FAT_DROME - dbPTM
FAT_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FAT_DROME
UniProt AC P33450
Protein Name Cadherin-related tumor suppressor
Gene Name ft {ECO:0000312|FlyBase:FBgn0001075}
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 5147
Subcellular Localization Cell membrane
Single-pass type I membrane protein. Apical cell membrane .
Ft-mito: Mitochondrion .
Protein Description Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells. [PubMed: 11893338 This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor]
Protein Sequence MERLLLLFFLLLAGRESLCQTGDTKLELLAPRGRSYATTYEQYAAFPRRRSSSSSPSGEMQSRAVDTSADFEVLEGQPRGTTVGFIPTKPKFSYRFNEPPREFTLDPVTGEVKTNVVLDREGMRDHYDLVVLSSQPTYPIEVRIKVLDVNDNSPEFPEPSIAISFSESATSGTRLLLDAATDADVGENGVTDQYEIVAGNVDNKFRLVTTANPSGDTSYLHLETTGNLDRESRGSYQLNISARDGGSPPRFGYLQVNVTILDVNDNPPIFDHSDYNVSLNETALPGTPVVTVMASDNDLGDNSKITYYLAETEHQFTVNPETGVISTTERVNCPQQTNVKSSASQKSCVFTVFARDHGSPRQDGRTYVTVNLLDTNDHDPIISFRFFPDGGKVATVDENAVNGTVVAAVAVKDSDSGLNGRTSVRIVSGNELGHFRLEEAADLHIVRVNGVLDREEIGKYNLTVVAMDQGTPARTTTAHLIIDVNDVNDHEPVFEKSEYSAVLSELAPTGSFVASITATDEDTGVNAQVHYDILSGNELKWFSMDPLTGLIVTTGPLDREIRDTVELSISARDGGPNPKFAYTQLKVIILDENDEAPQFSQREQNVTLGEDAPPQTIVALMTATDHDQGTNGSVTFALAPSVERLYPLQFALDALTGQLTTRRPLDREKMSQYEISVIARDQGAPTPQSATATVWLNVADVNDNDPQFYPRHYIYSLADDDDDIKLKKEVEKERILLHVTASDKDDGDNALIEYRLESGGEGLFQLDARSGAISLRGDAPASMHWKPHYKLLVSARDAGQRRSQQDAIVEIVLKSKLEMLECGQAQAGGYEFQMVEDHEQQRNSQPNREVGIVQVKSTNGKANSHIEYDIIQGDRAQNFRIDTRSGRITTARPLDREEQANYRLTILASSSSSSSAAASSVSYGQCIVNIAIIDLNDNAPVFALDRESEPTISLPENAAVGQEIYLSRVRDRDAGVNSRISYSLTNNPNQQFRIGPVTGVLYLQRPIRAEPGSLIHVELMATDAGSPPLSSKLSLSVLIADVNDHTPVFDHTSYETSLPETTKVNTRFFALAATDIDLGDNGRISYEIIEGNTERMFGVFPDGYLFVRAPLDREERDYYALTVSCRDAGQPSRSSVVPVVIHVIDENDNAPQFTNSTFTFSIPENAPADTFVGKLTAVDRDIGRNAELSFTLSSQTQDFTIDTRNGFIKTLRPFDREALVKVSRNAEASGEDGSLRGSMAGNYMLLEATVSDNGIPRLQDKVKVKVIVTDVNDNAPEFLRAPYHVTISEGASEGTHITHVFTQDADEGLNGDVYYSLAKGNEAGQFNLDSATGQLSLGRRLDRESQEIHHLIVVAKDAALKHPLSSNASITIVVLDENDNAPEFTQSSSEVSVLETSPTGTELMRFRASDADQGVNSQVVFSISAGNRRDTFHIDSITGSLYLHKPLDYEDITSYTLNITASDCGTPSLSTTVLYNVLVVDDNDNPPIFPSTAIVRQIKEGIPLKTPIVTVTADDPDSGLNGKVSYAISKQEPQLPQGRHFGINTETGVIHTLREIDRESIDTFRLTVVATDRAQPSERQLSTEKLVTVIVEDINDNAPVFVSMNAAILPPKFSTSKGSSTAVMQVHAKDADSSSNGLVTYEIVSGPQELFKLQRNTGIITFTPGPQFKQEVRYQLTLKSTDEAVQSERRSSEVYITIITPGSGGSESSVPQFEQRSKLSGSVYENEPIGTSILTVTAHLASAEIEYFVTNVTATGSRGQVDRLFDIDAKLGILSTAAELDREAGPEEYEVEVYAIALGGQPRTSRTKVRVTVLDKNDSPPQFLDTPFVYNVSEDLQIGHTISTLRAHDPDTLGSVTFLLMDGHDGKFLLEPSTGKLILNDTLDRETKSKYELRIRVSDGVQYTEAYATIQVSDTNDNPPLFEDTVYSFDIPENAQRGYQVGQIVARDADLGQNAQLSYGVVSDWANDVFSLNPQTGMLTLTARLDYEEVQHYILIVQAQDNGQPSLSTTITVYCNVLDLNDNAPIFDPMSYSSEVFENVPIATEVVTVSAKDIDSGNNGLIEYSITAGDVDSEFGIDSNGTIRTRRNLDREHRSTYTLTVTARDCADEFASFSELEETQLKLKYRSPRKYQQTRQEFLAHQKQQRLSSTVKVTILIKDVNDEVPVFISANETAIMENVAINTVVIAVKAVDNDEGRNGYIDYLMKEARDEDMGQSDPLPFSLNPTDGQLRVVDALDRELRSSYLLNITARDRGEPPQSTESQLLIRILDENDNSPVFDPKQYSASVAENASIGAMVLQVSATDVDEGANGRIRYSIVLGDQNHDFSISEDTGVVRVAKNLNYERLSRYSLTVRAEDCALENPAGDTAELTINILDINDNRPTFLDSPYLARVMENTVPPNGGYVLTVNAYDADTPPLNSQVRYFLKEGDSDLFRINASSGDIALLKPLDREQQSEYTLTLVAMDTGSPPLTGTGIVRVEVQDINDNDPVFELQSYHATVRENLPSGTHVLTPRATDKDEGLNAKLRFNLLGEHMHRFHIDSETGEISTATTLDREETSVYHLTLMAQDSSITEPRASSVNLTISVSDVNDNIPKFDSTTYNVAVPERISKGEFVFGARALDLDDGENAVVHYTISGRDQHYFDINTKTGVVSTKLELKTKTKSHDDLTYTIVISAMDQGEQSLSSKAELTVILRPPELFPTFAYMANSHFAMSEDVRPGKMITKVSATSPKKGLVGKIRYAIAGGIMGDSLRVDPNSGLLSVGQDGLDYELTHLYEIWIEAADGDTPSLRSVTLITLNVTDANDNAPVMEQLIYNAEVLEEESPPQLIAVVKASDRDSGDNGNVIYRLQNDFDGTFEITESGEIYTRMRLDREEIGDYAFVVEAVDQGVPHMTGTASVLLHLLDKNDNPPKFTRLFSLNVTENAEIGSFVIRVTSSDLDLGANANASYSFSENPGEKFRIEPQSGNITVAGHLDREQQDEYILKVVASDGAWRAETPITITIQDQNDNAPEFEHSFYSFSFPELQQSIALVGQIIATDRDKQGPNSVISYSLQQPSPMFSIDPATGEVFSKKAVRFKHSQYVRSPENMYALTVLATDNGKPPLYSECLVNINIVDAHNNPPKFEQAEYLAPLPQDAVRGQRIVRVHANDKQDLGTNEMDYSLMTFNLSSIFSVGRHDGWITLVKPIQVPPNTRYELVVRATDRGVPPQSDETRVVIVVTGENMDTPRFSVNSYQVIVPENEPVGSTILTVGATDDDTGPNGMLRYSISGGNERQDFSVDERTGGIVIQQQLDYDLIQEYHLNITVQDLGYHPLSSVAMLTIILTDVNDNPPVFNHKEYHCYIPENKPVGTFVFQAHAADKDSPKNAIIHYAFLPSGPDRHFFIMNQSNGTISSAVSFDYEERRIYTLQIKAKNPDSSMESYANLYVHVLGVNEFYPQFLQPVFHFDVSETSAVGTRVGAVQATDKDSGEDGRVYYLLVGSSNDKGFRIDTNTGLIYVARHLDRETQNRVVLTVMAKNYGSIRGNDTDEAQVIISIQDGNDPPEFIKHYYTSTISEAAPVGTKVTTVKAIDKDVRTQNNQFSYSIINGNLKQSFKIDVQTGEISTASRLDREETSTYNLVIGAIDTGLPPQTGSATVHIELEDVNDNGPTFTPEGLNGYISENEPAGTSIMTLIASDPDLPRNGGPFTYQLIGGKHKSWLSVDRNSGVVRSTTSFDREMTPILEAIIEVEDSGKPKQKSQHLLTITVLDQNDNPSTTRSLHIAVSLFNGDLPSNVKLADVRPNDIDIVGDYRCRLQKNPAQSQLQLAIPRACDLITTSHTTPIASVFSYTGNDGKHGDVSSKVSVAFQSFNNETLANSVSIMVRNMTAYHFLANHYRPILEMIKSRMSNEDEVILYSLLEGGSGNSTNLQLLMAVRLAKTSYQQPKYLIERLREKRSAFSELLQKEVIVGYEPCSEPDVCENGGVCSATMRLLDAHSFVIQDSPALVLSGPRVVHDYSCQCTSGFSGEQCSRRQDPCLPNPCHSQVQCRRLGSDFQCMCPANRDGKHCEKERSDVCYSKPCRNGGSCQRSPDGSSYFCLCRPGFRGNQCESVSDSCRPNPCLHGGLCVSLKPGYKCNCTPGRYGRHCERFSYGFQPLSYMTFPALDVTTNDISIVFATTKPNSLLLYNYGMQSGGRSDFLAIELVHGRAYFSSGGARTAISTVIAGRNLADGGWHKVTATRNGRVMSLSVAKCADSGDVCTECLPGDSSCYADEVGPVGTLNFNKQPLMIGGLSSADPILERPGQVHSDDLVGCLHSVHIGGRALNLSLPLQQKGILAGCNRQACQPALAAERCGGFAGQCIDRWSSSLCQCGGHLQSPDCSDSLEPITLGEGAFVEFRISEIYRRMQLLDNLYNSKSAWLDNQQMRERRAVSNFSTASQIYEAPKMLSMLFRTYKDQGQILYAATNQMFTSLSLREGRLVYYSKQHLTINMTVQETSTLNDGKWHNVSLFSESRSLRLIVDGRQVGDELDIAGVHDFLDPYLTILNVGGEAFVGCLANVTVNNELQPLNGSGSIFPEVRYHGKIESGCRGDIGQDAAQVADPLSIGFTLVIVFFVILVVAILGSYVIYRFRGKQEKIGSLSCGVPGFKIKHPGGPVTQSQVDHVLVRNLHPSEAPSPPVGAGDHMRPPVGSHHLVGPELLTKKFKEPTAEMPQPQQQQQRPQRPDIIERESPLIREDHHLPIPPLHPLPLEHASSVDMGSEYPEHYDLENASSIAPSDIDIVYHYKGYREAAGLRKYKASVPPVSAYTHHKHQNSGSQQQQQQHRHTAPFVTRNQGGQPPPPPTSASRTHQSTPLARLSPSSELSSQQPRILTLHDISGKPLQSALLATTSSSGGVGKDVHSNSERSLNSPVMSQLSGQSSSASRQKPGVPQQQAQQTSMGLTAEEIERLNGRPRTCSLISTLDAVSSSSEAPRVSSSALHMSLGGDVDAHSSTSTDESGNDSFTCSEIEYDNNSLSGDGKYSTSKSLLDGRSPVSRALSGGETSRNPPTTVVKTPPIPPHAYDGFESSFRGSLSTLVASDDDIANHLSGIYRKANGAASPSATTLGWEYLLNWGPSYENLMGVFKDIAELPDTNGPSQQQQQQTQVVSTLRMPSSNGPAAPEEYV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
239N-linked_GlycosylationSRGSYQLNISARDGG
CCCEEEEEEEECCCC		15.62-
257N-linked_GlycosylationRFGYLQVNVTILDVN
CCEEEEEEEEEEECC		16.56-
276N-linked_GlycosylationIFDHSDYNVSLNETA
CCCCCCCEEECCCCC		23.15-
280N-linked_GlycosylationSDYNVSLNETALPGT
CCCEEECCCCCCCCC		36.75-
402N-linked_GlycosylationTVDENAVNGTVVAAV
EEECCCCCCEEEEEE		37.70-
461N-linked_GlycosylationREEIGKYNLTVVAMD
HHHHHCCEEEEEEEC		32.49-
605N-linked_GlycosylationQFSQREQNVTLGEDA
CCCHHHCCCCCCCCC		24.80-
631N-linked_GlycosylationTDHDQGTNGSVTFAL
CCCCCCCCCEEEEEE		47.79-
1155N-linked_GlycosylationDNAPQFTNSTFTFSI
CCCCCCCCCEEEEEC		40.10-
1367N-linked_GlycosylationLKHPLSSNASITIVV
HCCCCCCCCEEEEEE		34.04-
1458N-linked_GlycosylationDITSYTLNITASDCG
HCCEEEEEEEHHHCC		23.05-
