BTKL_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTKL_DROME
• UniProt AC: P08630
• Protein Name: Tyrosine-protein kinase Btk29A
• Gene Name: Btk29A
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 786
• Subcellular Localization: Ring canals.
• Protein Description: Required for proper ring canal development. Also required for the development of male genitalia and for adult survival..
• Protein Sequence: MMGTKHRNSHVNGSIKSSSSLRSSSKSFQAKMDLMSERLYDVVKSGSMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTPKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVVALYPFKAIEGGDLSLEKNAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSEKHCCETIPDLINYHRHNSGGLACRLKSSPCDRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQTLTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
677	Phosphorylation	RYVLDDQYTSSGGTK EEECCCCCCCCCCCC	18.65	14976559

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
677	Y	Phosphorylation	Kinase	SRC64B	P00528	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTKL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTKL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PROF_DROME	chic	genetic	16000381
CCNE_DROME	CycE	genetic	16000381
SRC42_DROME	Src42A	genetic	10634792
SRC42_DROME	Src42A	genetic	16000381
3BP5H_DROME	pcs	genetic	16023106
3BP5H_DROME	pcs	genetic	25803041
CADF_DROME	tsr	genetic	16000381
SRC64_DROME	Src64B	genetic	16000381

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.