SPY_DROME - dbPTM
SPY_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SPY_DROME
UniProt AC O44783
Protein Name Protein sprouty
Gene Name sty
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 589
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side .
Protein Description Inhibitor of tracheal branching that restricts branch budding by antagonizing the BNL-FGF pathway (BNL: branchless, an fgf inducer of branching). Acts as an antagonist of EGFR-mediated signaling in the eye (where it is important for cell determination) midline glia, chordotonal organs, wing and ovarian follicle cells..
Protein Sequence MDRRNGGDPLAPPRPPKLLPRVHRPRAPEPTLSGVDHNAGATASALASGASSAAPVAIHNNNSQQQLSISAAASNNNTISIIPASPDFDDYQIHHLTFLPQRPSSLSRNSSTASSTTATGISVSGSGSVSGSSSSFTRRRPPAPVPLNNSISNNNNNSINNNFLSHFQSAEPASNALGQPPASPVTLAQPRPESERLTNEYVDTPLQHATRSQHPAGQQDNGQTTTHHLLLLPQRNQHLHLQQHQQHLQQQQQQQQQQQQQQHLQHQQNQQHARLATTTQATSVGSDHTDGLLHSHLQNSTTKPPASKQPAPPRLGMGLGLGLGLGLNQPIITKQPTPATQKERMHALEELLQPGGAGGNGGPLVMAGDPSLLNPIVCPRCGRCRCEQCQSPRPLPQTWVCNKTCLCSAESVIDYASCLCCAKALFYHCARDNDLDCDDGNGTPCVDNPCSCGPYKRTQRWGWLGALSIFLPCLWFYWPMRGCMKLCEKCYGRFAGRGCRCQGIGGGGAGSGGGVGSIGSTSSMLPIVPLGVNGSGLGGGVSLSGGVTDGGLNQANGKAMDHGCSAARSILRKGDLTPEKRLLDSSPDY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
201PhosphorylationSERLTNEYVDTPLQH
HHHCCCCCCCCHHHH		13.0019429919
443PhosphorylationDCDDGNGTPCVDNPC
CCCCCCCCCCCCCCC		19.9522817900
451PhosphorylationPCVDNPCSCGPYKRT
CCCCCCCCCCCCHHH		24.3022817900
455PhosphorylationNPCSCGPYKRTQRWG
CCCCCCCCHHHCCCH		9.8222817900
577PhosphorylationILRKGDLTPEKRLLD
HHHHCCCCHHHHHHC		33.8619429919
585PhosphorylationPEKRLLDSSPDY---
HHHHHHCCCCCC---		43.6819429919
586PhosphorylationEKRLLDSSPDY----
HHHHHCCCCCC----		22.8119429919
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SPY_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SPY_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SPY_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CARM1_DROMEArt4physical
14605208
BTKL_DROMEBtk29Aphysical
15710747
NOTCH_DROMENphysical
15710747
ICCR_DROMErstphysical
15710747
DISC_DROMEdiscophysical
15710747
PPN_DROMEPpnphysical
15710747
SPIR_DROMEspirphysical
15710747
HERC2_DROMEHERC2physical
15710747
LAMA_DROMELanAphysical
15710747
LAMB1_DROMELanB1physical
15710747
LAMC1_DROMELanB2physical
15710747
SERR_DROMESerphysical
15710747
TPIS_DROMETpiphysical
15710747
APKC_DROMEaPKCphysical
15710747
Y2138_DROMECG32138physical
22036573
NEDD4_DROMENedd4physical
22036573
FAS2_DROMEFas2genetic
19141676
POK_DROMEaopgenetic
10226010
GAP1_DROMERasGAP1genetic
10226010
GIL_DROMEaosgenetic
21439629
SINA_DROMEsinagenetic
10226010
RAS1_DROMERas85Dgenetic
10226010
HRD1_DROMEsip3genetic
21439629
RHDF1_DROMErho-5genetic
21439629
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SPY_DROME

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Related Literatures of Post-Translational Modification

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