TAF5_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TAF5_DROME
• UniProt AC: P49846
• Protein Name: Transcription initiation factor TFIID subunit 5
• Gene Name: Taf5
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 704
• Subcellular Localization: Nucleus.
• Protein Description: TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery..
• Protein Sequence: MSLEVSNINGGNGTQLSHDKRELLCLLKLIKKYQLKSTEELLCQEANVSSVELSEISESDVQQVLGAVLGAGDANRERKHVQSPAQGHKQSAVTEANAAEELAKFIDDDSFDAQHYEQAYKELRTFVEDSLDIYKHELSMVLYPILVQIYFKILASGLREKAKEFIEKYKCDLDGYYIEGLFNLLLLSKPEELLENDLVVAMEQDKFVIRMSRDSHSLFKRHIQDRRQEVVADIVSKYLHFDTYEGMARNKLQCVATAGSHLGEAKRQDNKMRVYYGLLKEVDFQTLTTPAPAPEEEDDDPDAPDRPKKKKPKKDPLLSKKSKSDPNAPSIDRIPLPELKDSDKLLKLKALREASKRLALSKDQLPSAVFYTVLNSHQGVTCAEISDDSTMLACGFGDSSVRIWSLTPAKLRTLKDADSLRELDKESADINVRMLDDRSGEVTRSLMGHTGPVYRCAFAPEMNLLLSCSEDSTIRLWSLLTWSCVVTYRGHVYPVWDVRFAPHGYYFVSCSYDKTARLWATDSNQALRVFVGHLSDVDCVQFHPNSNYVATGSSDRTVRLWDNMTGQSVRLMTGHKGSVSSLAFSACGRYLASGSVDHNIIIWDLSNGSLVTTLLRHTSTVTTITFSRDGTVLAAAGLDNNLTLWDFHKVTEDYISNHITVSHHQDENDEDVYLMRTFPSKNSPFVSLHFTRRNLLMCVGLFKS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	RERKHVQSPAQGHKQ HHHHCCCCCCCCCCH	22.55	19429919
286	Phosphorylation	LKEVDFQTLTTPAPA CEECCCEEECCCCCC	26.51	19429919
288	Phosphorylation	EVDFQTLTTPAPAPE ECCCEEECCCCCCCC	33.84	19429919
289	Phosphorylation	VDFQTLTTPAPAPEE CCCEEECCCCCCCCC	22.14	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TAF5_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TAF5_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TAF5_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSBP_DROME	mtSSB	physical	22036573
PHP_DROME	ph-p	physical	11493925
TAF9_DROME	e(y)1	physical	11493925
PSC_DROME	Psc	physical	11493925
TBP_DROME	Tbp	physical	11493925
TAF4_DROME	Taf4	physical	11493925
PC_DROME	Pc	physical	11493925
TAF12_DROME	Taf12	physical	8276241

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.