3BP5H_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: 3BP5H_DROME
• UniProt AC: Q9V785
• Protein Name: SH3 domain-binding protein 5 homolog
• Gene Name: pcs
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 477
• Protein Sequence: MSSAEDGELDPQIQIELENLNSATDEINKLEIELEEANSTFRILLNESTRRLKVSSKKLGNCIEKARPYYEALDKAREAQIECQKAAVKFQRANEIHAAAKETVALAEQRFMSNSHEWQFDNAWQEMLNHATQKVMDAETQKADCHAEHQRLTKLFNAAEQKLQQLEDRFRRSINKSRPYFEEKQVCQDQLQTQKNRIQELQQQVAGAKSTYSTALRNLERISEDIHRQRGDFPTPPGPREPGVGAELNSPTSSALPSLPDFQLELEKCDYPSIAGSQMSLGAKTPQAAAETEDEEDACDYDETGAGELRGVVDERDLEALRQKVKILAVRPIEGGDGQQQNDVWEHELKATVDKLDHLMMLKETAKRQQTNRLKSTEQRPDSLGAEALKRHCDVVEVKVTSCATTASLPVTPHHQLNHLAPPTPIKKLQQQLAPLPSVNVSMRELPLLARLSNELLDRSSAAFGGVRKTLRRRSLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Phosphorylation	ALAEQRFMSNSHEWQ HHHHHHHHCCCCHHH	3.95	18327897
113	Phosphorylation	LAEQRFMSNSHEWQF HHHHHHHCCCCHHHH	32.25	18327897
114	Phosphorylation	AEQRFMSNSHEWQFD HHHHHHCCCCHHHHH	35.28	18327897
115	Phosphorylation	EQRFMSNSHEWQFDN HHHHHCCCCHHHHHH	18.57	18327897
250	Phosphorylation	GVGAELNSPTSSALP CCCCCCCCCCCCCCC	42.03	19429919
252	Phosphorylation	GAELNSPTSSALPSL CCCCCCCCCCCCCCC	34.82	19429919
253	Phosphorylation	AELNSPTSSALPSLP CCCCCCCCCCCCCCC	19.59	19429919
254	Phosphorylation	ELNSPTSSALPSLPD CCCCCCCCCCCCCCC	35.98	19429919
258	Phosphorylation	PTSSALPSLPDFQLE CCCCCCCCCCCHHHH	54.08	19429919
383	Phosphorylation	STEQRPDSLGAEALK CCCCCCCCHHHHHHH	31.24	19429919
453	Phosphorylation	LPLLARLSNELLDRS HHHHHHHHHHHHHHH	23.78	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of 3BP5H_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of 3BP5H_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of 3BP5H_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBB1_DROME	betaTub56D	physical	14605208
EYA_DROME	eya	physical	14605208
BTKL_DROME	Btk29A	genetic	12091316
BTKL_DROME	Btk29A	genetic	16987509
BTKL_DROME	Btk29A	genetic	25803041

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113 AND SER-115, ANDMASS SPECTROMETRY.
PubMed: 18327897