CCNE_DROME - dbPTM
CCNE_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CCNE_DROME
UniProt AC P54733
Protein Name G1/S-specific cyclin-E
Gene Name CycE
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 709
Subcellular Localization Nucleus .
Protein Description Essential for the control of the cell cycle at the G1/S (start) transition. Targeted by archipelago for degradation by the SFC ubiquitin ligase complex..
Protein Sequence MGLNAKSVCSTSSTEPNGSIVTTAPSNGEVSSSIVVVVSSSSISSSSDSPIAILPHPDPIPSTSFSSASQRSEEELPGTSAASRTDEMCSCDSQNLAASTAATSNGNKRKRRLSSDSNEDPELGFEPPSAKRQQRLPALYGSEQGNLSSVASSVYTSPVVSVDGQSTQELLSIRSSPAEDLSEAPHSPLPDSPDSPPSPDRGSKQTPVVVRYAAEQVVTSTVVTQKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNGERTPGLPKHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRDEQDSRLRSISMLEQHPGLQPRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSGLDWQVIQPCARWMEPFFRVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRARIQASPATALRAPESLLTPPASSHKPDEYLGDEGDETGARSGISSTTTCCNTAASNKGGKSSSNNSVTSCSSRSNP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
72PhosphorylationFSSASQRSEEELPGT
CCCHHHCCHHHCCCC		41.5429892262
114PhosphorylationNKRKRRLSSDSNEDP
CHHCCCCCCCCCCCC		30.2222817900
115PhosphorylationKRKRRLSSDSNEDPE
HHCCCCCCCCCCCCC		50.0422817900
117PhosphorylationKRRLSSDSNEDPELG
CCCCCCCCCCCCCCC		44.0325749252
129PhosphorylationELGFEPPSAKRQQRL
CCCCCCCCHHHHHCC		58.0822817900
161PhosphorylationVYTSPVVSVDGQSTQ
CCCCCEEEECCCCHH		18.0930478224
187PhosphorylationDLSEAPHSPLPDSPD
HHHCCCCCCCCCCCC		27.3722817900
192PhosphorylationPHSPLPDSPDSPPSP
CCCCCCCCCCCCCCC		28.7718327897
195PhosphorylationPLPDSPDSPPSPDRG
CCCCCCCCCCCCCCC		41.9422817900
198PhosphorylationDSPDSPPSPDRGSKQ
CCCCCCCCCCCCCCC		42.7022817900
206PhosphorylationPDRGSKQTPVVVRYA
CCCCCCCCCEEHEEE		23.0622817900
308PhosphorylationINMRTPMSPAVENGL
HHCCCCCCHHHHCCC		15.7727626673
638PhosphorylationMRARIQASPATALRA
HHHHHHCCHHHHHCC		9.9321082442
651PhosphorylationRAPESLLTPPASSHK
CCCHHHCCCCHHHCC		32.30-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CCNE_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CCNE_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CCNE_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GLEC_DROMEglecphysical
14605208
FBXW7_DROMEagogenetic
11565033
BRM_DROMEbrmphysical
12093739
RBF_DROMERbfgenetic
15454540
DLG1_DROMEdlg1genetic
15454540
BAP60_DROMEBap60genetic
15454540
RS6_DROMERpS6genetic
15454540
TTKB_DROMEttkgenetic
15454540
TTKA_DROMEttkgenetic
15454540
LAP4_DROMEscribgenetic
15454540
HYD_DROMEhydgenetic
15454540
ABL_DROMEAblgenetic
15454540
SINA_DROMEsinagenetic
15454540
BRM_DROMEbrmgenetic
15454540
FBXW7_DROMEagogenetic
15454540
