SAYP_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAYP_DROME
• UniProt AC: Q9VWF2
• Protein Name: Supporter of activation of yellow protein
• Gene Name: e(y)3
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2006
• Subcellular Localization: Nucleus . Cytoplasm . Chromosome . On polytene chromosomes, it mainly localizes to transcriptionally active euchromatin sites but also localizes to heterochromatic regions such as the chromocenter and the chromosome 4. Cytoplasmic in nursing cells an
• Protein Description: Essential transcription regulator during early development. Coactivates transcription of some euchromatin genes and repress transcription in of euchromatin genes translocated to heterochromatin..
• Protein Sequence: MNDLRQQQMVAATSSSGSESGTAVESAAATSTAGSAGAAGRPQSNCSANSNAKSVAASSTSEEEQRVSSTSSPAQRDQQLNADRDREQEPEPQQQQQREEALQHQHNQPGHITSTTASPPPTLPPPTTPCDDAPSTTGASASASSASGEAPSAASAAGAAGGPMAATALEVESEERDGHKIILKLSKHANPNSNANESQPGGDERRVEPLRIQLPCGGAEGGLVAKQQDAFDADASSCSSSCAEDEVATTLGQQLRNTPHIVPKLTIRAANERRVGSVVPKLTIKLPENPAASGSNSNSGSCSAAVSGAQSAMPAKNDAHLSSLSPASASSSSASSSSSSSSSSSLAEMQTVPKLMIKTTLAGSSCISSSEELPQQQQQIPKLTIKTGGGGQEHVHTVIMTHDLNNAQSIPKLTIKTKSIEMIEDEQAAKLEQQLQPLPKLTIKNLCSPKHKVRAVLEEKPPTAASKLAIPKPTPNPTPAPMTNGGESNSSSQEFCGFSDPDADIAAPASDDVRRNSDDMVIDDSLSKEHDPKIFHNLPPMPASNGIASGGSKASKASKSAQSQHNVVDMVDLTSSPSPGSSPTHVPNNFTGRISPKGLLIDCLRMQTAIGCYVPEEADSRVRPAASPNSNILLSQLTAPAKSFTTTTPKSKSSKYPQLTERLMANGSGTGGGSVIAAESEAVVGPLPAANPAQSIIESIEILDTPDGSPRVAYMDEDSNPMLNKHLQTIHKLAMDHGVEQRMDTQDNNNENHLKRTNSEGNESPSSRLPPSKQRRLDNDENDQQTQNCHDPARKCSESLQALPPSHRSRKQKHERILNTDLEGSLFPPTQQQSISTPDQNGALSSEVEGEDAKAQDPLEPATPQPPPVATPAGTGKKRGRPKRIQNQSSPDGGGAVTPKPGTPQEEANSAVKSRRVQLLRKRLAIDMVSVGQEQADMKAKEKESSVGVPNARVEDGLAETLESPKTRDHRPLRATRRTTTSTNTNLQPTPKSTRKRQSKASVQQSQLPPPTMAQFGSSESESNNNNNSSISFALSAQIDLTMCSSSSSTSSGAAANQQVIGGSGSSSMLPPTTILSSSDPLPDVIFQPNDFSSIMATQQLRSSRPSSISCGSTGGSQPDCHDEDNYTSALDNSGDETALPMPPTRGRGRGRRSRGGRGRGSSSVDRAVSVGGTASTTPATQPRAPRMSRGASAVAKAIAMSRPRCVGGLKHQPDPERLKGLFSPSPQVFEEDTRMSADLSNSNQSMASLMEPPLTPQKQPDFLNNEESQSSMVSNVSMMDSNQGQSADAILGSALKRPKKKKMETCVAEDTDYSASSIAEYDWPPPKGCCPSKNRDTFMIQEQVALYLGITSFKRKYPDLPRRSVDMEERNWLQEKGLVSEKLCDLGITAVWASDILDIMYADFFDKYEEYKEYIRRKHLREIEAKQKALGLTVGAGRGLQARDRAMLSATKWNAYFNKSRKDERQSCMDLQTFTINQPQPRTAPTCTRLERSTSDLIRAVAEEANIPAPPNLLPPRDYDEAFRNSDYAYPLTVVPDQFSMAYRQFEPAELRAYPLDTALDKPPTDLMAQLLQAKSEAVGSDEIKTSAPAPKDLGQEQSAIKSVTVTAPVRRSRRSTRQQTDKVRTASSSSTSSAQSVSSASSGNGSSSDTESGDESDFSSTSSCSSSTGASSGAGSEDEDGNECSSSVRLSTCGVCLRSQHRNARDMPEAFIRCYTCRKRVHPSCVDMPPRMVGRVRNYNWQCAGCKCCIKCRSSQRPGKMLYCEQCDRGYHIYCLGLRTVPDGRWSCERCCFCMRCGATKPEGLPQVAALSQASGGPSANGDRSKAARNKRLKWVHEYRIDHVTKIREHAAMFCVPCARNKPAKRQSAAGAAGAAAVTPVLEATSAQTDDSPMPSPGLTTNGGRALSPTAALSPKAAVPVASLPPVLEATTVTTNIAGTIGRRQAGNAVNITTMQCSSSSSSNFSGNGVTEDAANVTATGTATAAAGAPAATPIGIAPPPVVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	