PNR_DROME - dbPTM
PNR_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PNR_DROME
UniProt AC P52168
Protein Name GATA-binding factor A
Gene Name pnr
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 540
Subcellular Localization Nucleus.
Protein Description Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes..
Protein Sequence MGILLSDGDSTSDQQSTRDYPHFSGDYQNVTLSAASASTSASASATHVAAVKMYHSSAVAAYTDLAAAGSAASAGVGVGVSGYHQQAVNAPVYVPSNRQYNHVAAHFGSAAAQNAWTTEGFGSAHAQFYSPNAAVMMGSWRSAYDPSGFQRSSPYESAMDFQFGEGRECVNCGAISTPLWRRDGTGHYLCNACGLYHKMNGMNRPLIKPSKRLVSATATRRMGLCCTNCGTRTTTLWRRNNDGEPVCNACGLYYKLHGVNRPLAMRKDGIQTRKRKPKKTGSGSAVGAGTGSGTGSTLEAIKECKEEHDLKPSLSLERHSLSKLHTDMKSGTSSSSTLMGHHSAQQQQQQQQQQQQQQQQQQQQSAHQQCFPLYGQTTTQQQHQQHGHSMTSSSGQAHLSARHLHGAAGTQLYTPGSSSGGGSASAYTSHSAETPALSNGTPSPHYQHHHHLGGTHGHHVTAAAAHHHFHAAAAVAAYGVKTEASATNYDYVNNCYFGGTFGALGGAATTTAMAGGAASELAGYHHQHNVIQAAKLMATS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
313PhosphorylationEEHDLKPSLSLERHS
HHCCCCCCCHHHHHH
29.0619429919
315PhosphorylationHDLKPSLSLERHSLS
CCCCCCCHHHHHHHH
32.3019429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PNR_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PNR_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PNR_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CBPD_DROMEsvrgenetic
11901120
HR4_DROMEHr4genetic
11901120
DAPKR_DROMEDrakgenetic
11901120
SCAL_DROMEsdgenetic
11901120
AMN_DROMEamngenetic
11901120
SMO_DROMEsmogenetic
11901120
USH_DROMEushgenetic
9367989
DECA_DROMEdppgenetic
11901120
H15_DROMEH15genetic
19494035
WNTG_DROMEwggenetic
10662640
BIB_DROMEbibgenetic
11901120
BUN1_DROMEbungenetic
11901120
BUN2_DROMEbungenetic
11901120
ELBOW_DROMEelBgenetic
11901120
ESCA_DROMEesggenetic
11901120
SPITZ_DROMEspigenetic
11901120
FTF1B_DROMEHr39genetic
11901120
EAF_DROMEEafgenetic
11901120
PTC_DROMEptcgenetic
11901120
MEF2_DROMEMef2genetic
11901120
ISWI_DROMEIswigenetic
16141224
CHN_DROMEchngenetic
15703278
GSTS1_DROMEGstS1genetic
11901120
FMR1_DROMEFmr1genetic
11901120
EMC_DROMEemcgenetic
11901120
HDAC1_DROMERpd3genetic
18773887
LIN28_DROMElin-28genetic
11901120
AKIRN_DROMEakiringenetic
11901120
CHRB_DROMEchrbgenetic
11901120
PDI_DROMEPdigenetic
11901120
PICAL_DROMElapgenetic
11901120
PUM_DROMEpumgenetic
11901120
CPD1_DROMED1genetic
11901120
CTBP_DROMECtBPgenetic
11901120
CTBP_DROMECtBPgenetic
18773887
TRX_DROMEtrxgenetic
11901120
KIBRA_DROMEkibragenetic
11901120
ATX2_DROMEAtx2genetic
11901120
OSA_DROMEosagenetic
12629041
TIN_DROMEtingenetic
16221729
GLEC_DROMEglecgenetic
11901120
OCTL_DROMEOrct2genetic
11901120
ATRX_DROMEXNPgenetic
11901120
ATRX_DROMEXNPgenetic
22021382
TOLL_DROMETlgenetic
11901120
MPIP_DROMEstggenetic
11901120
IMDH_DROMErasgenetic
11901120
WECH_DROMEwechgenetic
11901120
HMG2_DROMEDsp1genetic
11901120
ZER1_DROMECG12084genetic
11901120
HSP22_DROMEHsp22genetic
11901120
MED21_DROMEMED21physical
25242320

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PNR_DROME

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Related Literatures of Post-Translational Modification

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