| UniProt ID | NOTCH_DROME | |
|---|---|---|
| UniProt AC | P07207 | |
| Protein Name | Neurogenic locus Notch protein | |
| Gene Name | N | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 2703 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Endosome . Transported to early endosomes by O-fut1 (PubMed:17329366). Processed neurogenic locus Notch protein: Nucleus. Upon activation and S3 cleavage, it is released from the cell membra |
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| Protein Description | Essential signaling protein which has a major role in many developmental processes. [PubMed: 3935325 Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination] | |
| Protein Sequence | MQSQRSRRRSRAPNTWICFWINKMHAVASLPASLPLLLLTLAFANLPNTVRGTDTALVAASCTSVGCQNGGTCVTQLNGKTYCACDSHYVGDYCEHRNPCNSMRCQNGGTCQVTFRNGRPGISCKCPLGFDESLCEIAVPNACDHVTCLNGGTCQLKTLEEYTCACANGYTGERCETKNLCASSPCRNGATCTALAGSSSFTCSCPPGFTGDTCSYDIEECQSNPCKYGGTCVNTHGSYQCMCPTGYTGKDCDTKYKPCSPSPCQNGGICRSNGLSYECKCPKGFEGKNCEQNYDDCLGHLCQNGGTCIDGISDYTCRCPPNFTGRFCQDDVDECAQRDHPVCQNGATCTNTHGSYSCICVNGWAGLDCSNNTDDCKQAACFYGATCIDGVGSFYCQCTKGKTGLLCHLDDACTSNPCHADAICDTSPINGSYACSCATGYKGVDCSEDIDECDQGSPCEHNGICVNTPGSYRCNCSQGFTGPRCETNINECESHPCQNEGSCLDDPGTFRCVCMPGFTGTQCEIDIDECQSNPCLNDGTCHDKINGFKCSCALGFTGARCQINIDDCQSQPCRNRGICHDSIAGYSCECPPGYTGTSCEININDCDSNPCHRGKCIDDVNSFKCLCDPGYTGYICQKQINECESNPCQFDGHCQDRVGSYYCQCQAGTSGKNCEVNVNECHSNPCNNGATCIDGINSYKCQCVPGFTGQHCEKNVDECISSPCANNGVCIDQVNGYKCECPRGFYDAHCLSDVDECASNPCVNEGRCEDGINEFICHCPPGYTGKRCELDIDECSSNPCQHGGTCYDKLNAFSCQCMPGYTGQKCETNIDDCVTNPCGNGGTCIDKVNGYKCVCKVPFTGRDCESKMDPCASNRCKNEAKCTPSSNFLDFSCTCKLGYTGRYCDEDIDECSLSSPCRNGASCLNVPGSYRCLCTKGYEGRDCAINTDDCASFPCQNGGTCLDGIGDYSCLCVDGFDGKHCETDINECLSQPCQNGATCSQYVNSYTCTCPLGFSGINCQTNDEDCTESSCLNGGSCIDGINGYNCSCLAGYSGANCQYKLNKCDSNPCLNGATCHEQNNEYTCHCPSGFTGKQCSEYVDWCGQSPCENGATCSQMKHQFSCKCSAGWTGKLCDVQTISCQDAADRKGLSLRQLCNNGTCKDYGNSHVCYCSQGYAGSYCQKEIDECQSQPCQNGGTCRDLIGAYECQCRQGFQGQNCELNIDDCAPNPCQNGGTCHDRVMNFSCSCPPGTMGIICEINKDDCKPGACHNNGSCIDRVGGFECVCQPGFVGARCEGDINECLSNPCSNAGTLDCVQLVNNYHCNCRPGHMGRHCEHKVDFCAQSPCQNGGNCNIRQSGHHCICNNGFYGKNCELSGQDCDSNPCRVGNCVVADEGFGYRCECPRGTLGEHCEIDTLDECSPNPCAQGAACEDLLGDYECLCPSKWKGKRCDIYDANYPGWNGGSGSGNDRYAADLEQQRAMCDKRGCTEKQGNGICDSDCNTYACNFDGNDCSLGINPWANCTANECWNKFKNGKCNEECNNAACHYDGHDCERKLKSCDSLFDAYCQKHYGDGFCDYGCNNAECSWDGLDCENKTQSPVLAEGAMSVVMLMNVEAFREIQAQFLRNMSHMLRTTVRLKKDALGHDIIINWKDNVRVPEIEDTDFARKNKILYTQQVHQTGIQIYLEIDNRKCTECFTHAVEAAEFLAATAAKHQLRNDFQIHSVRGIKNPGDEDNGEPPANVKYVITGIILVIIALAFFGMVLSTQRKRAHGVTWFPEGFRAPAAVMSRRRRDPHGQEMRNLNKQVAMQSQGVGQPGAHWSDDESDMPLPKRQRSDPVSGVGLGNNGGYASDHTMVSEYEEADQRVWSQAHLDVVDVRAIMTPPAHQDGGKHDVDARGPCGLTPLMIAAVRGGGLDTGEDIENNEDSTAQVISDLLAQGAELNATMDKTGETSLHLAARFARADAAKRLLDAGADANCQDNTGRTPLHAAVAADAMGVFQILLRNRATNLNARMHDGTTPLILAARLAIEGMVEDLITADADINAADNSGKTALHWAAAVNNTEAVNILLMHHANRDAQDDKDETPLFLAAREGSYEACKALLDNFANREITDHMDRLPRDVASERLHHDIVRLLDEHVPRSPQMLSMTPQAMIGSPPPGQQQPQLITQPTVISAGNGGNNGNGNASGKQSNQTAKQKAAKKAKLIEGSPDNGLDATGSLRRKASSKKTSAASKKAANLNGLNPGQLTGGVSGVPGVPPTNSAAQAAAAAAAAVAAMSHELEGSPVGVGMGGNLPSPYDTSSMYSNAMAAPLANGNPNTGAKQPPSYEDCIKNAQSMQSLQGNGLDMIKLDNYAYSMGSPFQQELLNGQGLGMNGNGQRNGVGPGVLPGGLCGMGGLSGAGNGNSHEQGLSPPYSNQSPPHSVQSSLALSPHAYLGSPSPAKSRPSLPTSPTHIQAMRHATQQKQFGGSNLNSLLGGANGGGVVGGGGGGGGGVGQGPQNSPVSLGIISPTGSDMGIMLAPPQSSKNSAIMQTISPQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQQLGGLEFGSAGLDLNGFCGSPDSFHSGQMNPPSIQSSMSGSSPSTNMLSPSSQHNQQAFYQYLTPSSQHSGGHTPQHLVQTLDSYPTPSPESPGHWSSSSPRSNSDWSEGVQSPAANNLYISGGHQANKGSEAIYI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 72 | O-linked_Glycosylation | VGCQNGGTCVTQLNG EECCCCCEEEEEECC | 12.76 | 27268051 | |
| 110 | O-linked_Glycosylation | MRCQNGGTCQVTFRN CCCCCCCEEEEEEEC | 10.93 | 27268051 | |
| 153 | O-linked_Glycosylation | VTCLNGGTCQLKTLE EEEECCCEEEEEEHH | 9.85 | 27268051 | |
| 171 | O-linked_Glycosylation | CACANGYTGERCETK EEECCCCCCCCCCCC | 33.68 | 27268051 | |
| 183 | O-linked_Glycosylation | ETKNLCASSPCRNGA CCCCCCCCCCCCCCC | 33.54 | 27268051 | |
| 191 | O-linked_Glycosylation | SPCRNGATCTALAGS CCCCCCCCCEEECCC | 16.28 | 27268051 | |
| 210 | O-linked_Glycosylation | CSCPPGFTGDTCSYD EECCCCCCCCCCCEE | 39.81 | 27268051 | |
| 223 | O-linked_Glycosylation | YDIEECQSNPCKYGG EEHHHHHCCCCCCCC | 55.16 | 27268051 | |
| 231 | O-linked_Glycosylation | NPCKYGGTCVNTHGS CCCCCCCEEEECCCC | 14.66 | 27268051 | |
| 248 | O-linked_Glycosylation | CMCPTGYTGKDCDTK EECCCCCCCCCCCCC | 38.82 | 27268051 | |
| 307 | O-linked_Glycosylation | HLCQNGGTCIDGISD HHHHCCCCEEECCCC | 14.00 | 27268051 | |
| 322 | N-linked_Glycosylation | YTCRCPPNFTGRFCQ CCCCCCCCCCCCCCC | 32.05 | - | |
| 348 | O-linked_Glycosylation | PVCQNGATCTNTHGS CCCCCCCEECCCCCC | 22.66 | 27268051 | |
| 371 | N-linked_Glycosylation | WAGLDCSNNTDDCKQ EEEEECCCCCCCHHH | 62.85 | - | |
| 386 | O-linked_Glycosylation | AACFYGATCIDGVGS HHHHHCCEEECCCCE | 12.96 | 27268051 | |
| 403 | O-linked_Glycosylation | CQCTKGKTGLLCHLD EEECCCCCEEEEECC | 41.55 | 27268051 | |
