KPEL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KPEL_DROME
• UniProt AC: Q05652
• Protein Name: Serine/threonine-protein kinase pelle
• Gene Name: pll
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 501
• Subcellular Localization: Cell membrane . Cytoplasm . Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei.
• Protein Description: Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll..
• Protein Sequence: MSGVQTAEAEAQAQNQANGNRTRSRSHLDNTMAIRLLPLPVRAQLCAHLDALDVWQQLATAVKLYPDQVEQISSQKQRGRSASNEFLNIWGGQYNHTVQTLFALFKKLKLHNAMRLIKDYVSEDLHKYIPRSVPTISELRAAPDSSAKVNNGPPFPSSSGVSNSNNNRTSTTATEEIPSLESLGNIHISTVQRAAESLLEIDYAELENATDGWSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVLKRFEPFVTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
169	Phosphorylation	SNSNNNRTSTTATEE CCCCCCCCCCCCCCC	32.33	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KPEL_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KPEL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KPEL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPEL_DROME	pll	physical	24086459
CACT_DROME	cact	physical	24086459
DORS_DROME	dl	physical	9367441
DORS_DROME	dl	physical	9405646
TUBE_DROME	tub	physical	10330490
TUBE_DROME	tub	physical	7527496
TUBE_DROME	tub	physical	10589682
TUBE_DROME	tub	physical	10512628
TUBE_DROME	tub	physical	7635064
TUBE_DROME	tub	physical	9367441
FLNA_DROME	cher	physical	9367441
PELI_DROME	Pli	physical	24632597
PELI_DROME	Pli	physical	10330490
KPEL_DROME	pll	physical	11881810
KPEL_DROME	pll	physical	7527496

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.