dbPTM

RHOM_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHOM_DROME
UniProt AC	P20350
Protein Name	Protein rhomboid
Gene Name	rho
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	355
Subcellular Localization	Golgi apparatus membrane Multi-pass membrane protein.
Protein Description	Acts early in embryonic development to establish position along the dorsoventral axis and then again later to specify the fate of neuronal precursor cells. Involved in EGF receptor signaling; cleaves Spitz to release the active growth factor..
Protein Sequence	MENLTQNVNETKVDLGQEKEKEASQEEEHATAAKETIIDIPAACSSSSNSSSYDTDCSTASSTCCTRQGEHIYMQREAIPATPLPESEDIGLLKYVHRQHWPWFILVISIIEIAIFAYDRYTMPAQNFGLPVPIPSDSVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFLVGASGGVYALLAAHLANITLNYAHMKSASTQLGSVVIFVSCDLGYALYTQYFDGSAFAKGPQVSYIAHLTGALAGLTIGFLVLKNFGHREYEQLIWWLALGVYCAFTVFAIVFNLINTVTAQLMEEQGEVITQHLLHDLGVS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of RHOM_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RHOM_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHOM_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHOM_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTCH_DROME	N	genetic	11904431
FAS2_DROME	Fas2	genetic	19141676
SOG_DROME	sog	genetic	9012523
STAR_DROME	S	genetic	10331978
STAR_DROME	S	genetic	7833286
STAR_DROME	S	genetic	9486793
STAR_DROME	S	genetic	11904431
POK_DROME	aop	genetic	7833286
DECA_DROME	dpp	genetic	9012523
DECA_DROME	dpp	genetic	9056776
HRS_DROME	Hrs	genetic	21878499
AFF4_DROME	lilli	genetic	16387886
GRK_DROME	grk	genetic	9486793
SOS_DROME	Sos	genetic	7833286
SPITZ_DROME	spi	genetic	7833286
SPITZ_DROME	spi	genetic	9814706
VPS25_DROME	Vps25	genetic	21878499
EGFR_DROME	Egfr	genetic	10331978
EGFR_DROME	Egfr	genetic	7833286
EGFR_DROME	Egfr	genetic	9570772
SRF_DROME	bs	genetic	7720583
SRF_DROME	bs	genetic	9550715
EMC_DROME	emc	genetic	10072780
SPY_DROME	sty	genetic	10089881
VEIN_DROME	vn	genetic	15084467
VEIN_DROME	vn	genetic	26963612
DCTN1_DROME	Gl	genetic	18653542
BRM_DROME	brm	genetic	15013794
GIL_DROME	aos	genetic	8026629
GIL_DROME	aos	genetic	15572130
PC_DROME	Pc	genetic	15013794
RAS1_DROME	Ras85D	genetic	7833286
ANXB9_DROME	AnxB9	genetic	21878499
HHAT_DROME	rasp	genetic	16459296
VPS28_DROME	Vps28	genetic	21878499
RHDF1_DROME	rho-5	genetic	21439629
GRK_DROME	grk	physical	12169630
GRK_DROME	grk	physical	12225666
SPITZ_DROME	spi	physical	11672524
SPITZ_DROME	spi	physical	11672525
SPITZ_DROME	spi	physical	12169630
SPITZ_DROME	spi	physical	12225666
SPITZ_DROME	spi	physical	12820957
SPITZ_DROME	spi	physical	15684070

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHOM_DROME

Related Literatures of Post-Translational Modification