| 427 | O-linked_Glycosylation | ADAICDTSPINGSYA CCEEECCCCCCCCEE | 15.55 | 27268051 | |
| 430 | N-linked_Glycosylation | ICDTSPINGSYACSC EECCCCCCCCEECCC | 36.42 | - | |
| 475 | N-linked_Glycosylation | TPGSYRCNCSQGFTG CCCCEECCCCCCCCC | 21.34 | - | |
| 481 | O-linked_Glycosylation | CNCSQGFTGPRCETN CCCCCCCCCCCEECC | 53.77 | 27268051 | |
| 494 | O-linked_Glycosylation | TNINECESHPCQNEG CCCHHHHCCCCCCCC | 44.37 | 27268051 | |
| 502 | O-linked_Glycosylation | HPCQNEGSCLDDPGT CCCCCCCCCCCCCCC | 12.82 | 27268051 | |
| 519 | O-linked_Glycosylation | CVCMPGFTGTQCEID EEECCCCCCCEEEEE | 45.28 | 27268051 | |
| 532 | O-linked_Glycosylation | IDIDECQSNPCLNDG EEHHHHHCCCCCCCC | 55.16 | 27268051 | |
| 557 | O-linked_Glycosylation | CSCALGFTGARCQIN CEEEECCCCCCEEEE | 28.29 | 27268051 | |
| 570 | O-linked_Glycosylation | INIDDCQSQPCRNRG EECHHHHCCCCCCCC | 42.28 | 27268051 | |
| 595 | O-linked_Glycosylation | CECPPGYTGTSCEIN CCCCCCCCCCCEEEE | 39.64 | 27268051 | |
| 608 | O-linked_Glycosylation | ININDCDSNPCHRGK EEECCCCCCCCCCCC | 49.34 | 27268051 | |
| 632 | O-linked_Glycosylation | CLCDPGYTGYICQKQ EECCCCCCCEEEHHH | 29.44 | 27268051 | |
| 645 | O-linked_Glycosylation | KQINECESNPCQFDG HHHHCCCCCCCCCCC | 58.70 | 27268051 | |
| 670 | O-linked_Glycosylation | CQCQAGTSGKNCEVN EEEECCCCCCCCEEE | 47.02 | 27268051 | |
| 683 | O-linked_Glycosylation | VNVNECHSNPCNNGA EECCCCCCCCCCCCC | 54.87 | 27268051 | |
| 691 | O-linked_Glycosylation | NPCNNGATCIDGINS CCCCCCCCEECCCCC | 16.05 | 27268051 | |
| 708 | O-linked_Glycosylation | CQCVPGFTGQHCEKN CCCCCCCCCCCCCCC | 41.68 | 27268051 | |
| 721 | O-linked_Glycosylation | KNVDECISSPCANNG CCHHHHHCCCCCCCC | 39.63 | 27268051 | |
| 759 | O-linked_Glycosylation | SDVDECASNPCVNEG CCHHHHHCCCCCCCC | 53.62 | 27268051 | |
| 784 | O-linked_Glycosylation | CHCPPGYTGKRCELD ECCCCCCCCCCCEEC | 41.99 | 27268051 | |
| 797 | O-linked_Glycosylation | LDIDECSSNPCQHGG ECCHHHCCCCCCCCC | 57.35 | 27268051 | |
| 805 | O-linked_Glycosylation | NPCQHGGTCYDKLNA CCCCCCCCHHHHCCC | 16.69 | 27268051 | |
| 822 | O-linked_Glycosylation | CQCMPGYTGQKCETN CEECCCCCCCCCCCC | 38.77 | 27268051 | |
| 843 | O-linked_Glycosylation | NPCGNGGTCIDKVNG CCCCCCCCEEECCCC | 14.00 | 27268051 | |
| 900 | O-linked_Glycosylation | CTCKLGYTGRYCDED EEEECCCCCCCCCCC | 17.24 | 27268051 | |
| 922 | O-linked_Glycosylation | SPCRNGASCLNVPGS CCCCCCCCCCCCCCC | 22.12 | 27268051 | |
| 952 | O-linked_Glycosylation | INTDDCASFPCQNGG ECCCCCCCCCCCCCC | 35.73 | 27268051 | |
