TOLL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TOLL_DROME
• UniProt AC: P08953
• Protein Name: Protein toll
• Gene Name: Tl {ECO:0000312|FlyBase:FBgn0262473}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1097
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cytoplasm . In the fat body, detected in puntate structures along the cell periphery. Becomes evenly distributed in the cytoplasm 1 hour after bacterial infection.
• Protein Description: Receptor for the cleaved activated form of spz, spaetzle C-106. [PubMed: 12872120 Binding to spaetzle C-106 activates the Toll signaling pathway and induces expression of the antifungal peptide drosomycin]
• Protein Sequence: MSRLKAASELALLVIILQLLQWPGSEASFGRDACSEMSIDGLCQCAPIMSEYEIICPANAENPTFRLTIQPKDYVQIMCNLTDTTDYQQLPKKLRIGEVDRVQMRRCMLPGHTPIASILDYLGIVSPTTLIFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRLMNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSLFAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDLSYNNISSLGYEDLAFLSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHKPQYSRQFKLRTDRLVCSQPNVLEGTPVRQIEPQTLICPLDFSDDPRERKCPRGCNCHVRTYDKALVINCHSGNLTHVPRLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVDQLPTNLTHLDISWNHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCDCTAKPLLLFTQDNFERIGDRNEMMCVNAEMPTRMVELSTNDICPAEKGVFIALAVVIALTGLLAGFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQLCVHERDWLVGGHIPENIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALNEGRSRIIVIIYSDIGDVEKLDEELKAYLKMNTYLKWGDPWFWDKLRFALPHRRPVGNIGNGALIKTALKGSTDDKLELIKPSPVTPPLTTPPAEATKNPLVAQLNGVTPHQAIMIANGKNGLTNLYTPNGKSHGNGHINGAFIINTNAKQSDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	N-linked_Glycosylation	DYVQIMCNLTDTTDY HEEEEEECCCCCCCH	28.70	23596340
140	N-linked_Glycosylation	ESDNLGMNITRQHLD CCCCCCCCHHHHHHH	30.59	23596340
175	N-linked_Glycosylation	NLLTDMRNLSHLELR HHHHHCCCCCHHHHH	38.98	24733933
235	N-linked_Glycosylation	LWSNQLHNLTKHDFE CHHHHHHHCCCCCCC	58.98	24733933
270	N-linked_Glycosylation	DVFAHLTNVTDINLS CHHHHCCCCCCCCCC	40.84	24282309
275	N-linked_Glycosylation	LTNVTDINLSANLFR CCCCCCCCCCHHHHH	30.65	-
346	N-linked_Glycosylation	EHSTQITNISLGDNL HCCCEEEECCCCCCH	24.39	24282309
391	N-linked_Glycosylation	SLFAHTTNLTDLRLE HHCCCCCCCCCCCHH	41.94	24282309
482	N-linked_Glycosylation	LLTLNLRNNSIIFVY EEEEECCCCEEEEEE	50.17	24733933
508	N-linked_Glycosylation	ELDLSYNNISSLGYE HCCCCCCCHHHCCHH	27.56	24733933
528	N-linked_Glycosylation	SQNRLHVNMTHNKIR CCCCEEEECCCCHHH	20.91	24733933
654	N-linked_Glycosylation	VINCHSGNLTHVPRL EEECCCCCCCCCCCC	44.79	24733933
677	N-linked_Glycosylation	LMELHLENNTLLRLP EEEEECCCCCEEECC	53.82	-
703	N-linked_Glycosylation	SLHLAGNNLTSIDVD EEEECCCCCCCCCHH	43.72	24733933
715	N-linked_Glycosylation	DVDQLPTNLTHLDIS CHHHCCCCCCCCCCC	40.79	24733933
730	N-linked_Glycosylation	WNHLQMLNATVLGFL CHHHHHHHHHHHHHH	28.37	-
738	N-linked_Glycosylation	ATVLGFLNRTMKWRS HHHHHHHHCCCCCEE	34.81	-
871	Phosphorylation	SYSHKDQSFIEDYLV ECCCCCHHHHHHHCH	38.02	18327897
1026	Phosphorylation	KLELIKPSPVTPPLT CCEECCCCCCCCCCC	27.31	19429919
1029	Phosphorylation	LIKPSPVTPPLTTPP ECCCCCCCCCCCCCC	23.67	19429919
1033	Phosphorylation	SPVTPPLTTPPAEAT CCCCCCCCCCCHHHC	42.93	19429919
1034	Phosphorylation	PVTPPLTTPPAEATK CCCCCCCCCCHHHCC	34.65	19429919
1040	Phosphorylation	TTPPAEATKNPLVAQ CCCCHHHCCCCHHHH	23.90	19429919
1070	Phosphorylation	KNGLTNLYTPNGKSH CCCCEEEECCCCCCC	23.40	19429919
1071	Phosphorylation	NGLTNLYTPNGKSHG CCCEEEECCCCCCCC	17.28	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TOLL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TOLL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TOLL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DECA_DROME	dpp	genetic	10903186
CACT_DROME	cact	genetic	7705656
DIF_DROME	Dif	genetic	26090908
FAS3_DROME	Fas3	genetic	10366624
AKT1_DROME	Akt1	genetic	19861550
STAT_DROME	Stat92E	genetic	12454071
SPZ_DROME	spz	genetic	19018662
GPRK2_DROME	Gprk2	genetic	20421637
TOLL_DROME	Tl	physical	11881810
TOLL_DROME	Tl	physical	23827685
TOLL_DROME	Tl	physical	15795223
TOLL_DROME	Tl	physical	18347020
SPZ_DROME	spz	physical	12872120
SPZ_DROME	spz	physical	24282309
SPZ_DROME	spz	physical	24733933
SPZ_DROME	spz	physical	15795223
SPZ_DROME	spz	physical	18347020
SPZ_DROME	spz	physical	23729564
KPEL_DROME	pll	physical	11881810
WEK_DROME	wek	physical	16782008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.