1645PhosphorylationLVTYEIVSGPQELFK
EEEEEEEECHHHHHH		50.8722817900
1751N-linked_GlycosylationEIEYFVTNVTATGSR
EEEEEEEEEEECCCC		24.68-
1831N-linked_GlycosylationLDTPFVYNVSEDLQI
CCCCCEEEECCCCCC		26.07-
1880N-linked_GlycosylationSTGKLILNDTLDRET
CCCCEEECCCCCCCC		32.97-
2080N-linked_GlycosylationSEFGIDSNGTIRTRR
CCCCCCCCCEEEECC		48.13-
2171N-linked_GlycosylationVPVFISANETAIMEN
CCEEEECCCCCCCCC		40.12-
2247N-linked_GlycosylationLRSSYLLNITARDRG
HHHHHEECEEECCCC		27.28-
2290N-linked_GlycosylationYSASVAENASIGAMV
CCCHHHCCCCCCEEE		29.29-
2437N-linked_GlycosylationDSDLFRINASSGDIA
CCCCEEEECCCCCEE		29.52-
2581N-linked_GlycosylationEPRASSVNLTISVSD
CCCCCEEEEEEEEEC		33.15-
2799N-linked_GlycosylationSVTLITLNVTDANDN
EEEEEEEECCCCCCC		26.45-
2920N-linked_GlycosylationFTRLFSLNVTENAEI
EEEEEEEEECCCCEE		37.15-
2946N-linked_GlycosylationLDLGANANASYSFSE
CCCCCCCCCCEECCC		29.26-
2967N-linked_GlycosylationRIEPQSGNITVAGHL
EECCCCCCEEEEEEC		31.82-
3167N-linked_GlycosylationDYSLMTFNLSSIFSV
CEEEEEEEHHHCEEC		29.82-
3303N-linked_GlycosylationLIQEYHLNITVQDLG
HHHHHCCCEEHHHCC		17.99-
3386N-linked_GlycosylationDRHFFIMNQSNGTIS
CCEEEEEECCCCEEE		36.99-
3389N-linked_GlycosylationFFIMNQSNGTISSAV
EEEEECCCCEEEECE		41.69-
3525N-linked_GlycosylationNYGSIRGNDTDEAQV
CCCCCCCCCCCCCEE		38.88-
3852N-linked_GlycosylationVAFQSFNNETLANSV
EEEECCCCCHHHHHH		41.44-
3865N-linked_GlycosylationSVSIMVRNMTAYHFL
HHHEHHCCHHHHHHH		22.27-
3905N-linked_GlycosylationLLEGGSGNSTNLQLL
HHCCCCCCCHHHHHH		47.56-
4306N-linked_GlycosylationHIGGRALNLSLPLQQ
EECCCEEECCCCHHH		26.97-
4414N-linked_GlycosylationRERRAVSNFSTASQI
HHHHHHCCCCCHHHH		28.43-
4471N-linked_GlycosylationSKQHLTINMTVQETS
ECCCEEEEEEEEEEE		18.16-
4487N-linked_GlycosylationLNDGKWHNVSLFSES
CCCCCEEEEEEEECC		24.77-
4539N-linked_GlycosylationAFVGCLANVTVNNEL
EEEEEEEEEEECCCE		19.62-
4550N-linked_GlycosylationNNELQPLNGSGSIFP
CCCEECCCCCCCCCC		49.63-
4786PhosphorylationKASVPPVSAYTHHKH
CCCCCCCHHHCCCCC		22.7222817900
4788PhosphorylationSVPPVSAYTHHKHQN
CCCCCHHHCCCCCCC		10.0922817900
4789PhosphorylationVPPVSAYTHHKHQNS
CCCCHHHCCCCCCCC		19.7422817900
4840PhosphorylationSTPLARLSPSSELSS
CCCCCCCCCCHHHHC		19.7222817900
4843PhosphorylationLARLSPSSELSSQQP
