TAF8_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF8_DROME
• UniProt AC: Q9VWY6
• Protein Name: Transcription initiation factor TFIID subunit 8
• Gene Name: Taf8 {ECO:0000312|EMBL:AAF48800.1}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 328
• Subcellular Localization: Nucleus.
• Protein Description: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors..
• Protein Sequence: MEKVEAVTVSNVDPYRRILNKVVSQLLLDKGAGQASNHSLETLTQMLQALIWEIGNSAHNYCELSGRTMPTVGDVSLALINMGISISNLDPYMRKETHVPIPLPPQQTQQRPLSLLQAGIKAPHPHYVPSYFPPMPDPHAYIRTPTHKQPVTEYEAIREKAACQKRDIEKALTKFLCKTTETNNLFPTEDNMFPLIACKPAFPPYAAALNPTDQVFDFEELEYHYLVANRTEDEPSKDDGEEGDSENEEMDGDKSKEEKPELDIKPNSNTNKAILENPNIDNPYLRAATLPKRSKNCPTPGTMPSRSLATTAPTIRTPSTLEITKTNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
236	Phosphorylation	NRTEDEPSKDDGEEG CCCCCCCCCCCCCCC	46.82	22817900
245	Phosphorylation	DDGEEGDSENEEMDG CCCCCCCCCCCCCCC	53.85	19429919
255	Phosphorylation	EEMDGDKSKEEKPEL CCCCCCCCCCCCCCC	50.46	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF8_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF8_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF8_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAF4_DROME	Taf4	physical	19541607
TAF5_DROME	Taf5	physical	19541607
SAYP_DROME	e(y)3	physical	19541607

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236; SER-245 ANDSER-255, AND MASS SPECTROMETRY.
PubMed: 18327897