dbPTM

PFD3_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PFD3_DROME
UniProt AC	Q9VGP6
Protein Name	Prefoldin subunit 3
Gene Name	mgr
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	194
Subcellular Localization	Cytoplasm .
Protein Description	Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for tubulin stability and spindle and centrosome formation in cooperation with Vhl..
Protein Sequence	MTGIMDSVEMPKLPENQKTFAGIPEAVFLEEIDTFMSQPENENCEKVLQRLDEQHGKYRFMACNLEARRRKLKSQIPDLERSLEMVNVLRKEDEERETQFLLSDQVFIKTLVPPTKTVYLWLGASVMLEYPLDEAEALLNQNITSAVGNLKSVEHDQDFLRDQITTTEVNMARVYNWGVKKRQAATKTTATTPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of PFD3_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PFD3_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PFD3_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PFD3_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSMD4_DROME	Rpn10	physical	14605208
EF1A1_DROME	Ef1alpha48D	physical	14605208
MED13_DROME	skd	physical	14605208
PFD5_DROME	CG7048	physical	22036573
TBB1_DROME	betaTub56D	genetic	22451918
PFD2_DROME	l(3)01239	genetic	27025979
TBB1_DROME	betaTub56D	physical	22451918
PFD3_DROME	mgr	physical	22451918
PFD2_DROME	l(3)01239	physical	27025979
VHL_DROME	Vhl	physical	22451918

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PFD3_DROME

Related Literatures of Post-Translational Modification