| 960 | O-linked_Glycosylation | FPCQNGGTCLDGIGD CCCCCCCEECCCCCC | 15.99 | 27268051 | |
| 990 | O-linked_Glycosylation | TDINECLSQPCQNGA CCHHHHHCCCCCCCC | 43.67 | 27268051 | |
| 998 | O-linked_Glycosylation | QPCQNGATCSQYVNS CCCCCCCCHHHHCCE | 24.45 | 27268051 | |
| 1015 | O-linked_Glycosylation | CTCPLGFSGINCQTN ECCCCCCCCCCCCCC | 36.64 | 27268051 | |
| 1036 | O-linked_Glycosylation | SSCLNGGSCIDGING CCCCCCCCCCCCCCC | 14.86 | 27268051 | |
| 1045 | N-linked_Glycosylation | IDGINGYNCSCLAGY CCCCCCCCCCEEECC | 16.78 | - | |
| 1053 | O-linked_Glycosylation | CSCLAGYSGANCQYK CCEEECCCCCCCEEE | 30.43 | 27268051 | |
| 1066 | O-linked_Glycosylation | YKLNKCDSNPCLNGA EEECCCCCCCCCCCC | 52.74 | 27268051 | |
| 1074 | O-linked_Glycosylation | NPCLNGATCHEQNNE CCCCCCCCCCCCCCE | 18.78 | 27268051 | |
| 1091 | O-linked_Glycosylation | CHCPSGFTGKQCSEY EECCCCCCCCCHHHC | 47.17 | 27268051 | |
| 1112 | O-linked_Glycosylation | SPCENGATCSQMKHQ CCCCCCCCHHHCCCE | 17.68 | 27268051 | |
| 1129 | O-linked_Glycosylation | CKCSAGWTGKLCDVQ CCCCCCCCCCCCCEE | 24.42 | 27268051 | |
| 1157 | N-linked_Glycosylation | SLRQLCNNGTCKDYG CHHHHHCCCCCCCCC | 46.27 | - | |
| 1189 | O-linked_Glycosylation | KEIDECQSQPCQNGG HHHHHHHCCCCCCCC | 47.99 | 27268051 | |
| 1197 | O-linked_Glycosylation | QPCQNGGTCRDLIGA CCCCCCCCHHHHHHH | 13.03 | 27268051 | |
| 1235 | O-linked_Glycosylation | NPCQNGGTCHDRVMN CCCCCCCCCCHHHEE | 14.20 | 27268051 | |
| 1242 | N-linked_Glycosylation | TCHDRVMNFSCSCPP CCCHHHEEEEECCCC | 23.87 | - | |
| 1271 | N-linked_Glycosylation | KPGACHNNGSCIDRV CCCCCCCCCCCCCCC | 21.79 | - | |
| 1273 | O-linked_Glycosylation | GACHNNGSCIDRVGG CCCCCCCCCCCCCCC | 15.26 | 27268051 | |
| 1303 | O-linked_Glycosylation | GDINECLSNPCSNAG CCHHHHHCCCCCCCC | 50.84 | 27268051 | |
| 1381 | O-linked_Glycosylation | LSGQDCDSNPCRVGN CCCCCCCCCCCCCCC | 49.34 | 27268051 | |
| 1521 | N-linked_Glycosylation | LGINPWANCTANECW CCCCCCCCCCHHHHH | 21.58 | - | |
| 1594 | N-linked_Glycosylation | WDGLDCENKTQSPVL CCCCCCCCCCCCCCH | 60.03 | - | |
| 1627 | N-linked_Glycosylation | IQAQFLRNMSHMLRT HHHHHHHHHHHHHHH | 38.16 | - | |
| 2447 | Phosphorylation | SPAKSRPSLPTSPTH CCCCCCCCCCCCHHH | 45.96 | 27268051 | |
| 2450 | Phosphorylation | KSRPSLPTSPTHIQA CCCCCCCCCHHHHHH | 53.27 | 21082442 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NOTCH_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NOTCH_DROME !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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