LAMB1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LAMB1_DROME
• UniProt AC: P11046
• Protein Name: Laminin subunit beta-1
• Gene Name: LanB1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1788
• Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane.
• Protein Description: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components..
• Protein Sequence: MLELRLIVVIVLALLSWQWDPVDSQRPPQHGRRDRPKYPPNKFIKTHPCERSSCYPATGNLLIGRENRLTASSTCGLHSPERFCILSHLQDKKCFLCDTREETKHDPYKNHRIGQIIYKTKPGTNIPTWWQSENGKENATIQLDLEAEFHFTHLIITFTTFRPAAMYIERSFDFGQTWHIYRYFAYDCKESFPGVPTVLENITDVMCTSRYSNVEPSRNGEVIFRVLPPNINVTDPYAEHVQNQLKMTNLRIQMTKLHKLGDNLLDSRLENEEKYYYGISNMVVRGSCSCYGHASQCLPLDPAFSQADNEDGMVHGRCECTHNTKGMNCEECEDFFNDLPWKPAFGKKTNACKKCECNDHAVSCHFDEAVFTASGFVSGGVCDNCLHNTRGQHCEECMPYFYRDPEQDITSERVCQPCDCDPQGSSDDGICDSLNELEEGAVAGACHCKAFVTGRRCNQCKDGYWNLQSDNPEGCEPCTCNPLGTLNNSGCVMRTGECKCKKYVTGKDCNQCMPETYGLSESPEGCSLCNCDAGGSYDNYCDVISGQCRCRPHMTGRSCSQPKQNYFIPLLPEVHEAEVVDECISYGANGNCSLVAETPDGSFTGIGFTRVPENSELVFTVGDIPRSMPYDAVIRYQSTSRGDWENAFITLVRPDQVDPEGGCGELAAATSSETRIPFSLPDRSRQVVALNEVCLEAGKVYKFRIYFERKRHDVDSPTATILVDSLTLIPRIDVTPIFQGSVLADIRKKDYEKYNCKSSLYDMNYKSDPKCQNLDNILSVFVHDGASMCNCNPTGSLSKVCESNGGYCQCKPNVVGRQCDQCAPGTYGFGPEGCKACDCNSIGSKDKYCDLITGQCQCVPNTYGRECNQCQPGYWNFPECRVCQCNGHAATCDPIQGTCIDCQDSTTGYSCDSCLDGYYGNPLFGSEIGCRPCRCPETVASGLAHADGCSLDTRNNNMLCHCQEGYSGSRCEICADNFFGNPDNGGTCSKCECSNNVDLYDTGNCDRQTGACLKCLYQTTGDHCELCKDGFFGDALQQNCQQCECDFLGTNNTIAHCDRFTGQCPCLPNVQGVRCDQCAENHWKIASGEGCESCNCDPIGALHEQCNSYTGQCQCKPGFGGRACNQCQAHYWGNPNEKCQPCECDQFGAADFQCDRETGNCVCHEGIGGYKCNECARGYIGQFPHCSPCGECFNNWDLILSALEDATTATILRAKEIKQVGATGAYTSEFSELDKKLQHIRNLLQNTSVSLVDIEKLDYETQSLRDQLQASHGRLSETEQNLDDIYNSLSLSGVELESLQNHSRLVQQLSKELKENGIQLQESNIEGALNLTRHAYERVSNLSTLKDEANELASNTDRNCKRVENLSNKIQAEADDLANNNKLIEDYRAELTSLTSQIPELNNQVCGKPGDPCDSLCGGAGCGHCGGFLSCEHGAKTHSEEALKVAKDAETAITSKKDQADQTIRALTQAKLNASEAYEKAKRGFEQSERYLNQTNANIKLAENLFIALNNFQENKTASPSESKELAQKTLDLDLKLEPEEIETLGDQINRAVSSLKNVEAIIYRTKPDLDRVNNLQSIANATKEKADKILDSANSVVESLAAADESQGKAKDAIQQANSNIELAGQDLEKIDEETYSAEAPANNTAQQVEKLAKKVQKLQNNIMKNDRDAKEITKEAGSVKLEAMRARGEANNLQSATSATNQTLTDRASRSENARERAKQLLQRASKLTVDTNAKLKDLNDLQTVYLNKNQQLLRLQAEIGPLNKELNEHLIHIKERGSHYRQCYT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
138	N-linked_Glycosylation	QSENGKENATIQLDL ECCCCCCCEEEEEEE	45.96	-
201	N-linked_Glycosylation	GVPTVLENITDVMCT CCCCHHHHHCHHHCC	38.00	-
232	N-linked_Glycosylation	RVLPPNINVTDPYAE EECCCCCCCCCHHHH	36.96	-
267	Phosphorylation	LGDNLLDSRLENEEK HCCCHHHHHCCCCCC	38.44	27794539
487	N-linked_Glycosylation	CNPLGTLNNSGCVMR CCCCCCCCCCCCEEE	40.22	-
591	N-linked_Glycosylation	ISYGANGNCSLVAET HHCCCCCCEEEEEEC	16.41	-
1051	N-linked_Glycosylation	ECDFLGTNNTIAHCD CCCCCCCCCCEEEEC	41.68	-
1246	N-linked_Glycosylation	HIRNLLQNTSVSLVD HHHHHHHCCCEEEEE	34.00	-
1301	N-linked_Glycosylation	VELESLQNHSRLVQQ CCHHHHHHHHHHHHH	40.16	-
1330	N-linked_Glycosylation	SNIEGALNLTRHAYE HCHHHHHHHHHHHHH	38.54	-
1341	N-linked_Glycosylation	HAYERVSNLSTLKDE HHHHHHHCHHHHHHH	34.84	-
1473	N-linked_Glycosylation	ALTQAKLNASEAYEK HHHHHHCCHHHHHHH	40.49	-
1493	N-linked_Glycosylation	EQSERYLNQTNANIK HHHHHHHHHCCCCHH	37.38	17893096
1515	N-linked_Glycosylation	ALNNFQENKTASPSE HHHCCCCCCCCCHHH	35.87	-
1581	N-linked_Glycosylation	NNLQSIANATKEKAD HCHHHHHHHCHHHHH	46.61	-
1644	N-linked_Glycosylation	YSAEAPANNTAQQVE CCCCCCCCCHHHHHH	45.38	-
1703	N-linked_Glycosylation	QSATSATNQTLTDRA HHHHHHHHHHHHHHH	32.34	-
1746	Phosphorylation	KDLNDLQTVYLNKNQ CCCHHCEEEEECCCH	20.58	22668510
1748	Phosphorylation	LNDLQTVYLNKNQQL CHHCEEEEECCCHHH	14.14	22668510

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LAMB1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LAMB1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LAMB1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WWOX_DROME	Wwox	physical	14605208
LAMC1_DROME	LanB2	physical	22036573

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Identification of N-glycosylated proteins from the central nervoussystem of Drosophila melanogaster.";
Koles K., Lim J.-M., Aoki K., Porterfield M., Tiemeyer M., Wells L.,Panin V.;
Glycobiology 17:1388-1403(2007).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1493, AND MASSSPECTROMETRY.
PubMed: 17893096