QRVSSTSSPAQRDQQ HHHCCCCCHHHHHHH	25.09	21082442
277	Phosphorylation	ANERRVGSVVPKLTI CCCCCCCCCCCEEEE	19.65	19429919
419	Phosphorylation	KLTIKTKSIEMIEDE EEEEEECEEEEECHH	29.07	19429919
448	Phosphorylation	LTIKNLCSPKHKVRA CCHHHCCCHHHHHHH	39.90	27626673
517	Phosphorylation	SDDVRRNSDDMVIDD CCCHHHCCCCCEECH	32.93	19429919
627	Phosphorylation	SRVRPAASPNSNILL CCCCCCCCCCCCEEH	27.07	21082442
630	Phosphorylation	RPAASPNSNILLSQL CCCCCCCCCEEHHHC	28.73	21082442
648	Phosphorylation	AKSFTTTTPKSKSSK CCCCCCCCCCCCCCC	26.99	25749252
714	Phosphorylation	DGSPRVAYMDEDSNP CCCCEEEEECCCCCH	11.40	19429919
719	Phosphorylation	VAYMDEDSNPMLNKH EEEECCCCCHHHHHH	40.56	19429919
757	Phosphorylation	NENHLKRTNSEGNES CCCCHHCCCCCCCCC	41.32	25749252
759	Phosphorylation	NHLKRTNSEGNESPS CCHHCCCCCCCCCCH	46.39	25749252
764	Phosphorylation	TNSEGNESPSSRLPP CCCCCCCCCHHCCCH	33.80	25749252
961	Phosphorylation	VEDGLAETLESPKTR CCCCHHHHHCCCCCC	30.16	19429919
964	Phosphorylation	GLAETLESPKTRDHR CHHHHHCCCCCCCCC	34.51	19429919
1224	Phosphorylation	ERLKGLFSPSPQVFE HHHCCCCCCCCHHHC	29.52	19429919
1494	Phosphorylation	TCTRLERSTSDLIRA CCCCCCCCHHHHHHH	23.92	27626673
1817	Phosphorylation	VAALSQASGGPSANG HHHHHHHCCCCCCCC	36.32	22668510
1821	Phosphorylation	SQASGGPSANGDRSK HHHCCCCCCCCCHHH	37.33	22668510
1910	Phosphorylation	TNGGRALSPTAALSP CCCCCCCCCCCCCCC	21.15	19429919
1912	Phosphorylation	GGRALSPTAALSPKA CCCCCCCCCCCCCCC	22.61	29892262
1916	Phosphorylation	LSPTAALSPKAAVPV CCCCCCCCCCCCCCH	21.45	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAYP_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAYP_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAYP_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRM_DROME	brm	physical	19541607
TAF2_DROME	Taf2	physical	19541607
TAF4_DROME	Taf4	physical	19541607
TAF5_DROME	Taf5	physical	19541607
TAF6_DROME	Taf6	physical	19541607
TAF7_DROME	Taf7	physical	19541607
BAP60_DROME	Bap60	physical	19541607
TAF8_DROME	Taf8	physical	19541607
TAF9_DROME	e(y)1	physical	19541607
BRM_DROME	brm	genetic	18299390
HR3_DROME	Hr46	physical	21519192
STAT_DROME	Stat92E	physical	22123744

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.