTVDLPSPDSGIGTDAITPRDQTNIQQSFDYTELCQPGTLIDANGSIPVSVNSIQQRTAVHGSQNSPTTSLVDTSTNGSTRSRPWHDFGRQNDADKIQIPKIFTNVGFRYHLESPISSSQRREDDRITYINKGQFYGITLEYVHDAEKPIKNTTVKSVIMLMFREEKSPEDEIKAWQFWHSRQHSVKQRILDADTKNSVGLVGCIEEVSHNAIAVYWNPLESSAKINIAVQCLSTDFSSQKGVKGLPLHVQIDTFEDPRDTAVFHRGYCQIKVFCDKGAERKTRDEERRAAKRKMTATGRKKLDELYHPVTDRSEFYGMQDFAKPPVLFSPAEDMEKVGQLGIGAATGMTFNPLSNGNSNSNSHSSLQSFYGHETDSPDLKGASPFLLHGQKVATPTLKFHNHFPPDMQTDKKDHILDQNMLTSTPLTDFGPPMKRGRMTPPTSERVMLYVRQENEEVYTPLHVVPPTTIGLLNAIENKYKISTTSINNIYRTNKKGITAKIDDDMISFYCNEDIFLLEVQQIEDDLYDVTLTELPNQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 537 (in isoform 5) | Phosphorylation | - | 12.93 | 27794539 | |
| 871 (in isoform 2) | Phosphorylation | - | 45.77 | 27794539 | |
| 1141 (in isoform 3) | Phosphorylation | - | 10.24 | 27794539 | |
| 1179 | Phosphorylation | SPDLKGASPFLLHGQ CCCCCCCCCCEECCE | 25.50 | 18327897 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ELF1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ELF1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ELF1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| STAN_DROME | stan | genetic | 14706698 | |
| FRIZ_DROME | fz | genetic | 14706698 | |
| ELF1_DROME | grh | physical | 20599892 | |
| TAF2_DROME | Taf2 | physical | 7923382 | |
| TAF6_DROME | Taf6 | physical | 7923382 | |
| JHD1_DROME | Kdm2 | physical | 25242320 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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