TUBE_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TUBE_DROME
• UniProt AC: P22812
• Protein Name: Protein Tube
• Gene Name: tub
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 462
• Subcellular Localization: Cytoplasm . Cell membrane . Associates with the plasma membrane during interphase syncytial blastoderm embryos, more specifically at the membrane invaginations around the nuclei. Later in embryonic development protein is entirely cytoplasmic.
• Protein Description: Plays an essential role in the Tl receptor signaling pathway that establishes embryonic dorsoventral polarity; the signal directs import of dl into ventral and ventrolateral nuclei, thereby establishing dorsoventral polarity. Tub recruits pll to the plasma membrane and protein-protein interaction activates pll. Also has a role in pupal pattern formation..
• Protein Sequence: MAYGWNGCGMGVQVNGSNGAIGLSSKYSRNTELRRVEDNDIYRLAKILDENSCWRKLMSIIPKGMDVQACSGAGCLNFPAEIKKGFKYTAQDVFQIDEAANRLPPDQSKSQMMIDEWKTSGKLNERPTVGVLLQLLVQAELFSAADFVALDFLNESTPARPVDGPGALISLELLEEEMEVDNEGLSLKYQSSTATLGADAQGSVGLNLDNFEKDIVRRDKSVPQPSGNTPPIAPPRRQQRSTTNSNFATLTGTGTTSTTIPNVPNLTILNPSEQIQEPVLQPRPMNIPDLSILISNSGDLRATVSDNPSNRTSSTDPPNIPRITLLIDNSGDVNSRPNHAPAKASTATTSTASSNNLPMISALNISKGSRETLRPESRSSSSSLSKDDDDDNDGEEDGEEEYPDAFLPNLSNSEQQSSNNDSSLTTVTGTSGDNSFELTNDSSSTSNDDYACNIPDLSELQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
229	Phosphorylation	VPQPSGNTPPIAPPR CCCCCCCCCCCCCCC	33.69	21082442
309	Phosphorylation	ATVSDNPSNRTSSTD EEECCCCCCCCCCCC	45.24	25749252
313	Phosphorylation	DNPSNRTSSTDPPNI CCCCCCCCCCCCCCC	28.18	21082442
314	Phosphorylation	NPSNRTSSTDPPNIP CCCCCCCCCCCCCCC	35.90	21082442
324	Phosphorylation	PPNIPRITLLIDNSG CCCCCEEEEEECCCC	19.45	21082442
377	Phosphorylation	RETLRPESRSSSSSL HHHCCCCCCCCCCCC	39.90	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TUBE_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TUBE_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TUBE_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CACT_DROME	cact	physical	9367441
DORS_DROME	dl	physical	9367441
DORS_DROME	dl	physical	9405646
FLNA_DROME	cher	physical	9367441
PELI_DROME	Pli	physical	24632597
KPEL_DROME	pll	physical	10330490
KPEL_DROME	pll	physical	7527496

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.