CACT_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CACT_DROME
• UniProt AC: Q03017
• Protein Name: NF-kappa-B inhibitor cactus
• Gene Name: cact
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 500
• Subcellular Localization: Cytoplasm .
• Protein Description: Involved in the formation of the dorsoventral pattern. It inhibits nuclear translocation of the dorsal morphogen in the dorsal region of the embryo. Acts as a negative regulator of the NF-kappa-B (rel) signaling pathway. Cact is degraded by IKKbeta, this is essential for NF-kappa-B (rel) activation..
• Protein Sequence: MPSPTKAAEAATKATATSDCSCSAASVEQRAPSNAANPSSSLATSGKIGGKTQDQTAAINKQKEFAVPNETSDSGFISGPQSSQIFSEEIVPDSEEQDKDQQESAPQKEQPVVLDSGIIDEEEDQEEQEKEEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVSRGEQLNNLGQSSSTQITGRSKVQSSTASTANANPSGSGATSSAPPSSINIMNAWEQFYQQNDDGDTPLHLACISGSVDVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEPTVRDRHGNTALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSYACLPADLEIRNYDGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECEKLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAETVTPPDSDYDSSDIEDLDDTKMYDRFGDPRYFVSYNGGNPMTVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	PSSSLATSGKIGGKT CCCCCCCCCCCCCCC	32.27	-
144	Phosphorylation	TTTATADSMRLKHSA HHHHHHHHHHHHCCC	11.88	-
159	Phosphorylation	DTGIPQWTVESHLVS CCCCCCCCHHHHHHC	14.78	22817900
162	Phosphorylation	IPQWTVESHLVSRGE CCCCCHHHHHHCHHH	20.13	22817900
166	Phosphorylation	TVESHLVSRGEQLNN CHHHHHHCHHHHHHC	40.71	22817900
183	Phosphorylation	QSSSTQITGRSKVQS CCCCCCCCCCHHCEE	19.41	-
293	Phosphorylation	LLAGAEPTVRDRHGN HHCCCCCCCCCCCCC	21.48	-
319	Phosphorylation	KQCVRALTEKFGATE HHHHHHHHHHHCCHH	35.82	-
395	Phosphorylation	INAREGKSGRTPLHI CCCCCCCCCCCCEEE	44.35	-
459	Phosphorylation	KRGAETVTPPDSDYD HCCCCCCCCCCCCCC	36.20	19429919
463	Phosphorylation	ETVTPPDSDYDSSDI CCCCCCCCCCCCCCC	43.79	19429919
465	Phosphorylation	VTPPDSDYDSSDIED CCCCCCCCCCCCCCC	22.98	19429919
467	Phosphorylation	PPDSDYDSSDIEDLD CCCCCCCCCCCCCCC	24.55	19429919
468	Phosphorylation	PDSDYDSSDIEDLDD CCCCCCCCCCCCCCC	39.44	19429919
476	Phosphorylation	DIEDLDDTKMYDRFG CCCCCCCCCCCCCCC	19.85	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
45	S	Phosphorylation	Kinase	PKC	-	Uniprot
144	S	Phosphorylation	Kinase	PKC	-	Uniprot
183	T	Phosphorylation	Kinase	PKC	-	Uniprot
293	T	Phosphorylation	Kinase	PKC	-	Uniprot
319	T	Phosphorylation	Kinase	PKC	-	Uniprot
395	S	Phosphorylation	Kinase	PKC	-	Uniprot
468	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
468	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM
468	S	Phosphorylation	Kinase	CKII_GROUP	-	PhosphoELM

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CACT_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CACT_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FMR1_DROME	Fmr1	physical	14605208
DORS_DROME	dl	physical	14605208
CP6T3_DROME	Cyp6t3	physical	14605208
SOG_DROME	sog	genetic	10903186
CATIN_DROME	cactin	genetic	10842059
GRK_DROME	grk	genetic	11133153
DIF_DROME	Dif	genetic	26090908
DORS_DROME	dl	genetic	11133153
TUBE_DROME	tub	genetic	9550723
EAST_DROME	ea	genetic	11133153
TOLL_DROME	Tl	genetic	9550723
SPZ_DROME	spz	genetic	11133153
KPEL_DROME	pll	genetic	9550723
FUSIL_DROME	fus	genetic	11133153
CACT_DROME	cact	physical	23864715
CACT_DROME	cact	physical	9367441
DIF_DROME	Dif	physical	7479760
DIF_DROME	Dif	physical	7791770
DORS_DROME	dl	physical	1423619
DORS_DROME	dl	physical	7479760
DORS_DROME	dl	physical	7791770
DORS_DROME	dl	physical	8227123
DORS_DROME	dl	physical	9367441
DORS_DROME	dl	physical	12653959
DORS_DROME	dl	physical	1423618
DORS_DROME	dl	physical	9405646
DORS_DROME	dl	physical	22654665
DORS_DROME	dl	physical	8202491
CANA_DROME	CalpA	physical	23864715
NFKB1_DROME	Rel	physical	22654665
GPRK2_DROME	Gprk2	physical	20421637

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.