| UniProt ID | CRCM1_DROME | |
|---|---|---|
| UniProt AC | Q9U6B8 | |
| Protein Name | Calcium release-activated calcium channel protein 1 | |
| Gene Name | olf186-F | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 351 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores. Regulates transcription factor NFAT nuclear import.. | |
| Protein Sequence | MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVATGHQFQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFPPPPPPSSQNQAKPRGHHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVPPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFSTLLGLILFLLEIAILCWVKFYDLSPPAAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVSGIRELEMLKEQMEQDHLEHHNNIRNNGMNYGASGDIV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 83 (in isoform 3) | Phosphorylation | - | 45.06 | 23607784 | |
| 85 (in isoform 3) | Phosphorylation | - | 33.13 | 29892262 | |
| 86 (in isoform 3) | Phosphorylation | - | 41.34 | 29892262 | |
| 134 | Phosphorylation | RTASSSMSQSGEDLH CCCCCCCCCCCCCCC | 24.12 | 19429919 | |
| 136 | Phosphorylation | ASSSMSQSGEDLHSP CCCCCCCCCCCCCCC | 36.52 | 19429919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CRCM1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CRCM1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CRCM1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| GSC_DROME | Gsc | physical | 14605208 | |
| STIM_DROME | Stim | physical | 16921385 | |
| STIM_DROME | Stim | physical | 27591258 | |
| CRCM1_DROME | olf186-F | physical | 23180775 | |
| CRCM1_DROME | olf186-F | physical | 18820677 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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