TAF1_DROME - dbPTM
TAF1_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TAF1_DROME
UniProt AC P51123
Protein Name Transcription initiation factor TFIID subunit 1
Gene Name Taf1
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 2129
Subcellular Localization Nucleus.
Protein Description TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Largest component and core scaffold of the complex. Contains N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Negative regulator of the TATA box-binding activity of Tbp..
Protein Sequence MEMESDNSDDEGSIGNGLDLTGILFGNIDSEGRLLQDDDGEGRGGTGFDAELRENIGSLSKLGLDSMLLEVIDLKEAEPPSDDEEEEDARPSAVSASEGMSAFDALKAGVKREDGAVKAQDDAIDYSDITELSEDCPRTPPEETSTYDDLEDAIPASKVEAKLTKDDKELMPPPSAPMRSGSGGGIEEPAKSNDASSPSDDSKSTDSKDADRKLDTPLADILPSKYQNVDVRELFPDFRPQKVLRFSRLFGPGKPTSLPQIWRHVRKRRRKRNQSRDQKTTNTGGSDSPSDTEEPRKRGFSLHYAAEPTPAECMSDDEDKLLGDFNSEDVRPEGPDNGENSDQKPKVADWRFGPAQIWYDMLEVPDSGEGFNYGFKTKAASTSSQPQLKDERRVKSPEDDVEDPSIADDAFLMVSQLHWEDDVVWDGNDIKAKVLQKLNSKTNAAGWLPSSGSRTAGAFSQPGKPSMPVGSGSSKQGSGASSKKAQQNAQAKPAEAPDDTWYSLFPVENEELIYYKWEDEVIWDAQQVSKVPKPKVLTLDPNDENIILGIPDDIDPSKINKSTGPPPKIKIPHPHVKKSKILLGKAGVINVLAEDTPPPPPKSPDRDPFNISNDTYYTPKTEPTLRLKVGGNLIQHSTPVVELRAPFVPTHMGPMKLRAFHRPPLKKYSHGPMAQSIPHPVFPLLKTIAKKAKQREVERIASGGGDVFFMRNPEDLSGRDGDIVLAEFCEEHPPLINQVGMCSKIKNYYKRKAEKDSGPQDFVYGEVAFAHTSPFLGILHPGQCIQAIENNMYRAPIYPHKMAHNDFLVIRTRNNYWIRSVNSIYTVGQECPLYEVPGPNSKRANNFTRDFLQVFIYRLFWKSRDNPRRIRMDDIKQAFPAHSESSIRKRLKQCADFKRTGMDSNWWVIKPEFRLPSEEEIRAMVSPEQCCAYFSMIAAEQRLKDAGYGEKFLFAPQEDDDEEAQLKLDDEVKVAPWNTTRAYIQAMRGKCLLQLSGPADPTGCGEGFSYVRVPNKPTQTKEEQESQPKRSVTGTDADLRRLPLQRAKELLRQFKVPEEEIKKLSRWEVIDVVRTLSTEKAKAGEEGMDKFSRGNRFSIAEHQERYKEECQRIFDLQNRVLASSEVLSTDEAESSASEESDLEELGKNLENMLSNKKTSTQLSREREELERQELLRQLDEEHGGPSGSGGAKGAKGKDDPGQQMLATNNQGRILRITRTFRGNDGKEYTRVETVRRQPVIDAYIKIRTTKDEQFIKQFATLDEQQKEEMKREKRRIQEQLRRIKRNQERERLAQLAQNQKLQPGGMPTSLGDPKSSGGHSHKERDSGYKEVSPSRKKFKLKPDLKLKCGACGQVGHMRTNKACPLYSGMQSSLSQSNPSLADDFDEQSEKEMTMDDDDLVNVDGTKVTLSSKILKRHGGDDGKRRSGSSSGFTLKVPRDAMGKKKRRVGGDLHCDYLQRHNKTANRRRTDPVVVLSSILEIIHNELRSMPDVSPFLFPVSAKKVPDYYRVVTKPMDLQTMREYIRQRRYTSREMFLEDLKQIVDNSLIYNGPQSAYTLAAQRMFSSCFELLAEREDKLMRLEKAINPLLDDDDQVALSFIFDKLHSQIKQLPESWPFLKPVNKKQVKDYYTVIKRPMDLETIGKNIEAHRYHSRAEYLADIELIATNCEQYNGSDTRYTKFSKKILEYAQTQLIEFSEHCGQLENNIAKTQERARENAPEFDEAWGNDDYNFDRGSRASSPGDDYIDVEGHGGHASSSNSIHRSMGAEAGSSHTAPAVRKPAPPGPGEVKRGRGRPRKQRDPVEEVKSQNPVKRGRGRPRKDSLASNMSHTQAYFLDEDLQCSTDDEDDDEEEDFQEVSEDENNAASILDQGERINAPADAMDGMFDPKNIKTEIDLEAHQMAEEPIGEDDSQQVAEAMVQLSGVGGYYAQQQQDESMDVDPNYDPSDFLAMHKQRQSLGEPSSLQGAFTNFLSHEQDDNGPYNPAEASTSAASGADLGMDASMAMQMAPEMPVNTMNNGMGIDDDLDISESDEEDDGSRVRIKKEVFDDGDYALQHQQMGQAASQSQIYMVDSSNEPTTLDYQQPPQLDFQQVQEMEQLQHQVMPPMQSEQLQQQQTPQGDNDYAWTF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
81PhosphorylationLKEAEPPSDDEEEED
HHHCCCCCCCHHHHH		69.2920450229
139PhosphorylationLSEDCPRTPPEETST
HCCCCCCCCCCCCCC		28.4722668510
180PhosphorylationPPSAPMRSGSGGGIE