SPY_DROMEstygenetic
15454540
EMC_DROMEemcgenetic
15454540
RAS3_DROMERgenetic
15454540
RFC2_DROMERfC4genetic
15454540
PRI1_DROMEDNApol-alpha50genetic
15454540
DALY_DROMEdallygenetic
15454540
PRI2_DROMEDNApol-alpha60genetic
15454540
E2F1_DROMEE2fgenetic
15454540
CRB_DROMEcrbgenetic
15454540
MPIP_DROMEstggenetic
15454540
HH_DROMEhhgenetic
15454540
RHO1_DROMERho1genetic
15454540
DRK_DROMEdrkgenetic
15454540
RAS1_DROMERas85Dgenetic
15454540
AXN_DROMEAxngenetic
15454540
DSH_DROMEdshgenetic
15454540
ARM_DROMEarmgenetic
15454540
WNTG_DROMEwggenetic
15454540
PNT1_DROMEpntgenetic
15454540
PNT2_DROMEpntgenetic
15454540
EGFR_DROMEEgfrgenetic
15454540
GAP1_DROMERasGAP1genetic
15454540
PTC_DROMEptcgenetic
15454540
CADE_DROMEshggenetic
15454540
EXPA_DROMEexgenetic
15454540
FAT_DROMEftgenetic
15454540
JAK_DROMEhopgenetic
15454540
L2GL_DROMEl(2)glgenetic
15454540
PHYL_DROMEphylgenetic
15454540
ITA3_DROMEscbgenetic
15454540
CADN_DROMECadNgenetic
15454540
GAGA_DROMETrlgenetic
15454540
CDK2_DROMEcdc2cphysical
11027291
ENC_DROMEencphysical
14623823
RBF_DROMERbfgenetic
9691043
RUX_DROMEruxgenetic
9691043
RUX_DROMEruxgenetic
15454540
RS6_DROMERpS6genetic
22194697
DECA_DROMEdppgenetic
9811590
KDM5_DROMElidgenetic
12093739
SPITZ_DROMEspigenetic
17055987
TFDP_DROMEDpgenetic
9691043
ITA3_DROMEscbgenetic
10790398
HIPPO_DROMEhpogenetic
12941273
CADE_DROMEshggenetic
19966222
EGFR_DROMEEgfrgenetic
17055987
CCNA_DROMECycAgenetic
9691043
RS12_DROMERpS12genetic
22194697
FGFR2_DROMEbtlgenetic
12093739
BRM_DROMEbrmgenetic
12093739
HID_DROMEWgenetic
17055987
ASH1_DROMEash1genetic
12093739
PC_DROMEPcgenetic
12093739
SCR_DROMEScrgenetic
12093739
RAS1_DROMERas85Dgenetic
17055987
HTH_DROMEhthgenetic
12093739
NSF2_DROMENsf2genetic
12093739
TRX_DROMEtrxgenetic
12093739
HSP7D_DROMEHsc70-4genetic
12093739
CSN5_DROMECSN5genetic
12737805
OSA_DROMEosagenetic
12093739
OSA_DROMEosagenetic
15454540
CDK2_DROMEcdc2cgenetic
9691043
CDK2_DROMEcdc2cgenetic
10790398
E2F1_DROMEE2fgenetic
9691043
E2F1_DROMEE2fgenetic
10790398
RS19B_DROMERpS19bgenetic
22194697
ASH2_DROMEash2genetic
12093739
MPIP_DROMEstggenetic
9691043
MED13_DROMEskdgenetic
12093739
SPEN_DROMEspengenetic
10790398
SPEN_DROMEspengenetic
15454540
MED12_DROMEktogenetic
12093739
MMD4_DROMEmod(mdg4)genetic
12093739
GAGA_DROMETrlgenetic
12093739
RL38_DROMERpL38genetic
22194697
CAUP_DROMEcaupphysical
26305360
PROS_DROMEprosphysical
19914234
CDK2_DROMEcdc2cphysical
8156587
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CCNE_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-115; SER-117;SER-129; SER-187; SER-192; SER-195 AND SER-198, AND MASS SPECTROMETRY.

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