| UniProt ID | PC_DROME | |
|---|---|---|
| UniProt AC | P26017 | |
| Protein Name | Polycomb group protein Pc | |
| Gene Name | Pc | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 390 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Component of the PcG multiprotein PRC1 complex, a complex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-118', rendering chromatin heritably changed in its expressibility. Promotes locus-specific chromatin compaction.. | |
| Protein Sequence | MTGRGKGSKGKLGRDNATDDPVDLVYAAEKIIQKRVKKGVVEYRVKWKGWNQRYNTWEPEVNILDRRLIDIYEQTNKSSGTPSKRGIKKKEKEPDPEPESEEDEYTFTENDVDTHQATTSSATHDKESKKEKKHHHHHHHHHHIKSERNSGRRSESPLTHHHHHHHHESKRQRIDHSSSSNSSFTHNSFVPEPDSNSSSSEDQPLIGTKRKAEVLKESGKIGVTIKTSPDGPTIKPQPTQQVTPSQQQPFQDQQQAEKIASEAATQLKSEQQATPLATEAINTTPAESGAEEEEVANEEGNQQAPQVPSENNNIPKPCNNLAINQKQPLTPLSPRALPPRFWLPAKCNISNRVVITDVTVNLETVTIRECKTERGFFRERDMKGDSSPVA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 100 | Phosphorylation | EPDPEPESEEDEYTF CCCCCCCCCCCCCEE | 57.93 | 22668510 | |
| 105 | Phosphorylation | PESEEDEYTFTENDV CCCCCCCCEEECCCC | 21.34 | 23607784 | |
| 106 | Phosphorylation | ESEEDEYTFTENDVD CCCCCCCEEECCCCC | 23.25 | 23607784 | |
| 108 | Phosphorylation | EEDEYTFTENDVDTH CCCCCEEECCCCCCC | 26.53 | 23607784 | |
| 114 | Phosphorylation | FTENDVDTHQATTSS EECCCCCCCHHCCCC | 18.75 | 23607784 | |
| 118 | Phosphorylation | DVDTHQATTSSATHD CCCCCHHCCCCCCCC | 22.20 | 23607784 | |
| 119 | Phosphorylation | VDTHQATTSSATHDK CCCCHHCCCCCCCCC | 24.57 | 23607784 | |
| 120 | Phosphorylation | DTHQATTSSATHDKE CCCHHCCCCCCCCCC | 17.39 | 23607784 | |
| 121 | Phosphorylation | THQATTSSATHDKES CCHHCCCCCCCCCCC | 34.79 | 23607784 | |
| 123 | Phosphorylation | QATTSSATHDKESKK HHCCCCCCCCCCCHH | 32.33 | 23607784 | |
| 128 | Phosphorylation | SATHDKESKKEKKHH CCCCCCCCHHHHCCC | 55.56 | 23607784 | |
| 333 | Phosphorylation | KQPLTPLSPRALPPR CCCCCCCCCCCCCCC | 17.34 | 25749252 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PC_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PC_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PC_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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