CANA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CANA_DROME
• UniProt AC: Q11002
• Protein Name: Calpain-A
• Gene Name: CalpA
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 828
• Subcellular Localization: Cytoplasm .
• Protein Description: Calcium-regulated non-lysosomal thiol-protease. Involved in the organization of the actin-related cytoskeleton during embryogenesis..
• Protein Sequence: MDDLRGFLRQAGQEFLNAAGEAAMGAAKDVVGSVINEIFIKKEADTKRVLPSIKNMRVLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTIYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
230	Phosphorylation	YAKLHGSYEALKGGS HHHHHCCHHHHCCCC	15.15	28490779
237	Phosphorylation	YEALKGGSTCEAMED HHHHCCCCCCCEEHH	38.25	28490779
238	Phosphorylation	EALKGGSTCEAMEDF HHHCCCCCCCEEHHH	20.03	28490779
246	Phosphorylation	CEAMEDFTGGVSEWY CCEEHHHCCCCCEEE	45.40	28490779
250	Phosphorylation	EDFTGGVSEWYDLKE HHHCCCCCEEEECCC	26.20	28490779
253	Phosphorylation	TGGVSEWYDLKEAPG CCCCCEEEECCCCCC	13.82	28490779
387	Phosphorylation	RVEICNLSPDSLTED CEEEECCCHHCCCHH	16.81	22817900
398	Phosphorylation	LTEDQQNSGKRKWEM CCHHHHHHCCCEEEE	41.16	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CANA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CANA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CANA_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of CANA_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.