dbPTM

NFKB1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NFKB1_DROME
UniProt AC	Q94527
Protein Name	Nuclear factor NF-kappa-B p110 subunit
Gene Name	Rel {ECO:0000312\|FlyBase:FBgn0014018}
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	971
Subcellular Localization	Nuclear factor NF-kappa-B p68 subunit: Nucleus. Nuclear factor NF-kappa-B p110 subunit: Cytoplasm. Nuclear factor NF-kappa-B p49 subunit: Cytoplasm.
Protein Description	Plays a key role in the humoral immune response. [PubMed: 8816802]
Protein Sequence	MNMNQYYDLDNGKNVMFMNDASSTSGYSSSTSPNSTNRSFSPAHSPKTMELQTDFANLNLPGGNSPHQPPMANSPYQNQLLNNGGICQLGATNLINSTGVSFGVANVTSFGNMYMDHQYFVPAPATVPPSQNFGYHQNGLASDGDIKHVPQLRIVEQPVEKFRFRYKSEMHGTHGSLNGANSKRTPKTFPEVTLCNYDGPAVIRCSLFQTNLDSPHSHQLVVRKDDRDVCDPHDLHVSKERGYVAQFINMGIIHTAKKYIFEELCKKKQDRLVFQMNRRELSHKQLQELHQETEREAKDMNLNQVRLCFEAFKIEDNGAWVPLAPPVYSNAINNRKSAQTGELRIVRLSKPTGGVMGNDELILLVEKVSKKNIKVRFFEEDEDGETVWEAYAKFRESDVHHQYAIVCQTPPYKDKDVDREVNVYIELIRPSDDERSFPALPFRYKPRSVIVSRKRRRTGSSANSSSSGTESSNNSLDLPKTLGLAQPPNGLPNLSQHDQTISEEFGREKHLNEFIASEDFRKLIEHNSSDLEKICQLDMGELQHDGHNRAEVPSHRNRTIKCLDDLFEIYKQDRISPIKISHHKVEKWFIEHALNNYNRDTLLHEVISHKKDKLKLAIQTIQVMNYFNLKDVVNSTLNADGDSALHVACQQDRAHYIRPLLGMGCNPNLKNNAGNTPLHVAVKEEHLSCVESFLNGVPTVQLDLSLTNDDGLTPLHMAIRQNKYDVAKKLISYDRTSISVANTMDGNNALHMAVLEQSVELLVLILDAQNENLTDILQAQNAAGHTPLELAERKANDRVVQLLKNVYPEKGELAMTWIPCKVKEEIDSSSDESSDAGQLEIKSEEMDIETKDEDSVELDLSSGPRRQKDESSRDTEMDNNKLQLLLKNKFIYDRLCSLLNQPLGHGSDPQDRKWMQLARQTHLKQFAFIWLGAEDLLDHVKRKGASVEFSTFARALQAVDPQAYALLVNPT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	SPNSTNRSFSPAHSP CCCCCCCCCCCCCCC	31.95	19429919
41	Phosphorylation	NSTNRSFSPAHSPKT CCCCCCCCCCCCCCE	23.56	19429919
45	Phosphorylation	RSFSPAHSPKTMELQ CCCCCCCCCCEEEEE	30.14	19429919
431	Phosphorylation	YIELIRPSDDERSFP EEEEECCCCCCCCCC	48.09	19135474
500	Phosphorylation	NLSQHDQTISEEFGR CCHHHCHHHHHHHCC	32.31	19429919
502	Phosphorylation	SQHDQTISEEFGREK HHHCHHHHHHHCCHH	34.17	19429919
517	Phosphorylation	HLNEFIASEDFRKLI HHHHHHHCHHHHHHH	32.65	19429919
528	Phosphorylation	RKLIEHNSSDLEKIC HHHHHCCCCHHHHHH	27.43	19429919
529	Phosphorylation	KLIEHNSSDLEKICQ HHHHCCCCHHHHHHC	52.08	19429919
620	Phosphorylation	KLKLAIQTIQVMNYF HHHHHHHHHHHHCCC	13.78	22817900
626	Phosphorylation	QTIQVMNYFNLKDVV HHHHHHCCCCHHHHH	3.92	22817900
828	Phosphorylation	KVKEEIDSSSDESSD EEEEECCCCCCCCCC	37.09	19429919
829	Phosphorylation	VKEEIDSSSDESSDA EEEECCCCCCCCCCC	37.75	19429919
830	Phosphorylation	KEEIDSSSDESSDAG EEECCCCCCCCCCCC	49.72	19429919
833	Phosphorylation	IDSSSDESSDAGQLE CCCCCCCCCCCCCEE	38.21	19429919
834	Phosphorylation	DSSSDESSDAGQLEI CCCCCCCCCCCCEEE	29.45	19429919
950	Phosphorylation	KGASVEFSTFARALQ CCCCCCHHHHHHHHH	14.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
431	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
431	S	Phosphorylation	Kinase	PKA	-	Uniprot
431	S	Phosphorylation	Kinase	PKA_GROUP	-	PhosphoELM
