dbPTM

TAF2_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TAF2_DROME
UniProt AC	Q24325
Protein Name	Transcription initiation factor TFIID subunit 2
Gene Name	Taf2
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1221
Subcellular Localization	Nucleus.
Protein Description	TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. An essential subunit binds to core promoter DNA..
Protein Sequence	METQPEVPEVPLRPFKLAHQVVSLTGISFERRSIIGVVELTIVPNSENLRLIRLNAKQLRIYSVVLNDVCQADFTYFDPFQNICYKEHKSRALEVYSKHHLTAAQYTDPDVNNGELLIQVPPEGYSMIQEGQGLRIRIEFSLENPKCGVHFVIPPASTDEETQMNSSHMFTNCYENSSRLWFPCVDSFADPCTWRLEFTVDKNMTAVSCGELLEVIMTPDLRKKTFHYSVSTPVCAPNIALAVGQFEIYVDPHMHEVTHFCLPGLLPLLKNTVRYLHEAFEFYEETLSTRYPFSCYKQVFVDELDTDISAYATMSIASVNLLHSIAIIDQTYISRTFMSRAVAEQFFGCFITSHHWSDTWLAKGIAEYLCGLYSRKCFGNNEYRAWVQSELARVVRYEEQYGGIILDCSQPPAPLPVSGTNQSAASSKQQEIVHYFPIKSLHTVSPKYVEAMRRKAHFVIRMLENRIGQELLIQVFNKQLALASSAATTKIGAGLWSQLLISTNIFIKAIFTVTGKDMSVFMDQWVRTGGHAKFSLTSVFNRKRNTIELEIRQDYVNQRGIRKYNGPLMVQLQELDGTFKHTLQIESTLVKSDITCHSKSRRNKKKKIPLCTGEEVDMDLSAMDDSPVLWIRLDPEMILLRDLIIEQPDFQWQYQLRHERDVTAQFQAIQALQKYPTNATRLALTDTIESERCFYQVRCEAAHSLTKVANQMVASWSGPPAMLNIFRKFFGSFSAPHIIKLNNFSNFQLYFLQKAIPVAMAGLRTSHGICPPEVMRFLFDLFKYNENSRNHYTDAYYRAALVEALGETLTPVVSVAIHGTQITTDSLSTDAKLVLDEVTRLLNMEKHLPSYKYMVSVSCLKVIRKLQKFGHLPSLPHIYRSYAEYGIYLDLRIAAMECLVDFVKVDGRSEDLEHLITLLETDPDPAARHALAQLLIDNPPFTRESRSRLDKPNLVDRLWFSINRLPYDTKLRCDIVDLYYALYGTKRPNCLQAGENQSFYKDLMKDNNSSVGSVTGSFKKTSDSKSHLPTPTNTLDNEPQERQKPAMVTIKRTATEAFEVGDEIIKLERSEEITVLDEPVNVQAYDSETKVNALQADEEARDTHQAAKRLKNEMYAEDDNSSTMLDVGDSTRYESSHEEGKLKSGDGGLKKKKKKEKKKHKHKHKHRHSKDKDKDKDKERKDKDKRDPHISRLQARETATPDTLSSEDSSNSNSLPPMNLN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
1135	Phosphorylation	GDSTRYESSHEEGKL CCCCCCCCCCCCCCC	28.23	19429919
1136	Phosphorylation	DSTRYESSHEEGKLK CCCCCCCCCCCCCCC	23.99	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TAF2_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TAF2_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TAF2_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAF11_DROME	Taf11	physical	8276241
TAF6_DROME	Taf6	physical	8178153
TAF1_DROME	Taf1	physical	8178153
TAF5_DROME	Taf5	physical	8178153

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TAF2_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1135 AND SER-1136, ANDMASS SPECTROMETRY.	18327897 [Abstract]