CCCCCCCHHHHCCCC		46.0418327897
4938S-palmitoylationLNGRPRTCSLISTLD
HCCCCCCCHHHHHHH		3.0828031421
4987S-palmitoylationSGNDSFTCSEIEYDN
CCCCCEEEEEEEECC		3.0228031421
5014PhosphorylationKSLLDGRSPVSRALS
HHHHCCCCCCHHHHC		34.8722817900
5054PhosphorylationFESSFRGSLSTLVAS
CCCCCCCCHHHEEEC		18.1922817900
5061PhosphorylationSLSTLVASDDDIANH
CHHHEEECCHHHHHH		33.8125107277
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FAT_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FAT_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FAT_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KRAF1_DROMEphlgenetic
15652705
MYC_DROMEdmgenetic
20885789
AJUBA_DROMEjubgenetic
21666802
EXPA_DROMEexgenetic
16996266
EXPA_DROMEexgenetic
16996265
DS_DROMEdsgenetic
16687445
DS_DROMEdsgenetic
20826534
DS_DROMEdsgenetic
11893338
DS_DROMEdsgenetic
22399682
WNTG_DROMEwggenetic
15342474
PDM1_DROMEnubgenetic
10842062
VG_DROMEvggenetic
7781886
FOJO_DROMEfjgenetic
14757640
FOJO_DROMEfjgenetic
15240556
YAP1_DROMEykigenetic
16996265
YAP1_DROMEykigenetic
21278706
RHOM_DROMErhogenetic
15652705
WARTS_DROMEwtsgenetic
16996265
WARTS_DROMEwtsgenetic
19574458
WARTS_DROMEwtsgenetic
23318637
AP2A_DROMEAP-2alphaphysical
24114784
DS_DROMEdsphysical
20434337
HRS_DROMEHrsphysical
24114784
FAT_DROMEftphysical
19540118
RAGP1_DROMERanGAPphysical
24114784
INO1_DROMEInosphysical
24114784
PNUT_DROMEpnutphysical
24114784
TERA_DROMETER94physical
24114784
RIR2_DROMERnrSphysical
24114784
ENA_DROMEenaphysical
24114784
41_DROMEcoraphysical
24114784
CDV3_DROMECG3760physical
24114784
Y1505_DROMECG11505physical
24114784
LASP1_DROMELaspphysical
24114784
HEM_DROMEHemphysical
24114784
YC17_DROMECG16817physical
24114784
SUV39_DROMESu(var)3-9physical
24114784
SEPT2_DROMESep2physical
24114784
MOB1_DROMEmatsphysical
24114784
ALF_DROMEAldphysical
24114784
DCO_DROMEdcophysical
19540118
DCO_DROMEdcophysical
19574458
DCO_DROMEdcophysical
23318637
DYN_DROMEshiphysical
24114784
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FAT_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4843; SER-5054 ANDSER-5061, AND MASS SPECTROMETRY.

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