SCR_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SCR_DROME
• UniProt AC: P09077
• Protein Name: Homeotic protein Sex combs reduced
• Gene Name: Scr
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 417
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Controls the segmental transformation of the first to the second thoracic segment (prothorax to mesothorax) and of the labial palps into maxillary palps. In embryo, required for fusion of labial lobes and development of the T1 denticle belt. In adult, expression in the head is necessary for proper development of the labium. In the first thoracic segment of the adult, required for proper development of the sex comb and to suppress improper prothoracic wing development..
• Protein Sequence: MDPDCFAMSSYQFVNSLASCYPQQMNPQQNHPGAGNSSAGGSGGGAGGSGGVVPSGGTNGGQGSAGAATPGANDYFPAAAAYTPNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQQQLAQQQHPQQQQQQQQANISCKYANDPVTPGGSGGGGVSGSNNNNNSANSNNNNSQSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNVNVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGETKRQRTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKMASMNIVPYHMGPYGHPYHQFDIHPSQFAHLSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
216	Phosphorylation	DLSTRDISPKLSPSS HCCCCCCCCCCCHHH	21.92	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SCR_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SCR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SCR_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PCL_DROME	Pcl	genetic	6813190
HMPB_DROME	pb	genetic	10322642
HMPB_DROME	pb	genetic	16094438
HTH_DROME	hth	genetic	10395787
MED13_DROME	skd	genetic	11090137
HMG2_DROME	Dsp1	genetic	11139505
EXD_DROME	exd	physical	17981120
EXD_DROME	exd	physical	10398683
EXD_DROME	exd	physical	20634319
SLP2_DROME	slp2	physical	25869471
EYA_DROME	eya	physical	25869471
TF2B_DROME	TfIIB	physical	25869471
SALM_DROME	salm	physical	25869471
SUH_DROME	Su(H)	physical	25869471
TSH_DROME	tsh	physical	25869471
APTE_DROME	ap	physical	25869471
MEF2_DROME	Mef2	physical	25869471
EVE_DROME	eve	physical	25869471
MAM_DROME	mam	physical	25869471
TWIST_DROME	twi	physical	25869471
DLL_DROME	Dll	physical	25869471
MED19_DROME	MED19	physical	24786462
KNIR_DROME	kni	physical	25869471
SCR_DROME	Scr	physical	22564794
SCR_DROME	Scr	physical	26428533
POXM_DROME	Poxm	physical	25869471
HTH_DROME	hth	physical	20634319
EMS_DROME	ems	physical	25869471
SRP_DROME	srp	physical	25869471
TIN_DROME	tin	physical	25869471
BAGP_DROME	bap	physical	25869471
SLOU_DROME	slou	physical	25869471
PNT1_DROME	pnt	physical	25869471
PNT2_DROME	pnt	physical	25869471
MYOD_DROME	nau	physical	25869471
ZFH1_DROME	zfh1	physical	25869471
PNR_DROME	pnr	physical	25869471
COLL_DROME	kn	physical	25869471

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, AND MASSSPECTROMETRY.
PubMed: 18327897