CCCCCCCCCCCCCCC		30.9319429919
182PhosphorylationSAPMRSGSGGGIEEP
CCCCCCCCCCCCCCC		35.2019429919
197PhosphorylationAKSNDASSPSDDSKS
CCCCCCCCCCCCCCC		30.0925749252
275PhosphorylationRRRKRNQSRDQKTTN
HHHHHHHCCCCCCCC		41.1819429919
280PhosphorylationNQSRDQKTTNTGGSD
HHCCCCCCCCCCCCC		21.4619429919
281PhosphorylationQSRDQKTTNTGGSDS
HCCCCCCCCCCCCCC		37.5119429919
283PhosphorylationRDQKTTNTGGSDSPS
CCCCCCCCCCCCCCC		40.6119429919
286PhosphorylationKTTNTGGSDSPSDTE
CCCCCCCCCCCCCCC		35.9419429919
288PhosphorylationTNTGGSDSPSDTEEP
CCCCCCCCCCCCCCH		28.1819429919
290PhosphorylationTGGSDSPSDTEEPRK
CCCCCCCCCCCCHHH		62.2019429919
309PhosphorylationLHYAAEPTPAECMSD
CEEECCCCCHHHCCC		27.0022668510
315PhosphorylationPTPAECMSDDEDKLL
CCCHHHCCCCHHHCC		54.2719429919
596PhosphorylationINVLAEDTPPPPPKS
EEEECCCCCCCCCCC		29.2423607784
603PhosphorylationTPPPPPKSPDRDPFN
CCCCCCCCCCCCCCC		37.4919429919
612PhosphorylationDRDPFNISNDTYYTP
CCCCCCCCCCCEECC		29.7422668510
618PhosphorylationISNDTYYTPKTEPTL
CCCCCEECCCCCCCE		14.1122668510
1123PhosphorylationLQNRVLASSEVLSTD
HHHHHHHHCCCCCCH		23.9119429919
1124PhosphorylationQNRVLASSEVLSTDE
HHHHHHHCCCCCCHH		26.5619429919
1128PhosphorylationLASSEVLSTDEAESS
HHHCCCCCCHHHHHH		38.7019429919
1129PhosphorylationASSEVLSTDEAESSA
HHCCCCCCHHHHHHC		33.4319429919
1134PhosphorylationLSTDEAESSASEESD
CCCHHHHHHCCCHHH		37.9519429919
1135PhosphorylationSTDEAESSASEESDL
CCHHHHHHCCCHHHH		27.5919429919
1137PhosphorylationDEAESSASEESDLEE
HHHHHHCCCHHHHHH		43.7919429919
1140PhosphorylationESSASEESDLEELGK
HHHCCCHHHHHHHHH		43.3619429919
1332PhosphorylationDSGYKEVSPSRKKFK
CCCCCCCCCCHHCCC		20.4627626673
1426PhosphorylationGDDGKRRSGSSSGFT
CCCCCCCCCCCCCCE		47.2419429919
1428PhosphorylationDGKRRSGSSSGFTLK
CCCCCCCCCCCCEEE		23.6819429919
1429PhosphorylationGKRRSGSSSGFTLKV
CCCCCCCCCCCEEEC		37.7019429919
1430PhosphorylationKRRSGSSSGFTLKVP
CCCCCCCCCCEEECC		39.3519429919
1739PhosphorylationFDRGSRASSPGDDYI
CCCCCCCCCCCCCCE		35.6419429919
1740PhosphorylationDRGSRASSPGDDYID
CCCCCCCCCCCCCEE		31.7319429919
1745PhosphorylationASSPGDDYIDVEGHG
CCCCCCCCEECCCCC		12.0819429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TAF1_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TAF1_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TAF1_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TAF4_DROMETaf4physical
19541607
TAF5_DROMETaf5physical
19541607
SAYP_DROMEe(y)3physical
19541607
TBP_DROMETbpphysical
17030624
TAF11_DROMETaf11physical
8276241
TBP_DROMETbpphysical
8170939
TBP_DROMETbpphysical
8276241
TAF2_DROMETaf2physical
25242320
TAF2_DROMETaf2physical
8178153
TAF4_DROMETaf4physical
8276241
TAF12_DROMETaf12physical
8276241
T2AG_DROMETfIIA-Sphysical
7958898
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TAF1_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-286; SER-288; SER-290;SER-603 AND SER-1740, AND MASS SPECTROMETRY.

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