STIM_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STIM_DROME
• UniProt AC: P83094
• Protein Name: Stromal interaction molecule homolog
• Gene Name: Stim
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 570
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores..
• Protein Sequence: MRKNTIWNYSLIFFCCVLKSISTLDHGPHTVSVDSNRHNTQHQYKQNPNVASQRHSSHESGQSLHNSQSEHVTHIAASHAGSGGEHSTHLAQNLHRSSYNLLSEAMSQAVSNEFSSMGSGSADGACAADDFDCYSGSVQDRFGMEAIASLHRQLDDDDNGNIDLSESDDFLREELKYDSGYEKRQKAFHFNDDMHISVKELWEAWLRSEVHNWTIEQTTDWLAQSVQLPQYVDLFKLHKVTGAALPRLAVNNLQYVGNVLGIKDPIHKQKISLKAMDVVLFGPPRETGTRWKDYILVTLLLSAIIGCWYAYQQNKNAKRHLRRMAQDMEGLQRAEQSLQEMQKELERARMEQENVATEKLDLERRLKEAPTLSSSNSDLEVQQLKKEIEMLRNELSRAEFELVDNCWSPPPQLQSWLQYTYELESKNHQKKRTSAEKQLQSAREACEKLRKKRSSLVGAFVSTHGKSIDDVDRSIVEARNALGDVTNELQERLHRWKQIETCLGLNIVNNNGLPYLENVLYGRNGGLQSSMGMSSTKGSRARITNSTEDLDDESIQGKLNFENFSLLATE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
212	N-linked_Glycosylation	WLRSEVHNWTIEQTT HHHHHHCCCCHHHHH	42.64	-
373	Phosphorylation	LKEAPTLSSSNSDLE HHHCCCCCCCCCHHH	33.91	19429919
374	Phosphorylation	KEAPTLSSSNSDLEV HHCCCCCCCCCHHHH	36.33	19429919
375	Phosphorylation	EAPTLSSSNSDLEVQ HCCCCCCCCCHHHHH	36.66	22668510
377	Phosphorylation	PTLSSSNSDLEVQQL CCCCCCCCHHHHHHH	45.58	19429919
454	Phosphorylation	EKLRKKRSSLVGAFV HHHHHHHHHHHHHHH	36.58	19429919
455	Phosphorylation	KLRKKRSSLVGAFVS HHHHHHHHHHHHHHH	30.98	19429919
539	Phosphorylation	GMSSTKGSRARITNS CCCCCCCCCCCCCCC	25.07	22817900
544	Phosphorylation	KGSRARITNSTEDLD CCCCCCCCCCCCCCC	19.98	23607784
546	Phosphorylation	SRARITNSTEDLDDE CCCCCCCCCCCCCCC	25.23	16208375
547	Phosphorylation	RARITNSTEDLDDES CCCCCCCCCCCCCCH	35.27	23607784
554	Phosphorylation	TEDLDDESIQGKLNF CCCCCCCHHCCCCCC	27.49	25749252

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STIM_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STIM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STIM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	genetic	18950512
STIM_DROME	Stim	physical	18820677
CRCM1_DROME	olf186-F	physical	16921385
CRCM1_DROME	olf186-F	physical	27591258

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-539 AND SER-546, ANDMASS SPECTROMETRY.
PubMed: 18327897