EF1A1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EF1A1_DROME
• UniProt AC: P08736
• Protein Name: Elongation factor 1-alpha 1 {ECO:0000312|FlyBase:FBgn0284245}
• Gene Name: eEF1alpha1 {ECO:0000312|FlyBase:FBgn0284245}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 463
• Subcellular Localization: Cytoplasm.
• Protein Description: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis..
• Protein Sequence: MGKEKIHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFETAKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGTGEFEAGISKNGQTREHALLAFTLGVKQLIVGVNKMDSSEPPYSEARYEEIKKEVSSYIKKIGYNPAAVAFVPISGWHGDNMLEPSTNMPWFKGWKVERKEGNADGKTLIDALDAILPPARPTDKALRLPLQDVYKIGGIGTVPVGRVETGVLKPGTVVVFAPANITTEVKSVEMHHEALQEAVPGDNVGFNVKNVSVKELRRGYVAGDSKANPPKGAADFTAQVIVLNHPGQIANGYTPVLDCHTAHIACKFAEIKEKVDRRSGKTTEENPKFIKSGDAAIVNLVPSKPLCVEAFQEFPPLGRFAVRDMRQTVAVGVIKAVNFKDASGGKVTKAAEKATKGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	VDSGKSTTTGHLIYK CCCCCCCCCCEEEEE	37.56	27794539
29	Phosphorylation	TTTGHLIYKCGGIDK CCCCEEEEECCCCCH	13.44	19429919
30	Acetylation	TTGHLIYKCGGIDKR CCCEEEEECCCCCHH	21.29	19608861
41	Acetylation	IDKRTIEKFEKEAQE CCHHHHHHHHHHHHH	55.78	19608861
44	Acetylation	RTIEKFEKEAQEMGK HHHHHHHHHHHHCCC	62.57	19608861
55	Acetylation	EMGKGSFKYAWVLDK HCCCCCHHHHHHHHH	35.44	19608861
172	Acetylation	ARYEEIKKEVSSYIK HHHHHHHHHHHHHHH	69.84	19608861
255	Acetylation	LPLQDVYKIGGIGTV CCHHHEEEECCCEEE	34.42	19608861
269	Phosphorylation	VPVGRVETGVLKPGT EECCEEECCCCCCCE	29.72	21082442
276	Phosphorylation	TGVLKPGTVVVFAPA CCCCCCCEEEEEECC	20.75	21082442
286	Phosphorylation	VFAPANITTEVKSVE EEECCCCCCEEEEEH	19.40	21082442
301	5-glutamyl glycerylphosphorylethanolamine	MHHEALQEAVPGDNV HHHHHHHHHCCCCCC	53.11	-
301	Formation of an isopeptide bond	MHHEALQEAVPGDNV HHHHHHHHHCCCCCC	53.11	8500545
330	Acetylation	GYVAGDSKANPPKGA CCCCCCCCCCCCCCC	57.85	21791702
374	5-glutamyl glycerylphosphorylethanolamine	HIACKFAEIKEKVDR HHHHHHHHHHHHHHH	58.70	-
374	Formation of an isopeptide bond	HIACKFAEIKEKVDR HHHHHHHHHHHHHHH	58.70	-
383	Phosphorylation	KEKVDRRSGKTTEEN HHHHHHCCCCCCCCC	45.60	25749252
386	Phosphorylation	VDRRSGKTTEENPKF HHHCCCCCCCCCCCE	42.86	21082442
392	Acetylation	KTTEENPKFIKSGDA CCCCCCCCEEECCCE	71.89	21791702
395	Acetylation	EENPKFIKSGDAAIV CCCCCEEECCCEEEE	52.06	21791702
432	Phosphorylation	AVRDMRQTVAVGVIK HHHCHHHHHEEEEEE	10.48	18511481
439	Ubiquitination	TVAVGVIKAVNFKDA HHEEEEEEECCCCCC	43.82	31113955
444	Acetylation	VIKAVNFKDASGGKV EEEECCCCCCCCCCC	47.37	21791702
447	Phosphorylation	AVNFKDASGGKVTKA ECCCCCCCCCCCCHH	59.20	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EF1A1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EF1A1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EF1A1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F206_DROME	CG9288	physical	14605208

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.