TBB1_DROME - dbPTM
TBB1_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBB1_DROME
UniProt AC Q24560
Protein Name Tubulin beta-1 chain
Gene Name betaTub56D
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 447
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)..
Protein Sequence MREIVHIQAGQCGNQIGAKFWEIISDEHGIDATGAYHGDSDLQLERINVYYNEASGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTYSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNIQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQEATADEDAEFEEEQEAEVDEN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
40PhosphorylationTGAYHGDSDLQLERI
CCCCCCCCCCEEEEE
44.8318327897
58AcetylationYNEASGGKYVPRAVL
EECCCCCCEECEEEE
46.7521791702
115PhosphorylationEGAELVDSVLDVVRK
CHHHHHHHHHHHHHH
19.6618327897
274PhosphorylationMPGFAPLTSRGSQQY
CCCCCCCCCCCCHHH
18.4719429919
275PhosphorylationPGFAPLTSRGSQQYR
CCCCCCCCCCCHHHE
42.1819429919
278PhosphorylationAPLTSRGSQQYRALT
CCCCCCCCHHHEEEE
17.0119429919
281PhosphorylationTSRGSQQYRALTVPE
CCCCCHHHEEEEHHH
7.1019429919
312PhosphorylationPRHGRYLTVAAIFRG
CCCCCCHHHHHHHCC
10.1221082442
322PhosphorylationAIFRGRMSMKEVDEQ
HHHCCCCCHHHHHHH
25.9121082442
338PhosphorylationLNIQNKNSSYFVEWI
HHCCCCCCCHHEEEC
28.2021082442
339PhosphorylationNIQNKNSSYFVEWIP
HCCCCCCCHHEEECC
31.8021082442
366PhosphorylationRGLKMSATFIGNSTA
CCCCEEEEECCCHHH
14.4221082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBB1_DROME !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBB1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBB1_DROME !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDKAL_DROMECG6550physical
22036573
C4AC1_DROMECyp4ac1physical
22036573
RS27A_DROMERpS27Aphysical
24292889
PFD3_DROMEmgrphysical
22451918
PFD2_DROMEl(3)01239physical
27025979
VHL_DROMEVhlphysical
20388653
VHL_DROMEVhlphysical
22451918

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBB1_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40 AND SER-339, AND MASSSPECTROMETRY.

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