528	S	Phosphorylation	Kinase	IRD5	Q9VEZ5	GPS
529	S	Phosphorylation	Kinase	IRD5	Q9VEZ5	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NFKB1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NFKB1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IKKB_DROME	ird5	physical	22036573
NEMO_DROME	key	physical	22036573
MSL3_DROME	msl-3	physical	23749869
NH2L1_DROME	hoip	physical	23749869
RL7A_DROME	RpL7A	physical	23749869
MIC60_DROME	CG6455	physical	23749869
RS17_DROME	RpS17	physical	23749869
CATA_DROME	Cat	physical	23749869
NCD_DROME	ncd	physical	23749869
GBLP_DROME	Rack1	physical	23749869
RS21_DROME	RpS21	physical	23749869
NFKB1_DROME	Rel	physical	23749869
TBB1_DROME	betaTub56D	physical	23749869
JUPIT_DROME	Jupiter	physical	23749869
RS3_DROME	RpS3	physical	23749869
HSP7D_DROME	Hsc70-4	physical	23749869
SOYB_DROME	SoYb	physical	23749869
CH60C_DROME	Hsp60C	physical	23749869
RUVB1_DROME	pont	physical	23749869
TCPG_DROME	Cctgamma	physical	23749869
STIM_DROME	Stim	physical	23749869
RS20_DROME	RpS20	physical	23749869
CH60_DROME	Hsp60	physical	23749869
RS16_DROME	RpS16	physical	23749869
ATC1_DROME	Ca-P60A	physical	23749869
HCD2_DROME	scu	physical	23749869
Y3800_DROME	CG3800	physical	23749869
ATPA_DROME	blw	physical	23749869
SODC_DROME	Sod	physical	23749869
ADT_DROME	sesB	physical	23749869
HCF_DROME	Hcf	physical	23749869
S39AD_DROME	Zip99C	physical	23749869
IF2A_DROME	eIF-2alpha	physical	23749869
CADF_DROME	tsr	physical	23749869
RS28_DROME	RpS28b	physical	23749869
EF2_DROME	EF2	physical	23749869
RL22_DROME	RpL22	physical	23749869
TBA2_DROME	alphaTub85E	physical	23749869
TBA3_DROME	alphaTub84D	physical	23749869
TBA1_DROME	alphaTub84B	physical	23749869
NU153_DROME	Nup153	physical	23749869
TAF6_DROME	Taf6	physical	23749869
CATL_DROME	Cp1	physical	23749869
MA205_DROME	Map205	physical	23749869
EF1A1_DROME	Ef1alpha48D	physical	23749869
EF1A2_DROME	Ef1alpha100E	physical	23749869
ANLN_DROME	scra	physical	23749869
LIG_DROME	lig	physical	23749869
CUP_DROME	cup	physical	23749869
CREBB_DROME	CrebB	physical	23749869
PRDX1_DROME	Jafrac1	physical	23749869
ZASP_DROME	Zasp52	physical	23749869
CP190_DROME	Cp190	physical	23749869
CTBP_DROME	CtBP	physical	23749869
TAF4_DROME	Taf4	physical	23749869
SMD2_DROME	SmD2	physical	23749869
AST4_DROME	sc	genetic	18000549
CASP8_DROME	Dredd	genetic	18000549
TOLL_DROME	Tl	genetic	12032070
SPZ_DROME	spz	genetic	12032070
CACT_DROME	cact	physical	22654665
CACT_DROME	cact	physical	12653959
DIF_DROME	Dif	physical	22654665
DORS_DROME	dl	physical	22654665
TIM10_DROME	Tim10	physical	25242320
NEMO_DROME	key	physical	25242320
AKIRN_DROME	akirin	physical	25180232
NFKB1_DROME	Rel	physical	22654665
BRC1_DROME	br	physical	25931442
BRC4_DROME	br	physical	25931442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NFKB1_DROME

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-620 AND TYR-626, ANDMASS SPECTROMETRY.	18327897 [Abstract]