dbPTM

CDKAL_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDKAL_DROME
UniProt AC	Q7K4W1
Protein Name	Threonylcarbamoyladenosine tRNA methylthiotransferase
Gene Name	CG6550
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	552
Subcellular Localization	Membrane Single-pass membrane protein .
Protein Description	Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine..
Protein Sequence	MYHLGQDLPGNDVDDIEDLISADDVKPRERYENKKTVTVRAKKRSQIRLESQEEEEKPKPTIHESVIPGTQKVFVKTWGCAHNNSDSEYMAGQLAAYGYRLSGKEEADLWLLNSCTVKNPSEDTFRNEIESGMRNGKHVVVAGCVPQGAPKSDYLNGLSVIGVQQIDRVVEVVEETLKGHSVQLLQNKKKVHGRRVAGAPLSLPKVRKNPLIEIISINSGCLNQCTYCKTKHARGDLASYPPEEVVERARQSFAEGCCEIWLTSEDTGAYGRDIGSSLPELLWQLVEVIPEHCMLRVGMTNPPYILEHLEEVANVLQHPRVYSFLHVPVQSGSDSVLGEMKREYCRQDFEHVVDFLRERVPGVTIATDIICGFPTETEDDFEETMTLCAKYRFPSLFINQFFPRPGTPAAKMDRIPANLVKKRTKRLTDLFYSYEPYADRVGEIYTVLVTEVSHDKLHYVGHNKSYEQVLLPMRDNLLGTRVHVRITSASKFSMVGEILDDERDWTRCAKNQELPNVQVQTRSRERLIQRYFGIALVLGSLAFLIQLVVRLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
51	Phosphorylation	RSQIRLESQEEEEKP HHHEECCCCCCCCCC	47.70	22817900
61	Phosphorylation	EEEKPKPTIHESVIP CCCCCCCCCCHHHCC	40.88	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CDKAL_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDKAL_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDKAL_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CDKAL_DROME !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDKAL_DROME

Related Literatures of Post-Translational Modification